{"id":4683,"date":"2021-07-08T09:07:56","date_gmt":"2021-07-08T00:07:56","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4673"},"modified":"2021-07-08T09:16:27","modified_gmt":"2021-07-08T00:16:27","slug":"sero-positivity-and-neutralizing-activity-of-sars-cov-2-infected-individuals-over-one-year","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/sero-positivity-and-neutralizing-activity-of-sars-cov-2-infected-individuals-over-one-year\/","title":{"rendered":"Sero-positivity and neutralizing activity of SARS-CoV-2 infected individuals over one year"},"content":{"rendered":"

A group from Huazhong University of Science and Technology, Wuhan, China, etc. has reported on sero-positivity and neutralizing activity of SARS-CoV-2 infected individuals over one year.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8242354\/<\/a><\/p>\n

A total of 162 serum samples from 76 SARS-CoV-2-infected individuals including some of the very earliest COVID-19 patients were collected in our study.<\/p>\n

The SARS-CoV-2 Spike- and Nucleocapsid-specific IgM started at intermediate to high levels (96.8 and 54.8%, respectively) early after infection and rapidly and dramatically waned over time. At the end of the one-year observation period, only four cases remained positive for both anti-S and anti-N IgM, resulting in residual positivity rates of 5.3% and 1.3%, respectively. Conversely, the overall sero-positivity for IgG antibodies in convalescent individuals remained very stable with 90.8% and 88.2% sero-positivity for anti-S and anti-N IgG, respectively, persisting for one year<\/p>\n

\"\"<\/a><\/p>\n

SARS-CoV-2-specific neutralizing activity was measured by virus neutralization assays. The results showed that the majority of patients (57.5%) did not exhibit detectable neutralization capacities one year after the symptom onset. The proportion of patients with high titers of neutralizing antibodies (defined by titers exceeding 1:160) was highest 3-4 months after symptom onset. Among the minority of patients who still had detectable nAb (42.5%), most individuals showed rather low nAb titers (\u22641:80). Only very few (5.5%) patients exhibited strong neutralizing titers at or above 1:320.<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Huazhong University of Science and Technology, Wuhan, China, etc. has reported on sero-positivity<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-4683","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4683"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4683\/revisions"}],"predecessor-version":[{"id":4685,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4683\/revisions\/4685"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}