{"id":4711,"date":"2021-07-09T09:52:42","date_gmt":"2021-07-09T00:52:42","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4711"},"modified":"2021-07-21T22:53:53","modified_gmt":"2021-07-21T13:53:53","slug":"sars-cov-2%e3%81%aefurin-cleavage-site%ef%bc%88prrar%ef%bc%89%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%a4%89%e7%95%b0%e3%81%ae%e5%bd%b1%e9%9f%bf%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%ef%bc%9ap681h","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%aefurin-cleavage-site%ef%bc%88prrar%ef%bc%89%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%a4%89%e7%95%b0%e3%81%ae%e5%bd%b1%e9%9f%bf%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%ef%bc%9ap681h\/","title":{"rendered":"SARS-CoV-2\u306eFurin cleavage site\uff08PRRAR\uff09\u306b\u304a\u3051\u308b\u5909\u7570\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\uff1aP681H\u3068P681R"},"content":{"rendered":"

Cornell University, USA\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306b\u5b58\u5728\u3059\u308bfurin cleavage site\u306eP681R\u5909\u7570\u306e\u5f71\u97ff\u3092\u8b70\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8259907\/<\/a><\/p>\n

\u30a6\u30ac\u30f3\u30c0\u3067\u6d41\u884c\u3057\u305fA.23.1 \u5909\u7570\u682a\u306b\u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u5909\u7570\u304cSARS-CoV-2 Spike\u306b\u5b58\u5728\u3057\u307e\u3059\uff08F157L\u3001V367F\u3001Q613H\u3001R102I\u3001L141F\u3001E484K\u3001P681R\uff09\u3002\u8457\u8005\u3089\u306f\u3001P681R\u306e\u5909\u7570\u306b\u7740\u76ee\u3057\u3001Wild type\uff08P681\uff09\u3068\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\u3001\u4e0b\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\u3001P618R \u5909\u7570\u306f\u3001WT\u306b\u6bd4\u3079\u3066\u3001furin\u306b\u3088\u308bS1\/S2\u306e\u5207\u65ad\u52b9\u7387\u3092\u5927\u5e45\u306b\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4eca\u65e5\u3001\u6700\u3082\u6d41\u884c\u3057\u3066\u3044\u308bSARS-CoV-2\u306e\u5909\u7570\u682a\u306f\u3001B.1.1.7\u3067\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u682a\u306b\u304a\u3044\u3066\u306f\u3001spike S1\/S2 \u201cfurin cleavage site\u201d \u306eP681H\u5909\u7570\u304c\u7279\u5fb4\u3067\u3042\u308a\u3001\u611f\u67d3\u7387\u306e\u4e0a\u6607\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u6975\u6700\u8fd1\u3067\u306f\u3001B.1.617.2 \u3068\u3044\u3046\u65b0\u3057\u3044\u5909\u7570\u682a\u304c B.1.1.7 \u306b\u53d6\u3063\u3066\u4ee3\u308f\u3063\u3066\u6765\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u5909\u7570\u682a\u3082P681R \u5909\u7570\u3092\u3082\u3063\u3066\u304a\u308a\u3001\u540c\u69d8\u306bfurin cleavage site\u306e\u5207\u65ad\u52b9\u7387\u306e\u30a2\u30c3\u30d7\u304c\u611f\u67d3\u62e1\u5927\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n

B.1.617\u5909\u7570\u682a\u4ee5\u524d\u306b\u73fe\u308c\u305fA.23.1 \u5909\u7570\u682a\u306f\u3001\u524d\u8a18\u3057\u305f\u3088\u3046\u306bP681R \u5909\u7570\u3092\u542b\u3093\u3067\u304a\u308a\u30012020\u5e74\u306e10\u6708\u306b\u30a6\u30ac\u30f3\u30c0\u3067\u51fa\u73fe\u3057\u305f\u306e\u3067\u3059\u304c\u30012021\u5e74\u306e5\u6708\u306b\u306f\u6d88\u6ec5\u3057\u3001\u4ed6\u306e\u5909\u7570\u682a B.1.351\u3001B.1.525\uff08P681R\u3092\u6301\u305f\u306a\u3044\uff09\u3084\u3001B.1.617.2\uff08P681R\u3092\u6301\u3064\uff09\u304c\u5e2d\u5dfb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5927\u5c40\u7684\u306b\u898b\u3066\u307f\u308b\u3068\u3001\u3053\u306e\u3053\u3068\u306fP681R \u5909\u7570\u3068\u3044\u3046\u306e\u306f\u3001furin\u3092\u4ecb\u3057\u305fS1\/S2\u5207\u65ad\u306b\u306f\u91cd\u8981\u306a\u306e\u3067\u3059\u304c\u3001\u5fc5\u305a\u3057\u3082\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u529b\u30a2\u30c3\u30d7\u306e\u4e3b\u8981\u306a\u30c9\u30e9\u30a4\u30d0\u30fc\u306b\u306f\u306a\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Cornell University, USA\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306b\u5b58\u5728\u3059\u308bfurin cleavage site\u306eP681R\u5909\u7570\u306e\u5f71\u97ff\u3092\u8b70\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.ncbi.nlm.nih.<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-4711","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4711"}],"version-history":[{"count":11,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4711\/revisions"}],"predecessor-version":[{"id":5050,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4711\/revisions\/5050"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}