{"id":4572,"date":"2021-07-06T06:50:43","date_gmt":"2021-07-05T21:50:43","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4546"},"modified":"2021-07-06T07:10:54","modified_gmt":"2021-07-05T22:10:54","slug":"characteristics-of-antibodies-targeting-rbd-ntd-and-s2-induced-by-two-times-pfizer-mrna-vaccination","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/characteristics-of-antibodies-targeting-rbd-ntd-and-s2-induced-by-two-times-pfizer-mrna-vaccination\/","title":{"rendered":"Characteristics of antibodies (targeting RBD, NTD, and S2) induced by two times Pfizer mRNA vaccination: Effectiveness against current SARS-CoV-2 variants\u00a0"},"content":{"rendered":"

A group from Icahn School of Medicine at Mount Sinai, New York, USA, etc. has reported on characteristics of Pfizer mRNA vaccinated SARS-CoV-2 antibodies.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8185186\/<\/a><\/p>\n

The antibody response peaked 1 week after the second vaccine dose, followed by a decline in titers over the following weeks as expected from an antibody response to vaccination. Interestingly, titers against the spike proteins of \u03b2-coronaviruses OC43 and HKU1 increased substantially after vaccination.<\/p>\n

RBD and NTD were co-dominant epitopes of the mRNA vaccine-induced antibodies, and the majority of remaining epitopes was mapped to S2. All antibodies were tested for neutralizing activity against the USA-WA1\/2020 strain of SARS-CoV-2. Only a minority of the binding antibodies showed neutralizing activity (see figure below, obtained from three individuals: V1, V5, V6).<\/p>\n

\"\"<\/a><\/p>\n

For sera from the six vaccinated individuals, binding between vaccinee sera and variant RBDs were evaluated. The highest reduction was only 2-fold for E406Q, N440K, E484K, and F490K (see figure below, six vaccinated individuals: V1-V6).
\nThis would be a kind of good news showing that Pfizer mRNA vaccine would be effective against current SARS-CoV-2 variants.<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Icahn School of Medicine at Mount Sinai, New York, USA, etc. has reported on characteristics of P<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-4572","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t