{"id":4846,"date":"2021-07-16T07:44:56","date_gmt":"2021-07-15T22:44:56","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4846"},"modified":"2021-07-21T22:50:39","modified_gmt":"2021-07-21T13:50:39","slug":"niclosamide%e3%81%aesars-cov-2%e6%84%9f%e6%9f%93%e9%98%bb%e5%ae%b3%ef%bc%9asars-cov-2%e3%81%ae%e3%82%a8%e3%83%b3%e3%83%89%e3%82%b5%e3%82%a4%e3%83%88%e3%83%bc%e3%82%b7%e3%82%b9%e3%82%92%e5%88%a9","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/niclosamide%e3%81%aesars-cov-2%e6%84%9f%e6%9f%93%e9%98%bb%e5%ae%b3%ef%bc%9asars-cov-2%e3%81%ae%e3%82%a8%e3%83%b3%e3%83%89%e3%82%b5%e3%82%a4%e3%83%88%e3%83%bc%e3%82%b7%e3%82%b9%e3%82%92%e5%88%a9\/","title":{"rendered":"Niclosamide\u306eSARS-CoV-2\u611f\u67d3\u963b\u5bb3\uff1aSARS-CoV-2\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3092\u5229\u7528\u3057\u305f\u611f\u67d3\u7d4c\u8def\u306e\u963b\u5bb3"},"content":{"rendered":"

National Centre for Biological Sciences (TIFR), Bengaluru, India\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2 \u611f\u67d3\u306b\u304a\u3051\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3092\u5229\u7528\u3057\u305f\u611f\u67d3\u7d4c\u8def\u306e\u91cd\u8981\u6027\u306b\u3064\u3044\u3066\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1009706<\/a><\/p>\n

\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306b\u304a\u3051\u308b\u30ad\u30fc\u3068\u306a\u308b\u30b9\u30c6\u30c3\u30d7\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u907a\u4f1d\u5b50\u306e\u5bbf\u4e3b\u7d30\u80de\u306e\u7d30\u80de\u8cea\u5185\u3078\u306e\u653e\u51fa\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3092\u884c\u3046\u305f\u3081\u306b\u3001\u30a6\u30a4\u30eb\u30b9\u306f\u7d30\u80de\u819c\u4e0a\u306e\u7279\u5b9a\u306e\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u3001\u5f15\u304d\u7d9a\u3044\u3066\u76f4\u63a5\u7684\u306b\u7d30\u80de\u819c\u3068\u878d\u5408\u3001\u3042\u308b\u3044\u306f\u307e\u305f\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u308b\u53d6\u308a\u8fbc\u307f\u306b\u5f15\u304d\u7d9a\u3044\u3066\u7d30\u80de\u819c\u878d\u5408\u3092\u884c\u3044\u307e\u3059\u3002\u3053\u306e\u4e21\u65b9\u306e\u7d30\u80de\u611f\u67d3\u30eb\u30fc\u30c8\u306f\u3001SARS-CoV-2 \u306e\u611f\u67d3\u306b\u304a\u3044\u3066\u8d77\u304d\u3066\u3044\u308b\u3088\u3046\u3067\u3042\u308a\u3001\u5bbf\u4e3b\u7d30\u80de\u819c\u4e0a\u306e\u53d7\u5bb9\u4f53\u3084\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306e\u53ef\u7528\u6027\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002Angiotensin converting enzyme 2 (ACE2) \u304cSARS-CoV-2\u306e\u826f\u304f\u77e5\u3089\u308c\u305f\u53d7\u5bb9\u4f53\u3067\u3042\u308a\u307e\u3059\u304c\u3001\u4ed6\u306e\u53d7\u5bb9\u4f53\uff08C-\u578b\u30ec\u30af\u30c1\u30f3\u306a\u3069\uff09\u3084\u5171\u53d7\u5bb9\u4f53\uff08\u30d8\u30d1\u30e9\u30f3\u786b\u9178\u306a\u3069\uff09\u304c\u6570\u591a\u304f\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u52a0\u3048\u3066\u3001SARS-CoV-2 \u306f\u3001\u4fb5\u5165\u3092\u679c\u305f\u3059\u306b\u306f\u3001\u5bbf\u4e3b\u7d30\u80de\u306e\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306b\u3088\u308b\u30a6\u30a4\u30eb\u30b9\u306eSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5207\u65ad\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002\u305d\u308c\u6545\u3001\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u3082\u3057\u3082Spike\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7d30\u80de\u819c\u4e0a\u306eTMPRSS2\u306e\u3088\u3046\u306a\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306b\u3088\u3063\u3066\u5207\u65ad\u3055\u308c\u308b\u5834\u5408\u306b\u306f\u3001\u7d30\u80de\u819c\u4e0a\u3067\u76f4\u63a5\u7684\u306b\u878d\u5408\u3057\u3001\u305d\u3046\u3067\u306a\u3044\u5834\u5408\u306b\u306f\u3001\u30a8\u30f3\u30c9\u30fc\u30e9\u30a4\u30bd\u30bd\u30fc\u30e0\u7d4c\u8def\u3092\u7d30\u80de\u819c\u878d\u5408\u306b\u4f7f\u7528\u3057\u3001\u305d\u3053\u3067\u306fSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u30b7\u30b9\u30c6\u30a4\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3067\u3042\u308b cathepsin\u306b\u3088\u3063\u3066Spike\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30d7\u30e9\u30a4\u30e0\u72b6\u614b\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u3001\u5bbf\u4e3b\u7d30\u80de\u306b\u304a\u3051\u308b\u30a6\u30a4\u30eb\u30b9\u306e\u4fb5\u5165\u3068\u611f\u67d3\u306f\u3001\u3053\u308c\u3089\u306e\u30ad\u30fc\u3068\u306a\u308b\u8981\u7d20\u3001\u3059\u306a\u308f\u3061\u53d7\u5bb9\u4f53\uff08ACE2\u306a\u3069\uff09\u3084\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08furin, TMPRSS2, cathepsin\uff09\u306e\u5b58\u5728\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5f71\u97ff\u3055\u308c\u307e\u3059\u3002<\/p>\n

CLIC\/GEEC (CG) \u7d4c\u8def\u306f\u3001clathrin-\u975e\u4f9d\u5b58\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\uff08CLIC\uff53\uff09\u3067\u3042\u308b\u7d30\u7ba1\u5c0f\u80de\u8f38\u9001\uff08tubulovesicular primary carriers\uff09\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u307e\u3059\u3002\u7d30\u7ba1\u5c0f\u80de\u306f\u7d30\u80de\u819c\u304b\u3089\u76f4\u63a5\u7684\u306b\u767a\u751f\u3057\u3001\u305d\u306e\u5f8c\u30b0\u30ea\u30b3\u30b7\u30eb\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\uff08GPI\u30a2\u30f3\u30ab\u30fc\uff09\u6fc3\u7e2e\u5c0f\u80de\uff08GEECs\uff09\u3068\u547c\u3070\u308c\u308b\u7d30\u7ba1\u5c0f\u80de\u3078\u3068\u6210\u719f\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n

\u8457\u8005\u3089\u306f\u3001ACE2\u306e\u767a\u73fe\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u305f\u80c3\u4e0a\u76ae\u7d30\u80de\uff08AGS\uff09\u3092\u7528\u3044\u3066\u3001SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306eRBD\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3092\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002AGS\u306f\u3001\u901a\u5e38\u3067\u306fACE2\u3092\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\u7d30\u80de\u682a\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u3053\u306eAGS\u306b\u304a\u3044\u3066\u306f\u3001RBD\u306f\u3001clathrin-mediated endocytosis (CME) \u7d4c\u8def\u3067\u306f\u306a\u304f\u3001CG \u7d4c\u8def\u306b\u3088\u3063\u3066\u53d6\u308a\u8fbc\u307e\u308c\u3066\u304a\u308a\u3001AGS\u7d30\u80de\u306b\u304a\u3051\u308b\u85ac\u7406\u7684\u306a\u64fe\u4e71\u306b\u654f\u611f\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

AGS\u7d30\u80de\u306b\u304a\u3051\u308bACE2\u306e\u52b9\u679c\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001ACE2\u3092\u7570\u6240\u7684\u306b\u767a\u73fe\u3055\u305b\u305f\u5b89\u5b9a\u682a\uff08AGS-ACE2\uff09\u3092\u4f5c\u308a\u307e\u3057\u305f\uff08ACE2 \u306e\u767a\u73fe\u306f\u3001qPCR\u3068\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff09\u3002\u3053\u306e\u3088\u3046\u306b\u6539\u5909\u3057\u305fAGS-ACE2 \u7d30\u80de\u306b\u304a\u3044\u3066\u306f\u3001RBD\u306e\u53d6\u308a\u8fbc\u307f\u306f\u3001AGS\u7d30\u80de\u306b\u6bd4\u3079\u30663\u500d\u307b\u3069\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002AGS-ACE2\u7d30\u80de\u306b\u304a\u3051\u308bRBD\u306e\u53d6\u308a\u8fbc\u307f\u7d4c\u8def\u3092\u78ba\u8a8d\u3059\u308b\u4e2d\u306b\u304a\u3044\u3066\u3001RBD\u3068\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30ea\u30f3\u306e\u5897\u52a0\u304c\u540c\u6642\u306b\u8d77\u3053\u3063\u3066\u304a\u308a\u3001AGS\u7d30\u80de\u3068\u6bd4\u8f03\u3057\u3066RBD\u3068dextran\u306e\u540c\u6642\u53d6\u308a\u8fbc\u307f\u304c\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002 \u3053\u306e\u3053\u3068\u306f\u3001CG\u7d4c\u8def\u306b\u52a0\u3048\u3066\u3001AGS-ACE2\u7d30\u80de\u306b\u304a\u3044\u3066\u306f\u3001CME\u7d4c\u8def\u3092\u4ecb\u3057\u305fRBD\u306e\u53d6\u308a\u8fbc\u307f\u304c\u652f\u914d\u7684\u306b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u6700\u5f8c\u306b\u3001niclosamide \u304c\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u5185pH\u3092\u4e2d\u6027\u5316\u3057\u3001SARS-CoV-2\u306e\u611f\u67d3\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u304c\u4e0b\u56f3\u306e\u3088\u3046\u306b\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u3092\u793a\u3059\u3082\u306e\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

National Centre for Biological Sciences (TIFR), Bengaluru, India\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2 \u611f\u67d3\u306b\u304a\u3051\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3092\u5229\u7528\u3057\u305f\u611f\u67d3\u7d4c\u8def\u306e\u91cd\u8981<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-4846","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4846","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4846"}],"version-history":[{"count":16,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4846\/revisions"}],"predecessor-version":[{"id":5043,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4846\/revisions\/5043"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4846"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4846"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}