{"id":4452,"date":"2021-07-02T08:40:53","date_gmt":"2021-07-01T23:40:53","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4452"},"modified":"2021-07-21T22:58:14","modified_gmt":"2021-07-21T13:58:14","slug":"%e7%99%ba%e7%86%b1%e3%81%a8%e3%81%a8%e3%82%82%e3%81%abtransient-receptor-potential-vanilloid-2-trpv2%e3%82%92%e4%bb%8b%e3%81%97%e3%81%a6sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%81%8c%e5%8a%a0","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e7%99%ba%e7%86%b1%e3%81%a8%e3%81%a8%e3%82%82%e3%81%abtransient-receptor-potential-vanilloid-2-trpv2%e3%82%92%e4%bb%8b%e3%81%97%e3%81%a6sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%81%8c%e5%8a%a0\/","title":{"rendered":"\u767a\u71b1\u3068\u3068\u3082\u306bTransient receptor potential vanilloid 2 (TRPV2)\u3092\u4ecb\u3057\u3066SARS-CoV-2\u306e\u611f\u67d3\u304c\u52a0\u901f\u3059\u308b\uff1a\u65b0\u3057\u3044\u611f\u67d3\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u767a\u898b"},"content":{"rendered":"<p>Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, China\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u767a\u71b1\u4e0b\u3067\u306e\u65b0\u898fSARS-CoV-2\u611f\u67d3\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8210595\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8210595\/<\/a><\/p>\n<p>Transient receptor potential vanilloid 2 (TRPV2) \u306f\u3001\u3082\u3068\u3082\u3068\u6e29\u5ea6\u306b\u654f\u611f\u306a\u5206\u5b50\u3068\u3057\u3066\u5206\u96e2\u767a\u898b\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002TRPV2\u306f\u3001\u81ea\u7136\u514d\u75ab\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u901a\u5e38\u306f\u5c0f\u80de\u4f53\u306b\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u3001\u6210\u9577\u56e0\u5b50\u3001\u30b1\u30e2\u30ab\u30a4\u30f3\u3068\u3044\u3063\u305f\u3088\u3046\u306a\u3042\u308b\u7a2e\u306e\u523a\u6fc0\u304c\u5165\u3063\u305f\u72b6\u614b\u3067\u306f\u3001TRPV2\u304c\u5c0f\u80de\u4f53\u304b\u3089\u7d30\u80de\u819c\u306b\u79fb\u52d5\u3057\u3001Ca2+ \u306e\u7d30\u80de\u5185\u8f38\u9001\u3092\u4fc3\u3059\u3068\u3068\u3082\u306b\u64ec\u8db3\u306e\u767a\u751f\u3082\u4fc3\u3057\u307e\u3059\u3002\u64ec\u8db3\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u708e\u75c7\u90e8\u3078\u306e\u79fb\u52d5\u3092\u52a9\u3051\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u98df\u4f5c\u7528\u3092\u4fc3\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u306eTRPV2 \u304cSARS-CoV-2\u306e\u611f\u67d3\u306b\u4fc2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u306e\u3067\u3059\u3002PBAM\u3001\u30d2\u30c8THP-1 \u7d30\u80de\u3001\u30de\u30a6\u30b9\u30fb\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08RAW264.7\uff09\u3092\u4f7f\u7528\u3057\u305fSARS-CoV-2 Spike\u3068\u306eco-IP\u30a2\u30c3\u30bb\u30a4\u3092\u300137 \u00b0C \u3068 39.5 \u00b0C \u3068\u3044\u3046\u4e8c\u3064\u306e\u6e29\u5ea6\u6761\u4ef6\u3067\u884c\u3044\u3001TRPV2 \u3068 SARS-CoV-2 Spike\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001TRPV2 \u3068 SARS-CoV-2 Spike\u3068\u306e\u53cd\u5fdc\u304c\u300137 \u00b0C\u3067\u306f\u8d77\u3053\u3089\u306a\u3044\u304c\u300139.5 \u00b0C\u3067\u306f\u5f37\u304f\u8d77\u3053\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3001<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TRPV2-Spike_39.5C.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TRPV2-Spike_39.5C-300x86.png\" alt=\"\" width=\"300\" height=\"86\" class=\"alignleft size-medium wp-image-4479\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TRPV2-Spike_39.5C-300x86.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TRPV2-Spike_39.5C-600x172.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TRPV2-Spike_39.5C-1024x294.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TRPV2-Spike_39.5C-768x220.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TRPV2-Spike_39.5C.png 1056w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>39.5 \u00b0C \u3068\u3044\u3046\u767a\u71b1\u306f\u3001\u9855\u8457\u306b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u7531\u6765\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u5206\u6ccc\u3092\u5897\u5f37\u3057\u307e\u3057\u305f\u3001IFN-\u03b1\u3001IFN-\u03b3\u3001IL-13\u3001IL-\u03b1\u3001TNF-\u03b1\u3001IL-10\u3001IL-18\u3001IL-2\u3001IL-4\u3001IL-17A\u3001MCP-1\u3001IL-15 \u306a\u3069\u3067\u3059\u3002\u3057\u304b\u3082\u3001\u3053\u306e\u73fe\u8c61\u306f\u3001 ACE2\u3084NP-1\u306e\u5b58\u5728\u3068\u306f\u7121\u95a2\u4fc2\u306b\u8d77\u3053\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u66f4\u306b\u3001TRPV2 \u306e\u963b\u5bb3\u5264\u3067\u3042\u308bSKF-96365 \u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u5206\u6ccc\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u51fa\u6765\u308b\u304b\u306b\u3064\u3044\u3066\u691c\u8a3c\u304c\u884c\u308f\u308c\u3001\u767a\u71b1\u4e0b\u306b\u304a\u3044\u3066\u306f\u3001SFK-96365\u304c\u52b9\u679c\u7684\u306b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u5206\u6ccc\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u3001\u8457\u8005\u3089\u306f\u767a\u71b1\u4e0b\u306b\u304a\u3051\u308b\u65b0\u898f\u306eSARS-CoV-2\u611f\u67d3\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u767a\u898b\u3059\u308b\u3068\u540c\u6642\u306b\u3001SKF-96365\u304cSARS-CoV-2\u306e\u767a\u71b1\u4e0b\u3067\u306e\u6cbb\u7642\u85ac\u306b\u306a\u308a\u5f97\u308b\u3068\u3044\u3046\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources i<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e7%99%ba%e7%86%b1%e3%81%a8%e3%81%a8%e3%82%82%e3%81%abtransient-receptor-potential-vanilloid-2-trpv2%e3%82%92%e4%bb%8b%e3%81%97%e3%81%a6sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%81%8c%e5%8a%a0\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":11,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":5061,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4452\/revisions\/5061"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}