{"id":4877,"date":"2021-07-17T05:54:24","date_gmt":"2021-07-16T20:54:24","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4877"},"modified":"2022-05-11T15:45:05","modified_gmt":"2022-05-11T06:45:05","slug":"sars-cov-2%e3%81%aeoligo-mannose%e3%81%a8s2%e3%81%aehr1%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3%e3%82%92%e4%b8%a1%e7%9d%a8%e3%81%bf%e3%81%99%e3%82%8b%e4%ba%8c%e4%be%a1%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%aeoligo-mannose%e3%81%a8s2%e3%81%aehr1%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3%e3%82%92%e4%b8%a1%e7%9d%a8%e3%81%bf%e3%81%99%e3%82%8b%e4%ba%8c%e4%be%a1%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af\/","title":{"rendered":"SARS-CoV-2\u306eoligo-mannose\u3068S2\u306eHR1\u30c9\u30e1\u30a4\u30f3\u3092\u4e21\u7768\u307f\u3059\u308b\u4e8c\u4fa1\u30bf\u30f3\u30d1\u30af\u8cea\u3067SARS-CoV-2\u306e\u611f\u67d3\u3092\u6291\u3048\u308b"},"content":{"rendered":"<p>Hanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u611f\u67d3\u3092\u6291\u3048\u308b\u70ba\u306b\u3001SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306eoligo mannose\u3068S2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306b\u3042\u308bHR1\u30c9\u30e1\u30a4\u30f3\u3092\u4e21\u7768\u307f\u3059\u308b\u4e8c\u4fa1\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8264481\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8264481\/<\/a><\/p>\n<p>\u5bbf\u4e3b\u7d30\u80de\u306b\u611f\u67d3\u3059\u308b\u70ba\u306b\u3001 SARS-CoV-2 \u306fSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306eS1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306b\u5b58\u5728\u3059\u308bRBD\u3092\u4ecb\u3057\u3066\u5bbf\u4e3b\u7d30\u80de\u8868\u9762\u306eACE2\u3068\u7d50\u5408\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306b\u3088\u308b\u5207\u65ad\u3092\u53d7\u3051\u3066\u3001Spike\u306eS2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u69cb\u9020\u5909\u5316\u304c\u8d77\u3053\u308a\u3001HR1 \u3068 HR2\u30c9\u30e1\u30a4\u30f3\u306e\u9593\u306bsix-helix bundle\uff086-HB\uff09\u304c\u5f62\u6210\u3055\u308c\u3001\u819c\u878d\u5408\u306b\u5411\u3051\u3066\u30a6\u30a4\u30eb\u30b9\u3068\u5bbf\u4e3b\u7d30\u80de\u3092\u6a4b\u6e21\u3057\u3057\u307e\u3059\u3002\u305d\u308c\u6545\u3001SARS-CoV-2\u306e\u819c\u878d\u5408\u3068\u4fb5\u5165\u3092\u963b\u5bb3\u3059\u308b\u70ba\u306b\u306f\u3001S1\u3001S2\u4e21\u65b9\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u304c\u91cd\u8981\u306a\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308a\u5f97\u307e\u3059\u3002S2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u69cb\u9020\u306f\u3001S1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3088\u308a\u3082\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u70ba\u3001\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u611f\u67d3\u963b\u5bb3\u306b\u5bfe\u3057\u3066\u306f\u3001\u3088\u308a\u9069\u5fdc\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u8457\u8005\u3089\u306f\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3059\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308bGRFT\uff08oligo mannose\u306b\u7d50\u5408\u7279\u7570\u6027\u3092\u6709\u3059\u308b\uff09\u3068\u3001HR1\u30c9\u30e1\u30a4\u30f3\u306b\u5bfe\u3059\u308b\u963b\u5bb3\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308bEK1\u3092\u542b\u3080\u4e8c\u4fa1\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308a\u4e0a\u3052\u3001SARS-CoV-2\u306e\u5909\u7570\u682a\u3084\u305d\u306e\u4ed6\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3078\u306e\u963b\u5bb3\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u30023\u7a2e\u306e\u4e8c\u4fa1\u30bf\u30f3\u30d1\u30af\u8cea\uff08GRFT \u3068 EK1\u3092\u542b\u3080\uff09\u30d7\u30e9\u30b9\u30df\u30c9\u3092\u4f5c\u308a\u4e0a\u3052\u3001\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5f97\u307e\u3057\u305f\u30023\u7a2e\u306e\u305d\u308c\u306f\u3001GRFT\u3068EK1\u306e\u9593\u306e\u30ea\u30f3\u30ab\u30fc\u69cb\u9020\u304c\u305d\u306e\u9577\u3055\u3068\u3044\u3046\u70b9\u3067\u7570\u306a\u3063\u3066\u304a\u308a\u3001\u5177\u4f53\u7684\u306b\u306f\u6b21\u306e\u3088\u3046\u306a3\u7a2e\u306e\u30ea\u30f3\u30ab\u30fc\u3001L15 (GGGGS)<sub>3<\/sub>\u3001L25 (GGGGS)<sub>5<\/sub>\u3001(GGGGS)<sub>7<\/sub> \u3092\u4f7f\u3063\u3066\u3044\u307e\u3059\u3002\u51fa\u6765\u4e0a\u304c\u3063\u305f3\u7a2e\u306e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u306f\u3001\u6b21\u306e\u3088\u3046\u306b\u547d\u540d\u3055\u308c\u307e\u3057\u305f\u3001GRFT-L15-EK1 (GL15E)\u3001GRFT-L25-EK1 (GL25E)\u3001GRFT-L35-EK1 (GL35E)\u3002<\/p>\n<p>\u8a55\u4fa1\u306e\u7d50\u679c\u3001GL25E \u6700\u3082\u512a\u308c\u305f\u963b\u5bb3\u52b9\u679c\u3092\u6301\u3064\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u4e0b\u56f3\u53c2\u7167\uff09\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GRFTEK1_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4881\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GRFTEK1_SARS-CoV-2-300x155.png\" alt=\"\" width=\"300\" height=\"155\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GRFTEK1_SARS-CoV-2-300x155.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GRFTEK1_SARS-CoV-2.png 489w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GL25E-is-the-best_SARS-Cov-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4883\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GL25E-is-the-best_SARS-Cov-2-300x294.png\" alt=\"\" width=\"300\" height=\"294\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GL25E-is-the-best_SARS-Cov-2-300x294.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GL25E-is-the-best_SARS-Cov-2-600x588.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/GL25E-is-the-best_SARS-Cov-2.png 686w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u611f<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%aeoligo-mannose%e3%81%a8s2%e3%81%aehr1%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3%e3%82%92%e4%b8%a1%e7%9d%a8%e3%81%bf%e3%81%99%e3%82%8b%e4%ba%8c%e4%be%a1%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-4877","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4877"}],"version-history":[{"count":11,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4877\/revisions"}],"predecessor-version":[{"id":8770,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4877\/revisions\/8770"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4877"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4877"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}