{"id":4578,"date":"2021-07-06T13:19:40","date_gmt":"2021-07-06T04:19:40","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4578"},"modified":"2021-07-21T22:56:31","modified_gmt":"2021-07-21T13:56:31","slug":"ace2%e3%80%81tmprss2%e3%81%8c%e7%99%ba%e7%8f%be%e3%81%97%e3%81%a6%e3%81%84%e3%81%aa%e3%81%ab%e3%82%82%e9%96%a2%e3%82%8f%e3%82%89%e3%81%9a%e3%80%81h522-%e8%82%ba%e8%85%ba%e7%99%8c%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/ace2%e3%80%81tmprss2%e3%81%8c%e7%99%ba%e7%8f%be%e3%81%97%e3%81%a6%e3%81%84%e3%81%aa%e3%81%ab%e3%82%82%e9%96%a2%e3%82%8f%e3%82%89%e3%81%9a%e3%80%81h522-%e8%82%ba%e8%85%ba%e7%99%8c%e7%b4%b0%e8%83%9e\/","title":{"rendered":"ACE2\u3001TMPRSS2\u304c\u767a\u73fe\u3057\u3066\u3044\u306a\u306b\u3082\u95a2\u308f\u3089\u305a\u3001H522 \u80ba\u817a\u764c\u7d30\u80de\u306bSARS-CoV-2\u304c\u611f\u67d3\u3059\u308b\uff1a\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\uff1f"},"content":{"rendered":"<p>Washington University in St. Louis, School of Medicine, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u611f\u67d3\u306e\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8220945\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8220945\/<\/a><\/p>\n<p>\u30d2\u30c8\u306e\u80ba\u4e0a\u76ae\u7d30\u80de\u3001\u982d\u9838\u90e8\u304c\u3093\u7d30\u80de\u306b\u304a\u3044\u3066\u306f\u3001ACE2\u3084TMPRSS2\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u5927\u304d\u304f\u5909\u52d5\u3057\u3066\u3044\u307e\u3059\u3002\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30d2\u30c8\u306e\u80ba\u817a\u764c\u3067\u3042\u308bH522\u7d30\u80de\u306b\u306fACE2\u3084TMPRSS2\u304c\u307b\u3068\u3093\u3069\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\u306b\u3082\u95a2\u308f\u3089\u305a\u3001SARS-CoV-2\u304c\u52b9\u7387\u3088\u304f\u611f\u67d3\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u5404\u7a2e\u30a2\u30c3\u30bb\u30a4\u3092\u99c6\u4f7f\u3057\u305f\u7d50\u679c\u3001H522\u7d30\u80de\u306fACE2\u306e\u5b58\u5728\u3068\u306f\u7121\u95a2\u4fc2\u306b\u611f\u67d3\u3057\u3066\u304a\u308a\u3001\u80ba\u7d30\u80de\u7531\u6765\u306e\u4f55\u304b\u3057\u3089\u4ed6\u306e\u53d7\u5bb9\u4f53\u3092\u5229\u7528\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001Neuropin 1 (NRP1)\u3001AXL\u3001\u30d8\u30d1\u30e9\u30f3\u786b\u9178\u3089\u304c\u3001ACE2\u4f9d\u5b58\u306eSARS-CoV-2\u611f\u67d3\u306b\u304a\u3051\u308b\u4ecb\u5728\u5206\u5b50\u3068\u3057\u3066\u8a8d\u77e5\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001Neuropin 1 (NRP1) \u3084 AXL\u306f\u3001\u3053\u306e\u611f\u67d3\u306b\u306f\u95a2\u308f\u3063\u3066\u304a\u3089\u305a\u3001\u30d8\u30d1\u30e9\u30f3\u786b\u9178\u306b\u3064\u3044\u3066\u306f\u3001\u4f9d\u5b58\u6027\u304c\u898b\u3089\u308c\u308b\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/H522cells_SARS-CoV-2_infection.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4588\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/H522cells_SARS-CoV-2_infection-300x199.png\" alt=\"\" width=\"300\" height=\"199\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/H522cells_SARS-CoV-2_infection-300x199.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/H522cells_SARS-CoV-2_infection-600x399.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/H522cells_SARS-CoV-2_infection-1024x681.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/H522cells_SARS-CoV-2_infection-768x510.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/H522cells_SARS-CoV-2_infection.png 1151w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>H522\u7d30\u80de\u3078\u306eSARS-CoV-2\u306e\u611f\u67d3\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63a8\u6e2c\u3059\u308b\u305f\u3081\u306b\u3001SARS-CoV-2\u3078\u306e\u611f\u67d3\u306b\u6f5c\u5728\u7684\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u5019\u88dc\u5206\u5b50\u306e\u5b58\u5728\u4e0b\u3067\u611f\u67d3\u963b\u5bb3\u5b9f\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001camostat mesylate\uff08TMPRSS2 \u963b\u5bb3\u5264\uff09\u3001E64D\uff08\u5e45\u5e83\u3044\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u963b\u5bb3\u5264\u306b\u3066endosomal cathepsin\u3082\u542b\u3080\uff09\u3001bafilomycin A\uff08vATPase \u963b\u5bb3\u5264\uff09\u3001apilimod\uff08PIKfyve \u963b\u5bb3\u5264\uff09\u3001SGC-AAK1-1\uff08AAK1 kinase 1 \u963b\u5bb3\u5264\uff1bAP2\u8907\u5408\u4f53\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3067\u3042\u308bAP2M1\u306e\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3059\u308b\u30af\u30e9\u30b9\u30ea\u30f3\u5a92\u4ecb\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff08CME\uff09\u3092\u4fc3\u9032\u3059\u308b\uff09\u3089\u3067\u3059\u3002<\/p>\n<p>E64D\u3001bafilomycin A\u3001SGC-AAK1-1\u3001apilimod\u306f\u3001\u30c9\u30fc\u30ba\u306b\u4f9d\u5b58\u3057\u305f\u5f62\u3067\u611f\u67d3\u3092\u963b\u5bb3\u3057\u307e\u3057\u305f\u304c\u3001camostat mesylate\u306f\u3001\u9006\u306b\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3092\u52a9\u9577\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u7d50\u679c\u304b\u3089\u3001H522\u7d30\u80de\u306eSARS-CoV-2\u611f\u67d3\u306fCME\u3068endosomal cathepsin\u3092\u4ecb\u3057\u305f\u611f\u67d3\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3042\u308b\u3068\u63a8\u6e2c\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Washington University in St. Louis, School of Medicine, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u611f\u67d3\u306e\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/ace2%e3%80%81tmprss2%e3%81%8c%e7%99%ba%e7%8f%be%e3%81%97%e3%81%a6%e3%81%84%e3%81%aa%e3%81%ab%e3%82%82%e9%96%a2%e3%82%8f%e3%82%89%e3%81%9a%e3%80%81h522-%e8%82%ba%e8%85%ba%e7%99%8c%e7%b4%b0%e8%83%9e\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-4578","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4578"}],"version-history":[{"count":20,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4578\/revisions"}],"predecessor-version":[{"id":5056,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4578\/revisions\/5056"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}