{"id":4475,"date":"2021-07-01T11:24:50","date_gmt":"2021-07-01T02:24:50","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4454"},"modified":"2021-07-01T12:00:33","modified_gmt":"2021-07-01T03:00:33","slug":"relationship-between-cholesterol-and-severity-of-covid-19-the-lower-the-cholesterol-the-higher-the-severity","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/relationship-between-cholesterol-and-severity-of-covid-19-the-lower-the-cholesterol-the-higher-the-severity\/","title":{"rendered":"Relationship between Cholesterol and Severity of COVID-19: \u00a0the lower the cholesterol, the higher the severity"},"content":{"rendered":"<p>In the case of COVID-19, it is said that the lower the cholesterol, the higher the severity.<\/p>\n<p>A group from Malm\u00f6 University, Sweden, etc. has reported that the Spike protein removes lipids and cholesterol from model membranes, and upon co-incubation of both the SARS-CoV-2 spike protein and HDL on model membranes, the levels of lipid removal from the membrane was suppressed, from experiments using model membranes and through interactions with SARS-CoV-2 Spike with and without HDL.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8195693\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8195693\/<\/a><\/p>\n<p>This suggests that the higher the concentration of cholesterol existing on the membrane and in serum, the lower the adsorption of SARS-CoV-2 spike onto the membrane, in other words, the higher the cholesterol, the lower the infectivity.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Cholesteryl_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Cholesteryl_SARS-CoV-2-300x173.png\" alt=\"\" width=\"300\" height=\"173\" class=\"alignleft size-medium wp-image-4469\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Cholesteryl_SARS-CoV-2-300x173.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Cholesteryl_SARS-CoV-2-600x346.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Cholesteryl_SARS-CoV-2-768x443.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Cholesteryl_SARS-CoV-2.png 868w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Incidentally, the model membrane used here was deuterated 1,2-dimyristoyl-D54-3-sn-glycerophosphatidylcholine (dDMPC) and perdeuterated cholesterol (dcholesterol) at a molar ratio of 80:20 mol%.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the case of COVID-19, it is said that the lower the cholesterol, the higher the severity. A group from Malm<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/relationship-between-cholesterol-and-severity-of-covid-19-the-lower-the-cholesterol-the-higher-the-severity\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-4475","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4475"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4475\/revisions"}],"predecessor-version":[{"id":4478,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4475\/revisions\/4478"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}