{"id":4898,"date":"2021-07-18T08:47:33","date_gmt":"2021-07-17T23:47:33","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4898"},"modified":"2021-07-18T15:32:47","modified_gmt":"2021-07-18T06:32:47","slug":"ace2-igg4-fc%e8%9e%8d%e5%90%88%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%82%92%e9%87%a3%e3%82%8a%e9%a4%8c%e3%81%a8%e3%81%97%e3%81%a6%e9%bc%bb%e8%85%94%e3%81%ab%e7%99%ba%e7%8f%be%e3%81%95","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/ace2-igg4-fc%e8%9e%8d%e5%90%88%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%82%92%e9%87%a3%e3%82%8a%e9%a4%8c%e3%81%a8%e3%81%97%e3%81%a6%e9%bc%bb%e8%85%94%e3%81%ab%e7%99%ba%e7%8f%be%e3%81%95\/","title":{"rendered":"ACE2-IgG4 Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u91e3\u308a\u990c\u3068\u3057\u3066\u9f3b\u8154\u306b\u767a\u73fe\u3055\u305b\u308bAAV\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u305fSARS-CoV-2\u306e\u611f\u67d3\u963b\u5bb3\u907a\u4f1d\u5b50\u6cbb\u7642"},"content":{"rendered":"

University of Pennsylvania, Philadelphia, USA\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u3092\u611f\u67d3\u963b\u5bb3\u3059\u308b\u70ba\u306b\u3001AAV\u30d9\u30af\u30bf\u30fc\u306b\u4e57\u305b\u305fACE2-IgG4 Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u91e3\u308a\u990c\u3068\u3057\u3066\u9f3b\u8154\u5185\u306b\u30b9\u30d7\u30ec\u30fc\u3059\u308b\u3068\u3044\u3046\u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u63d0\u6848\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1009544<\/a><\/p>\n

SARS-CoV-2\u306e\u5e45\u5e83\u3044\u5909\u7570\u306b\u5bfe\u3057\u30661,000\u500d\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u6539\u5584\u3057\u305fACE2\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u958b\u767a\u3057\u3001\u305d\u308c\u3092IgG4 Fc\u3068\u878d\u5408\u3059\u308b\u3053\u3068\u3067SARS-CoV-2\u306b\u5bfe\u3059\u308b\u91e3\u308a\u990c\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u307e\u3057\u305f\u3002\u6700\u3082\u512a\u308c\u305fSARS-CoV-2\u306b\u5bfe\u3059\u308b\u91e3\u308a\u990c\u3068\u306a\u308b\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092 CDY14-Fc \u3068\u540d\u4ed8\u3051\u307e\u3057\u305f\u3002\u3053\u306e\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\uff65\u30de\u30c1\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u9175\u6bcd\u30c7\u30a3\u30b9\u30d7\u30ec\u30a4\u306b\u3088\u308b (>108<\/sup>\u306b\u3082\u4e0a\u308b) ACE2 \u5909\u7570\u4f53\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\u3092\u7528\u3044\u3066\u5b9f\u73fe\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

CDY14-Fc \u304cSARS-CoV-2\u306e\u5404\u7a2e\u5909\u7570\u682a\uff08B.1.1.7\/\u30a2\u30eb\u30d5\u30a1\u30fc\u5909\u7570\u682a\u3001417N\/484K\/501Y from B1.351\/\u30d9\u30fc\u30bf\u5909\u7570\u682a\u3001452R\/484Q from B.1.617.1\/\u30ab\u30c3\u30d1\u30fc\u5909\u7570\u682a\u306a\u3069\u306a\u3069\uff09\u3092\u4e2d\u548c\u3067\u304d\u308b\u3053\u3068\u304c\u4e0b\u56f3\u306e\u3088\u3046\u306b\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u6297\u4f53\u3068\u306f\u7570\u306a\u308a\u3001\u91e3\u308a\u990c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u65b9\u304c\u3088\u308a\u5e83\u3044\u4e2d\u548c\u6d3b\u6027\u3092\u793a\u3057\u3001\u5909\u7570\u682a\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u3053\u306e\u65b9\u6cd5\u306e\u30b4\u30fc\u30eb\u306f\u3001\u91e3\u308a\u990c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u3057\u305fAAV\u30d9\u30af\u30bf\u30fc\u3092\u30b9\u30d7\u30ec\u30fc\u3067\u9f3b\u8154\u5185\u306b\u5674\u9727\u3057\u3001\u9f3b\u8154\u5185\u3067\u91e3\u308a\u990c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3055\u305b\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u30a2\u30a4\u30c7\u30a2\u306e\u6709\u52b9\u6027\u306f\u3001\u985e\u4eba\u733f\u3092\u7528\u3044\u305fin vivo\u5b9f\u9a13\u306b\u3066\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

University of Pennsylvania, Philadelphia, USA\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u3092\u611f\u67d3\u963b\u5bb3\u3059\u308b\u70ba\u306b\u3001AAV\u30d9\u30af\u30bf\u30fc\u306b\u4e57\u305b\u305fACE2-IgG4 Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u91e3\u308a\u990c\u3068\u3057\u3066\u9f3b\u8154\u5185<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-4898","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4898"}],"version-history":[{"count":25,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4898\/revisions"}],"predecessor-version":[{"id":4935,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4898\/revisions\/4935"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}