{"id":4491,"date":"2021-07-03T08:55:29","date_gmt":"2021-07-02T23:55:29","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4491"},"modified":"2021-08-22T08:31:04","modified_gmt":"2021-08-21T23:31:04","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%87%e3%83%ab%e3%82%bf%e5%a4%89%e7%95%b0%e6%a0%aa","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%87%e3%83%ab%e3%82%bf%e5%a4%89%e7%95%b0%e6%a0%aa\/","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306b\u304a\u3051\u308b\u30c7\u30eb\u30bf\u5909\u7570\u682a\uff08\u30a4\u30f3\u30c9\u682a\uff1aB.1.617\uff09\u306e\u5909\u7570\u7b87\u6240\uff1a\u4f55\u6545\u3001\u30c7\u30eb\u30bf\u682a\u3067\u611f\u67d3\u529b\u304c\u4e0a\u6607\u3059\u308b\u306e\u304b\uff1f"},"content":{"rendered":"

\u718a\u672c\u5927\u5b66\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u30c7\u30eb\u30bf\u5909\u7570\u682a\uff08\u5225\u540d\u3001\u30a4\u30f3\u30c9\u682a\uff1aB1.617\u7cfb\u7d71\uff09\u306b\u304a\u3044\u3066\u3001\u4f55\u6545\u611f\u67d3\u529b\u304c\u4e0a\u6607\u3059\u308b\u306e\u304b\uff1f\u306b\u3064\u3044\u3066\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.sciencedirect.com\/science\/article\/pii\/S1931312821002845?via%3Dihub<\/a><\/p>\n

L452R \u306f\u3001SARS-CoV-2\u306e\u30c7\u30eb\u30bf\u5909\u7570\u682a\u306b\u304a\u3044\u3066\u307f\u3089\u308c\u308b\u7279\u5fb4\u7684\u306a\u5909\u7570\u3067\u3059\u3002L452R\u5909\u7570\u3067\u306f\u3001\u30d2\u30c8\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u3067\u3042\u308bACE2\u3078\u306e\u7d50\u5408\u529b\u304c\u9855\u8457\u306b\u4e0a\u6607\u3057\u3066\u3044\u307e\u3059\uff08Kd = 1.20 \u00b1 0.06 nM\uff09\u3002L452 \u6b8b\u57fa\u306f\u3001ACE2\u3068\u306e\u7d50\u5408\u306b\u4fc2\u308f\u308b\u76f4\u63a5\u7684\u306a\u5834\u6240\u306b\u306f\u5b58\u5728\u3057\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u304c\uff08\u4e0b\u56f3\u53c2\u7167\uff09\u3001\u3053\u306e\u69cb\u9020\u89e3\u6790\u3068\u5206\u5b50\u52d5\u529b\u5b66\u7684\u306a\u8003\u5bdf\u306b\u3088\u308c\u3070\u3001L452R\u5909\u7570\u306f\u3001\u9759\u96fb\u7684\u306a\u76f8\u88dc\u6027\u3092\u52a9\u9577\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u3068\u3044\u3046\u306e\u3082\u3001\u7d50\u5408\u306b\u95a2\u4e0e\u3059\u308bACE2\u306e\u6b8b\u57fa\uff08E35\u3001E37\u3001D38\uff09\u306e\u9818\u57df\u306f\u8ca0\u306b\u5e2f\u96fb\u3057\u3066\u304a\u308a\u3001452\u6b8b\u57fa\u306f\u305d\u306e\u8fd1\u508d\u306b\u5b58\u5728\u3059\u308b\u304b\u3089\u3067\u3059\u3002\u5373\u3061\u3001ACE2\u3068\u306e\u9759\u96fb\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u6b63\u306b\u5e2f\u96fb\u3057\u305fR452\u6b8b\u57fa\u306e\u65b9\u304c\u3001\u9759\u96fb\u7684\u306b\u4e2d\u7acb\u306aL452\u6b8b\u57fa\u3088\u308a\u3082\u5f53\u7136\u306a\u304c\u3089\u5f37\u304f\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

L452R \u5909\u7570\u304c\u3001SARS-CoV-2\u306e\u5bbf\u4e3b\u7d30\u80de\u3068\u306e\u878d\u5408\u52b9\u7387\u3092\u62bc\u3057\u4e0a\u3052\u308b\u3053\u3068\u3082\u3001SARS-CoV-2 Spike\u30d9\u30fc\u30b9\u306e\u878d\u5408\u30a2\u30c3\u30bb\u30a4\u3092\u7528\u3044\u3066\u793a\u3055\u308c\u307e\u3057\u305f\u3002L452R \u5909\u7570\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u7d30\u80de\u819c\u878d\u5408\u52b9\u7387\u3092\u62bc\u3057\u4e0a\u3052\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u3082\u52a9\u3051\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\uff08\u4e0b\u56f3\u53c2\u7167\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u718a\u672c\u5927\u5b66\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u30c7\u30eb\u30bf\u5909\u7570\u682a\uff08\u5225\u540d\u3001\u30a4\u30f3\u30c9\u682a\uff1aB1.617\u7cfb\u7d71\uff09\u306b\u304a\u3044\u3066\u3001\u4f55\u6545\u611f\u67d3\u529b\u304c\u4e0a\u6607\u3059\u308b\u306e\u304b\uff1f\u306b\u3064\u3044\u3066\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002 https:\/\/www.sciencedirect.com\/sci<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-4491","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4491"}],"version-history":[{"count":13,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4491\/revisions"}],"predecessor-version":[{"id":5060,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4491\/revisions\/5060"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}