{"id":4793,"date":"2021-07-12T06:00:02","date_gmt":"2021-07-11T21:00:02","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4782"},"modified":"2021-07-11T13:51:14","modified_gmt":"2021-07-11T04:51:14","slug":"epitopes-in-sars-cov-2-s2-can-serve-as-blueprints-for-the-design-of-immunogens-capable-of-eliciting-cross-neutralizing-coronavirus-antibodies","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/epitopes-in-sars-cov-2-s2-can-serve-as-blueprints-for-the-design-of-immunogens-capable-of-eliciting-cross-neutralizing-coronavirus-antibodies\/","title":{"rendered":"Epitopes in SARS-CoV-2 S2 can serve as blueprints for the design of immunogens capable of eliciting cross-neutralizing coronavirus antibodies\u00a0"},"content":{"rendered":"<p>A group from Fred Hutchinson Cancer Research Center, Seattle, USA, etc. has reported that epitopes in SARS-CoV-2 S2 can serve as blueprints for the design of immunogens capable of eliciting cross-neutralizing coronavirus antibodies.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34237283\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34237283\/<\/a><\/p>\n<p>From 198 antibodies isolated from four COVID-19+ convalescent patients, 14 SARS-CoV-2 neutralizing antibodies were isolated. One targeted the N-terminal domain (NTD), one recognized an epitope in S2, and 11 bound the receptor-binding domain (RBD), and those IC<sub>50<\/sub>s ranged from 0.007 \u03bcg\/ml to 15.1 \u03bcg\/ml.<\/p>\n<p>The S2 subunit contains at least one epitope that, although poorly immunogenic, is present on four of five human beta coronaviruses SARS-CoV-1, SARS-CoV-2, OC43, HKU1). That epitope, as defined by its recognition by CV3-25, is a valid candidate for the development of a global coronavirus vaccine. IC<sub>50<\/sub> of C3-25 against SARS-CoV-2 was 0.34 \u03bcg\/ml.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/CV3-25_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/CV3-25_SARS-CoV-2-300x106.png\" alt=\"\" width=\"300\" height=\"106\" class=\"alignleft size-medium wp-image-4786\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/CV3-25_SARS-CoV-2-300x106.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/CV3-25_SARS-CoV-2-600x213.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/CV3-25_SARS-CoV-2.png 765w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Fred Hutchinson Cancer Research Center, Seattle, USA, etc. has reported that epitopes in SARS-CoV<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/epitopes-in-sars-cov-2-s2-can-serve-as-blueprints-for-the-design-of-immunogens-capable-of-eliciting-cross-neutralizing-coronavirus-antibodies\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-4793","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4793"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4793\/revisions"}],"predecessor-version":[{"id":4794,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4793\/revisions\/4794"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}