{"id":4607,"date":"2021-07-06T14:37:35","date_gmt":"2021-07-06T05:37:35","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4560"},"modified":"2021-07-06T14:40:33","modified_gmt":"2021-07-06T05:40:33","slug":"decay-of-fc-dependent-antibody-functions-in-covid-19-mild-convalescent-patients","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/decay-of-fc-dependent-antibody-functions-in-covid-19-mild-convalescent-patients\/","title":{"rendered":"Decay of Fc-dependent antibody functions in COVID-19 mild convalescent patients"},"content":{"rendered":"<p>A group from University of Melbourne, Australia, etc. has reported on decay of Fc-dependent antibody functions in COVID-19 mild convalescent patients.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8106889\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8106889\/<\/a><\/p>\n<p>The Fc\u03b3R-binding, antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent phagocytosis (ADP) activities of SARS-CoV-2 Spike-specific antibodies decay during convalescence from COVID-19. The first sample was collected at a median of 41 days post-symptom onset, and the last sample was collected at a median of 123 days post-symptom onset. The decline of plasma ADCC and ADP activity correlated with the decay of SARS-CoV-2 Spike-specific IgG and Fc\u03b3R-binding antibodies (see figure below). <\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Decay-of-Fc-dependent-functions.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Decay-of-Fc-dependent-functions-300x176.png\" alt=\"\" width=\"300\" height=\"176\" class=\"alignleft size-medium wp-image-4563\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Decay-of-Fc-dependent-functions-300x176.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Decay-of-Fc-dependent-functions-600x352.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Decay-of-Fc-dependent-functions.png 668w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Importantly, Fc effector functions were readily detectable above uninfected controls in 94% of subjects for all assays at the last time point sampled, in contrast with neutralization activity, which remained detectable above background for only 70% of subjects. Overall, it seems that mild to moderate COVID-19 generates robust Fc\u03b3R-binding, ADCC, and ADP antibody functions that decay at a slower rate than plasma neutralization activity. \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from University of Melbourne, Australia, etc. has reported on decay of Fc-dependent antibody functions<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/decay-of-fc-dependent-antibody-functions-in-covid-19-mild-convalescent-patients\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-4607","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4607"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4607\/revisions"}],"predecessor-version":[{"id":4609,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4607\/revisions\/4609"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}