{"id":4818,"date":"2021-07-13T08:30:42","date_gmt":"2021-07-12T23:30:42","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4818"},"modified":"2021-07-21T22:51:36","modified_gmt":"2021-07-21T13:51:36","slug":"covid-19%e3%82%92%e7%99%ba%e7%97%87%e3%81%99%e3%82%8b%e3%81%a8%e3%82%b9%e3%83%95%e3%82%a3%e3%83%b3%e3%82%b4%e3%82%b7%e3%83%b3%e3%81%8c%e6%b8%9b%e5%b0%91%e3%81%97%e3%81%a6%e3%81%84%e3%82%8b","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/covid-19%e3%82%92%e7%99%ba%e7%97%87%e3%81%99%e3%82%8b%e3%81%a8%e3%82%b9%e3%83%95%e3%82%a3%e3%83%b3%e3%82%b4%e3%82%b7%e3%83%b3%e3%81%8c%e6%b8%9b%e5%b0%91%e3%81%97%e3%81%a6%e3%81%84%e3%82%8b\/","title":{"rendered":"COVID-19\u3092\u767a\u75c7\u3059\u308b\u3068\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u304c\u6e1b\u5c11\u3059\u308b"},"content":{"rendered":"<p>Medical University of South Carolina, Charleston, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u8840\u4e2d\u306e\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306e\u6e1b\u5c11\u304c\u3001COVID-19\u306e\u7121\u75c7\u72b6\u60a3\u8005\u3068\u305d\u3046\u3067\u306a\u3044\u30d2\u30c8\u3092\u65e9\u671f\u306b\u898b\u5206\u3051\u308b\u305f\u3081\u306e\u9ad8\u611f\u5ea6\u3067\u7279\u7570\u7684\u306a\u30de\u30fc\u30ab\u30fc\u306b\u306a\u308a\u5f97\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-93857-7\">https:\/\/www.nature.com\/articles\/s41598-021-93857-7<\/a><\/p>\n<p>\u6297\u4f53\u304c\u967d\u6027 (n\u2009=\u2009134) \u3068\u9670\u6027 (n\u2009=\u2009130)\u306e\u6bd4\u8f03\u306b\u304a\u3044\u3066\u3001\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306e\u30ec\u30d9\u30eb\u304c\u967d\u6027\u8005\u3067\u5c11\u3057\u3067\u3059\u304c\u6709\u610f\u306b\uff08p\u2009&lt;\u20090.05\uff09\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u967d\u6027\u8005\uff1d28.96 vs. \u9670\u6027\u8005\uff1d23.25 pmol\/5\u2009\u00d7\u200910\u22125 L serum\uff09\u3002 \u305d\u3057\u3066\u66f4\u306b\u3001COVID-19 \u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u3001\u8840\u4e2d\u306e\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306e\u30ec\u30d9\u30eb\u304c\u7121\u75c7\u72b6\u8005\u306b\u6bd4\u8f03\u3057\u3066\u300115\u500d\u307b\u3069\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u7121\u75c7\u72b6\u8005\uff1d28.96\u3001COVID-19\u60a3\u8005\uff1d1.88 pmol\/5\u2009\u00d7\u200910\u22125 L serum\uff09\u3002\u4e0b\u56f3\u306b\u304a\u3044\u3066\u306f\u3001Sphingosine (Sph)\u3001dihydro-sphingosine (dhSph)\u3001sphingosine 1-phosphate (Sph-1p)\u3068\u7565\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/sphingosin_COVID-19-1.png\"><img decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/sphingosin_COVID-19-1-300x89.png\" alt=\"\" width=\"400\" class=\"alignleft size-medium wp-image-4822\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/sphingosin_COVID-19-1-300x89.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/sphingosin_COVID-19-1-600x179.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/sphingosin_COVID-19-1-768x229.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/sphingosin_COVID-19-1.png 833w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>ROC\u89e3\u6790\u306e\u7d50\u679c\u306f\u3001\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306e\u95be\u5024\u3092 8.2 pmol\/5\u2009\u00d7\u200910\u22125 L \u3068\u8a2d\u5b9a\u3057\u305f\u5834\u5408\u306b\u3001\u611f\u5ea6 \uff1d 98.47%\uff0895% CI 94.60\u201399.73%\uff09\u3001\u7279\u7570\u5ea6 \uff1d 98.51%\uff0895% CI 94.72\u201399.73%\uff09\u304c\u5f97\u3089\u308c\u3001SARS-CoV-2\u6297\u4f53\u306f\u967d\u6027\u3067\u306f\u3042\u308b\u3082\u306e\u306e\u7121\u75c7\u72b6\u306a\u4eba\u3068COVID-19\u60a3\u8005\u3092\u898b\u5206\u3051\u308b\u306b\u9ad8\u611f\u5ea6\u3067\u7279\u7570\u5ea6\u306e\u9ad8\u3044\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002 \u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u3068dihydro-\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306f\u3001\u91cd\u75c7\u5ea6\u306e\u898b\u5206\u3051\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u751f\u5316\u5b66\u7684\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b lactate dehydrogenase\uff08LDH\uff09\u306e\u30ec\u30d9\u30eb\u304c\u3001COVID-19\u60a3\u8005\u306e\u91cd\u75c7\u8005\u3067\u4e0a\u6607\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u4e8b\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u767a\u898b\u3055\u308c\u305f\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306e\u30ec\u30d9\u30eb\u306e\u6e1b\u5c11\u306f\u91cd\u75c7\u5ea6\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3053\u308c\u3089\u3092\u5408\u308f\u305b\u308b\u3068\u3001\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306e\u30ec\u30d9\u30eb\u304c\u9ad8\u3044\u3068COVID-19\u306e\u75c7\u72b6\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u51fa\u6765\u3001\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306e\u30ec\u30d9\u30eb\u304c\u6e1b\u5c11\u3059\u308b\u3068\u708e\u75c7\u304c\u52a9\u9577\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308b\u3068\u8a00\u3048\u305d\u3046\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Medical University of South Carolina, Charleston, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u8840\u4e2d\u306e\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3\u306e\u6e1b\u5c11\u304c\u3001COVID-19\u306e\u7121\u75c7\u72b6\u60a3\u8005\u3068\u305d\u3046\u3067\u306a\u3044\u30d2\u30c8\u3092\u65e9\u671f\u306b\u898b\u5206\u3051\u308b\u305f\u3081\u306e\u9ad8<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/covid-19%e3%82%92%e7%99%ba%e7%97%87%e3%81%99%e3%82%8b%e3%81%a8%e3%82%b9%e3%83%95%e3%82%a3%e3%83%b3%e3%82%b4%e3%82%b7%e3%83%b3%e3%81%8c%e6%b8%9b%e5%b0%91%e3%81%97%e3%81%a6%e3%81%84%e3%82%8b\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-4818","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Medical University of South Carolina, Charleston, USA\u3089\u306e\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/covid-19%e3%82%92%e7%99%ba%e7%97%87%e3%81%99%e3%82%8b%e3%81%a8%e3%82%b9%e3%83%95%e3%82%a3%e3%83%b3%e3%82%b4%e3%82%b7%e3%83%b3%e3%81%8c%e6%b8%9b%e5%b0%91%e3%81%97%e3%81%a6%e3%81%84%e3%82%8b\/\" \/>\n\t<meta name=\"generator\" 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