{"id":4689,"date":"2021-07-09T07:12:38","date_gmt":"2021-07-08T22:12:38","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4689"},"modified":"2021-07-21T22:54:13","modified_gmt":"2021-07-21T13:54:13","slug":"mannose%e7%89%b9%e7%95%b0%e7%9a%84%e3%81%aa%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6sars-cov-2%e3%82%92%e3%83%96%e3%83%ad%e3%83%83%e3%82%af%e3%81%99%e3%82%8b%ef%bc%9asar","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/mannose%e7%89%b9%e7%95%b0%e7%9a%84%e3%81%aa%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6sars-cov-2%e3%82%92%e3%83%96%e3%83%ad%e3%83%83%e3%82%af%e3%81%99%e3%82%8b%ef%bc%9asar\/","title":{"rendered":"Mannose\u7279\u7570\u7684\u306a\u30ec\u30af\u30c1\u30f3\u3092\u7528\u3044\u3066SARS-CoV-2\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\uff1aSARS-CoV-2\u306b\u306f\u30de\u30e1\u79d1\u30ec\u30af\u30c1\u30f3\u304c\u9069\u3059\u308b"},"content":{"rendered":"

Universit\u00e9 Paul Sabatier, Toulouse, France\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u3001SARS-CoV\u3001MARS-Cov\u306b\u5bfe\u3057\u3066\u6297\u30a6\u30a4\u30eb\u30b9\u52b9\u679c\u3092\u793a\u3059mannose\u7279\u7570\u7684\u306a\u30ec\u30af\u30c1\u30f3\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.mdpi.com\/2073-4409\/10\/7\/1619\/htm<\/a><\/p>\n

\u690d\u7269\u3001\u83cc\u985e\u3001\u85fb\u985e\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306a\u3069\u304b\u3089\u62bd\u51fa\u3055\u308c\u305fMannose\u7279\u7570\u7684\u306a\u30ec\u30af\u30c1\u30f3\u306f\u3001HIV-1\u3001HPV\u3001herpes\u3001HCV\u3001Ebola\u30a6\u30a4\u30eb\u30b9\u3089\u306b\u6297\u30a6\u30a4\u30eb\u30b9\u52b9\u679c\u3092\u793a\u3059\u3068\u3046\u3044\u3046\u89b3\u70b9\u304b\u3089\u591a\u304f\u306e\u7814\u7a76\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u4f8b\u3068\u3057\u3066\u3001\u85fb\u985e\u30ec\u30af\u30c1\u30f3\u306egriffithsin\u3001\u30b7\u30a2\u30ce\u30d0\u30af\u30c6\u30ea\u30a2\u7531\u6765\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308bcyanovirin\u3084microvirin\u3001\u653e\u7dda\u83cc\u7531\u6765\u306eactinohivin\u3001\u5404\u7a2eGNA-\u95a2\u9023\u306e\u30ec\u30af\u30c1\u30f3\uff08NPA \u3084 ASA\u306a\u3069\uff09\u306b\u95a2\u3059\u308b\u8ad6\u6587\u304c\u591a\u304f\u5b58\u5728\u3057\u307e\u3059\u3002\u591a\u304f\u306eMannose\u7279\u7570\u7684\u306a\u30ec\u30af\u30c1\u30f3\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u3092\u3001\u5c11\u306a\u304f\u3068\u3082in vitro\u5b9f\u9a13\u4e0b\u3067\u306f\u3001\u963b\u6b62\u3057\u307e\u3059\u304c\u3001\u30a6\u30a4\u30eb\u30b9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u306b\u5b58\u5728\u3059\u308bMannose\u578b\u306eN-\u578b\u7cd6\u9396\u306b\u5e72\u6e09\u3059\u308b\u80fd\u529b\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

SARS-CoV\u3001MERS-CoV\u3001SARS-CoV-2\u3089\u306eSpike\u3092\u4fee\u98fe\u3059\u308bN-\u578b\u7cd6\u9396\u306f\u3001high-mannose\u306e\u307f\u3067\u306a\u304f\u3001\u3057\u3070\u3057\u3070\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u3092\u4f34\u3046\u8907\u5408\u578b\u304c\u30e1\u30b8\u30e3\u30fc\u3067\u3042\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u6bce\u306b\u3053\u308c\u3089\u7cd6\u9396\u306e\u5206\u5e03\u306b\u306f\u9055\u3044\u304c\u5b58\u5728\u3057\u3066\u304a\u308a\u3001Spike\u306e\u30b7\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306b\u591a\u69d8\u6027\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n

\"\"<\/a>
\n\u56f3\u306e\u8aac\u660e: \u307b\u3068\u3093\u3069\u304c\u8907\u5408\u578b\u3067\u3042\u308b\u5834\u5408 (\u8d64), \u307b\u3068\u3093\u3069\u304chigh-mannose (\u7dd1), \u307b\u3068\u3093\u3069\u304c\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9 (\u30de\u30bc\u30f3\u30bf)\u3002\u3053\u308c\u3089\u306e\u6df7\u5408\u3067\u3042\u3063\u3066\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u304c\u5c11\u306a\u3044\u5834\u5408 (\u30d4\u30f3\u30af)\u3001\u6df7\u5408\u3067high-mannose\u304c\u30e1\u30b8\u30e3\u30fc\u306a\u5834\u5408 (\u8584\u7dd1)\u3001\u6df7\u5408\u3067\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u304c\u30e1\u30b8\u30e3\u30fc\u306a\u5834\u5408 (\u30aa\u30ec\u30f3\u30b8)\u3002SARS-CoV-2\u306e\u5834\u5408\u306b\u306f\u3001high-mannose \u306f\u57fa\u672c\u7684\u306b3\u5206\u5c90\u3067\u3042\u308a\u3001GlcNAc2-Man5\u20139\u306e\u69cb\u9020\u3068\u306a\u3063\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u4e2d\u3067\u3082\u30e1\u30b8\u30e3\u30fc\u306a\u69cb\u9020\u306fGlcNAc2Man5\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/em><\/p>\n

\u690d\u7269\u3001\u83cc\u985e\u3001\u85fb\u985e\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306a\u3069\u304b\u3089\u62bd\u51fa\u3055\u308c\u305fMannose\u7279\u7570\u7684\u306a\u30ec\u30af\u30c1\u30f3\u306f\u3001\u305d\u308c\u305e\u308c\u306b\u7cd6\u9396\u7d50\u5408\u6027\u306f\u3059\u3053\u3057\u3065\u3064\u7570\u306a\u308b\u304c\u6545\u306b\u3001\u7d50\u679c\u3068\u3057\u3066\u3001\u5404\u7a2e\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3092\u7279\u7570\u7684\u306b\u8a8d\u8b58\u3059\u308b\u3088\u3046\u306a\u30d7\u30ed\u30fc\u30d6\u30fb\u30d1\u30cd\u30eb\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u89b3\u70b9\u304b\u3089\u3001MERS-CoV\u306b\u5bfe\u3057\u3066\u306f\u3001GNA-\u95a2\u9023\u306e\u30ec\u30af\u30c1\u30f3\u3084\u85fb\u985e\u3084\u30b7\u30a2\u30ce\u30d0\u30af\u30c6\u30ea\u30a2\u7531\u6765\u306e\u30ec\u30af\u30c1\u30f3\u304c\u9069\u3057\u3066\u304a\u308a\u3001SARS-CoV\u3084SARS-CoV-2\u306b\u5bfe\u3057\u3066\u306f\u3001trimannoside Man\u03b11,3Man\u03b11,6Man core\u306b\u7279\u7570\u6027\u3092\u6301\u3064\u30de\u30e1\u79d1\u30ec\u30af\u30c1\u30f3\u304c\u9069\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Universit\u00e9 Paul Sabatier, Toulouse, France\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u3001SARS-CoV\u3001MARS-Cov\u306b\u5bfe\u3057\u3066\u6297\u30a6\u30a4\u30eb\u30b9\u52b9\u679c\u3092\u793a\u3059mannose\u7279\u7570\u7684\u306a\u30ec\u30af\u30c1\u30f3\u306b\u3064\u3044<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-4689","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4689"}],"version-history":[{"count":16,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4689\/revisions"}],"predecessor-version":[{"id":5051,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4689\/revisions\/5051"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}