{"id":4802,"date":"2021-07-12T18:43:00","date_gmt":"2021-07-12T09:43:00","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4802"},"modified":"2021-07-21T22:52:04","modified_gmt":"2021-07-21T13:52:04","slug":"sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%81%ab%e3%82%88%e3%81%a3%e3%81%a6%e3%83%92%e3%83%88%e6%b0%97%e7%ae%a1%e6%94%af%e4%b8%8a%e7%9a%ae%e7%b4%b0%e8%83%9e%e3%81%aeace2%e3%81%ae%e7%99%ba%e7%8f%be","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%81%ab%e3%82%88%e3%81%a3%e3%81%a6%e3%83%92%e3%83%88%e6%b0%97%e7%ae%a1%e6%94%af%e4%b8%8a%e7%9a%ae%e7%b4%b0%e8%83%9e%e3%81%aeace2%e3%81%ae%e7%99%ba%e7%8f%be\/","title":{"rendered":"SARS-CoV-2\u306e\u611f\u67d3\u306b\u3088\u3063\u3066\u30d2\u30c8\u6c17\u7ba1\u652f\u4e0a\u76ae\u7d30\u80de\u306eACE2\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3057\u611f\u67d3\u3092\u52a0\u901f\u3059\u308b"},"content":{"rendered":"<p>Second Military Medical University, Shanghai, China\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8\u306e\u6c17\u7ba1\u652f\u4e0a\u76ae\u7d30\u80de\u3067\u3001SARS-CoV-2\u611f\u67d3\u304cACE2\u306e\u767a\u73fe\u3092\u30a8\u30f3\u30cf\u30f3\u30b9\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8254647\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8254647\/<\/a><\/p>\n<p>SARS-CoV-2\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u3067\u3042\u308bACE2\u304c\u3001\u30d2\u30c8\u306e\u6c17\u7ba1\u652f\u4e0a\u76ae\u7d30\u80de\uff08BASE-2B\u7d30\u80de\uff09\u306bSARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30c8\u3059\u308b\u3053\u3068\u3067\u3001\u5927\u304d\u304f\u767a\u73fe\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u898b\u3064\u304b\u308a\u307e\u3057\u305f\u3002\u4e0b\u56f3\u306b\u304a\u3044\u3066\u3001BASE-2B\u7d30\u80de\u306f\u3001\u7a7a\u306e\u30d9\u30af\u30bf\u30fc\u6216\u3044\u306fSARS-CoV-2 Spike\u3092\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u3057\u305f\u30d9\u30af\u30bf\u30fc\u3067\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30c8\u3055\u308c\u3066\u304a\u308a\u3001long ACE2\u3001dACE2\u3001total ACE2\u3092qRT-PCR\u3067\u691c\u51fa\u3057\u305f\u3068\u3053\u308d\u3001SARS-CoV-2 Spike\u6709\u3067\u5927\u304d\u304f\u767a\u73fe\u4e0a\u6607\u3057\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u307e\u305f\u3001long ACE2 \u3068 dACE2 \u3092\u3001C-terminal anti-ACE2 \u6297\u4f53\u3067Western blot\u3057\u305f\u3082\u306e\u3082\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u540c\u69d8\u306bSARS-CoV-2 Spike\u6709\u3067\u767a\u73fe\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\uff08\u03b2-actin \u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\uff09\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/ACE2-upregulation-by-SARS-CoV-2-Spike.png\"><img decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/ACE2-upregulation-by-SARS-CoV-2-Spike-300x111.png\" alt=\"\" width=\"400\" class=\"alignleft size-medium wp-image-4803\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/ACE2-upregulation-by-SARS-CoV-2-Spike-300x111.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/ACE2-upregulation-by-SARS-CoV-2-Spike-600x222.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/ACE2-upregulation-by-SARS-CoV-2-Spike-1024x378.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/ACE2-upregulation-by-SARS-CoV-2-Spike-768x284.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/ACE2-upregulation-by-SARS-CoV-2-Spike.png 1105w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001IFN-stimulated genes (ISGs)\u306e\u767a\u73fe\u3092\u4fc3\u3057\u307e\u3059\u306e\u3067\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u304cJAK-STAT\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066ACE2\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3067\u304d\u308b\u306e\u304b\u3069\u3046\u304b\uff1f\u3092\u78ba\u8a8d\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u3001Spike\u3092\u904e\u5270\u306b\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u3057\u305fBASE-2B\u7d30\u80de\u3092\u7528\u3044\u3066\u3001\u30ea\u30f3\u9178\u5316\u3068\u3001STAT1 \u3068 STAT2 \u6d3b\u6027\u5316\u3092\u8a55\u4fa1\u3057\u305f\u3068\u3053\u308d\u3001\u78ba\u304b\u306bSARS-CoV-2 Spike\u306e\u5f71\u97ff\u3067\u3001STAT1\u3068STAT2\u306e\u30ea\u30f3\u9178\u5316\u304c\u52a0\u901f\u3055\u308c\u3001\u3053\u308c\u3089\u304c\u6d3b\u6027\u5316\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u66f4\u306b\u3001STAT1\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308bFludarabine \u3092\u52a0\u3048\u305f\u3068\u3053\u308d\u3001BEAS-2B\u7d30\u80de\u306b\u304a\u3051\u308bSARS-CoV-2 Spike\u306b\u3088\u3063\u3066\u8a98\u8d77\u3055\u308c\u305fACE2\u306e\u767a\u73fe\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001SARS-CoV-2 Spike\u304cIFN\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u3067\u3042\u308bJAK-STAT\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066long ACE2\u306e\u767a\u73fe\u3092\u8a98\u8d77\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u660e\u3089\u304b\u3067\u3042\u308a\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Second Military Medical University, Shanghai, China\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8\u306e\u6c17\u7ba1\u652f\u4e0a\u76ae\u7d30\u80de\u3067\u3001SARS-CoV-2\u611f\u67d3\u304cACE2\u306e\u767a\u73fe\u3092\u30a8\u30f3\u30cf\u30f3\u30b9\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%81%ab%e3%82%88%e3%81%a3%e3%81%a6%e3%83%92%e3%83%88%e6%b0%97%e7%ae%a1%e6%94%af%e4%b8%8a%e7%9a%ae%e7%b4%b0%e8%83%9e%e3%81%aeace2%e3%81%ae%e7%99%ba%e7%8f%be\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-4802","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4802"}],"version-history":[{"count":10,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4802\/revisions"}],"predecessor-version":[{"id":5046,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4802\/revisions\/5046"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}