{"id":4409,"date":"2021-06-28T10:42:34","date_gmt":"2021-06-28T01:42:34","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4409"},"modified":"2021-07-21T22:59:58","modified_gmt":"2021-07-21T13:59:58","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88covid-19%ef%bc%89%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%b3%96%e9%8e%96%e3%81%a8%e3%83%ac%e3%82%af%e3%83%81","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88covid-19%ef%bc%89%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%b3%96%e9%8e%96%e3%81%a8%e3%83%ac%e3%82%af%e3%83%81\/","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u306b\u304a\u3051\u308b\u7cd6\u9396\u3068\u30ec\u30af\u30c1\u30f3\u306e\u4fc2\u308a\u3092\u8ffd\u3046\uff1aSARS-CoV-2\u306e\u611f\u67d3\u3068\u91cd\u75c7\u5316\u306b\u7d61\u3093\u3067"},"content":{"rendered":"

\u672c\u30d6\u30ed\u30b0\u7b46\u8005\u304c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306b\u95a2\u3059\u308b\u8ad6\u6587\u6982\u8aac\u8a18\u4e8b\u3092\u66f8\u304d\u59cb\u3081\u3066\u304b\u3089\u3001\u3082\u3046\u76f4\u30501\u5e74\u306b\u306a\u308d\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u8a18\u4e8b\u3092\u66f8\u304d\u59cb\u3081\u305f\u306e\u306f2020\u5e74\u306e7\u6708\u3067\u3001GlycoTechnica\u306eOfficial blog\u30b5\u30a4\u30c8\u3067\u3057\u305f\u304c\u3001\u540c\u5e7410\u6708\u4ee5\u964d\u306fMx\u306e\u30d6\u30ed\u30b0\u30b5\u30a4\u30c8\u306b\u5834\u6240\u3092\u79fb\u3057\u3066\u66f8\u304d\u7d9a\u3051\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u306b\u304a\u3051\u308b\u7cd6\u9396\u3068\u30ec\u30af\u30c1\u30f3\u306e\u4fc2\u308a\u306b\u3064\u3044\u3066\u3001\u3059\u3079\u3066\u304c\u89e3\u660e\u3055\u308c\u305f\u3068\u306f\u3068\u3066\u3082\u8a00\u3048\u306a\u3044\u72b6\u6cc1\u3067\u3059\u304c\u3001\u30dd\u30a4\u30f3\u30c8\u306f\u6574\u7406\u3055\u308c\u3066\u304d\u305f\u611f\u3058\u304c\u3057\u307e\u3059\u306e\u3067\u3001\u3053\u306e\u3042\u305f\u308a\u3067\u4e00\u56de\u300c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u306b\u304a\u3051\u308b\u7cd6\u9396\u3068\u30ec\u30af\u30c1\u30f3\u306e\u4fc2\u308a<\/strong>\u300d\u306b\u3064\u3044\u3066\u3001\u7b46\u8005\u306a\u308a\u306e\u898b\u89e3\u3092\u307e\u3068\u3081\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

SARS-CoV-2\u306f\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u3092\u6301\u3064\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308a\u3001\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u306b\u306f\u3001S (\u30b9\u30d1\u30a4\u30af)\u3001M (\u30de\u30c8\u30ea\u30c3\u30af\u30b9)\u3001E (\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7)\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u611f\u67d3\u306b\u304b\u304b\u308f\u308b\u306e\u306f\u3001\u4e3b\u306b\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u975e\u5e38\u306b\u591a\u304f\u306e\u7cd6\u9396\u4fee\u98fe\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u300122\u500b\u306eN-\u578b\u7cd6\u9396\u4fee\u98fe\u90e8\u4f4d\u30016\u500b\u306eO-\u578b\u7cd6\u9396\u4fee\u98fe\u90e8\u4f4d\u304c\u3042\u308a\u307e\u3059\u3002 Oligomannose-\u578b\u306e\u7cd6\u9396\u306f\u30012\u30b1\u6240\uff08N234 \u3068 N709\uff09\u3001\u8907\u5408\u578b\u7cd6\u9396\u306f\u3001\u4e3b\u306b14\u30b1\u6240\uff08N17\u3001N74\u3001N149\u3001N165\u3001N282\u3001N331\u3001N343\u3001N616\u3001N657\u3001 N1098\u3001N1134\u3001N1158\u3001N1173 \u304a\u3088\u3073 N1194\uff09\u3001\u66f4\u306b6\u30f6\u6240\u306f\u3001oligomannose-\u578b\u3068\u8907\u5408\u578b\u304c\u6df7\u5728\u3057\u3066\u3044\u307e\u3059\uff08N61\u3001N122\u3001N603\u3001N717\u3001N801\u3001N1074\uff09\u3002\u6700\u3082\u666e\u901a\u306b\u307f\u3089\u308c\u308boligomannose-\u578b\u7cd6\u9396\u306f\u3001 Man5GlcNAc2\u3067\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001O-\u578b\u7cd6\u9396\u306f\u77ed\u9396\u306b\u3066\u3001Tn\u3084core1\u69cb\u9020\u304c\u4e3b\u3067\u3042\u308a\u307e\u3059\uff08T73\u3001T76\u3001T478\u3001T676\u3001T678, \u304a\u3088\u3073T1076\uff09\u3002<\/p>\n

\u305d\u308c\u3067\u306f\u3001\u7cd6\u9396\u306e\u6a5f\u80fd\u3068\u306f\u4e00\u4f53\u4f55\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong>\u4e00\u822c\u7684\u306a\u8a8d\u8b58\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u30d2\u30c8\u306e\u514d\u75ab\u7cfb\u3092\u56de\u907f\u3059\u308b\u305f\u3081\u306b\u307e\u3068\u3063\u305f\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b7\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0<\/strong>\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u7cd6\u9396\u306f\u975e\u5e38\u306b\u9ad8\u901f\u306b\u63fa\u308c\u52d5\u3044\u3066\u304a\u308a\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u8fd1\u3065\u304f\u514d\u75ab\u7d30\u80de\u3092\u5237\u6bdb\u3067\u632f\u308a\u6255\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u30a4\u30e1\u30fc\u30b8\u3067\u3057\u3087\u3046\u3002\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u611f\u67d3\u5bbf\u4e3b\u7d30\u80de\u306e\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308bS1\u30c9\u30e1\u30a4\u30f3\u3068\u3001\u7d30\u80de\u819c\u3068\u306e\u878d\u5408\u306b\u95a2\u4e0e\u3059\u308bS2\u30c9\u30e1\u30a4\u30f3\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u304c\u3001S2\u30c9\u30e1\u30a4\u30f3\u306f\u3001\u307b\u307c100\uff05\u8fd1\u304f\u7cd6\u9396\u30b7\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306b\u3088\u3063\u3066\u5b88\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u5bbf\u4e3b\u7d30\u80de\u306b\u5b58\u5728\u3059\u308bACE2\u3092\u611f\u67d3\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u7d50\u5408\u90e8\u4f4d\u3092RBD\u3068\u547c\u3073\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001Arg319\u2013Phe541\u306e\u30c9\u30e1\u30a4\u30f3\u304cACE2\u306b\u7d50\u5408\u3059\u308bSARS-CoV-2 RBD\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306eRBD\u5185\u306b\u306f\u3001N331\u3001 N343\u306e\u4e8c\u30b1\u6240\u306bN-\u578b\u7cd6\u9396\u4fee\u98fe\u4f4d\u7f6e\u304c\u5b58\u5728\u3057\u3001\u5bbf\u4e3b\u7d30\u80de\u306eACE2\u3082\u3082\u3061\u308d\u3093\u7cd6\u9396\u4fee\u98fe\u3092\u53d7\u3051\u3066\u304a\u308a\u3001N53\u3001N90\u3001N103\u3001N322\u3001N432\u3001N546\u306e6\u30f6\u6240\u306bN-\u578b\u7cd6\u9396\u4fee\u98fe\u4f4d\u7f6e\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u7cd6\u9396\u4fee\u98fe\u306f\u3001RBD\u3068ACE2\u306e\u7d50\u5408\u306b\u5927\u304d\u306a\u5f71\u97ff\u306f\u4e0e\u3048\u3066\u3044\u306a\u3044\u3068\u3055\u308c\u3001ACE2\u304b\u3089N-\u578b\u7cd6\u9396\u3092\u9664\u53bb\u3059\u308b\u3068\u82e5\u5e72\u3067\u3059\u304c\u611f\u67d3\u529b\u304c\u4e0a\u304c\u308b\u3068\u3055\u308c\u3001\u30b7\u30a2\u30eb\u9178\u3084oligomannose\u306f\u611f\u67d3\u529b\u3092\u82e5\u5e72\u5f31\u3081\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306eO-\u578b\u7cd6\u9396<\/strong>\u306b\u3064\u3044\u3066\u306f\u3001\u5927\u5909\u8208\u5473\u6df1\u3044\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002SARS-CoV-2\u306eS\u30bf\u30f3\u30d1\u30af\u8cea\u306eS1\/S2\u5883\u754c\u306b\u306f\u3001PRRA\uff08P681-A684\uff09\u3068\u3044\u3046\u914d\u5217\u304c\u633f\u5165\u3055\u308c\u3066\u304a\u308a\u3001furin cleavage site\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8fd1\u508d\u306b\u306fO\u578b\u7cd6\u9396\u304c\u4fee\u98fe\u3055\u308c\u308b\u4f4d\u7f6e\u3068\u3057\u3066\u3001S673\u3001T676\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u4f4d\u7f6e\u306bO\u578b\u7cd6\u9396\u4fee\u98fe\u304c\u8d77\u3053\u308b\u306b\u306f\u3001681\u306eproline\u306e\u5b58\u5728\u304c\u6df1\u304f\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u82f1\u56fd\u5909\u7570\u682a\uff08B.1.1.7\uff09\u3067\u306f\u3001P681H\u3068\u3044\u3046\u5909\u7570\u304c\u5165\u3063\u3066\u304a\u308a\u3001proline\u304chistidine\u306b\u7f6e\u63db\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u70ba\u3001\u82f1\u56fd\u5909\u7570\u682a\u3067\u306f681\u306bproline\u304c\u5b58\u5728\u3057\u306a\u3044\u3053\u3068\u3067\u3001S63\u3001T676\u306eO\u578b\u7cd6\u9396\u4fee\u98fe\u304c\u6291\u5236\u3055\u308c\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066furin cleavage site\u306e\u5207\u65ad\u52b9\u7387\u304c\u4e0a\u6607\u3057\u3001\u611f\u67d3\u529b\u306e\u30a2\u30c3\u30d7\u306b\u7e4b\u304c\u3063\u3066\u3044\u308b\u3068\u63a8\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

SARS-CoV-2\u306e\u611f\u67d3\u306b\u304a\u3044\u3066\u306f\u3001ACE2\u304c\u6b63\u898f\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30d2\u30c8\u306e\u80ba\u4e0a\u76ae\u7d30\u80de\u306b\u306f\u307b\u3068\u3093\u3069\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u304c\u3001\u3042\u308b\u610f\u5473\u7269\u8b70\u3092\u91b8\u3057\u3060\u3057\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001ACE2\u3092\u4ecb\u3059\u308b\u611f\u67d3\u4ee5\u5916\u306b\u7b2c\u4e8c\u3001\u7b2c\u4e09\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u304c\u5b58\u5728\u3059\u308b\u306f\u305a\u3060\uff01\uff1f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002C-\u578b\u30ec\u30af\u30c1\u30f3\uff08DC-SIGN\u3001L-SIGN\u3001MGL\u3001Langerin\uff09\u304c\u7740\u76ee\u3055\u308c\u308b\u7406\u7531<\/strong>\u306f\u3053\u3053\u306b\u3042\u308a\u307e\u3059\u3002C-\u578b\u30ec\u30af\u30c1\u30f3\u306f\u30012\u7a2e\u985e\u306e\u7d50\u5408\u30e2\u30c1\u30fc\u30d5\u3092\u6301\u3061\u3001mannose\u306b\u7279\u7570\u6027\u3092\u6301\u3064\u3082\u306e\u3068\u3001Gal\/GalNAc\u306b\u7279\u7570\u6027\u3092\u6301\u3064\u3082\u306e\u304c\u5b58\u5728\u3057\u307e\u3059\u3002SARS-CoV-2\u306e\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u8907\u5408\u578b\u3092\u4e3b\u6d41\u3068\u3059\u308b\u3082\u306e\u306e\u3001Man5GlcNAc2\u3092\u4e3b\u8981\u306a\u69cb\u9020\u3068\u3057\u3066oligomannose\u69cb\u9020\u3082\u6301\u3064\u304c\u6545\u306b\u3001C-\u578b\u30ec\u30af\u30c1\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u5fc5\u305a\u3084\u5b58\u5728\u3059\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3057\u3001\u5b9f\u9a13\u7684\u306b\u3082\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u3068C-\u578b\u30ec\u30af\u30c1\u30f3\u304c\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u66f4\u306b\u8208\u5473\u6df1\u3044\u306e\u306f\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306eNTD\u306b\u5b58\u5728\u3059\u308b\u30ac\u30ec\u30af\u30c1\u30f3\u69d8\u69cb\u9020\uff08\u03b2-sheet structures\uff09<\/strong>\u3067\u3059\u3002NTD\u304cA\u6297\u539fType1\u306b\u7d50\u5408\u3059\u308b\u3068\u3044\u3046\u7d50\u679c\u304c\u7cd6\u9396\u30a2\u30ec\u30a4\u3092\u7528\u3044\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u66f4\u306b\u306f\u3001A\u6297\u539fType4\u306b\u3082\u7d50\u5408\u3057\u3001lactosamin\u306b\u3082\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u6301\u3064\u3053\u3068\u304c\u540c\u69d8\u306b\u7cd6\u9396\u30a2\u30ec\u30a4\u3092\u7528\u3044\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001ABO\u8840\u6db2\u578b\u3068\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u95a2\u4fc2\u6027\u306b\u304a\u3044\u3066\u3001O\u578b\u306e\u30d2\u30c8\u306b\u6bd4\u3079\u3066A\u578b\u306e\u30d2\u30c8\u306e\u65b9\u304c\u611f\u67d3\u3057\u3084\u3059\u3044\u3068\u3044\u3046\u3053\u3068\u3092\u898b\u4e8b\u306b\u8aac\u660e\u3057\u3066\u304f\u308c\u307e\u3059\u3002\u3064\u307e\u308aSARS-CoV-2\u304cA\u6297\u539f\u306b\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u6301\u3061\u3001O\u578b\u306e\u30d2\u30c8\u306f\u6297A\u6297\u4f53\u3092\u6301\u3064\u306e\u3067\u3001SARS-CoV-2\u306e\u611f\u67d3\u3092\u963b\u5bb3\u3067\u304d\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u8a71\u306b\u7d61\u3093\u3067\u3001\u81ea\u7136\u6297\u4f53\u3068\u3057\u3066\u306e\u6297Tn\uff08\u03b1GalNAc\uff09\u6297\u4f53\u304c\u5c11\u306a\u3044\u3068SARS-CoV-2\u306b\u611f\u67d3\u3057\u3084\u3059\u3044\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u3001SARS-CoV-2\u3068\u03b1GalNAc\u3092\u3081\u3050\u308b\u76f8\u4e92\u4f5c\u7528<\/strong>\u304c\u76ca\u3005\u7740\u76ee\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u3088\u3046\u306a\u5b9f\u9a13\u7d50\u679c\u306f\u3001ACE2\u3092\u4e2d\u5fc3\u306b\u3057\u305f\u611f\u67d3\u30e2\u30c7\u30eb\u4ee5\u5916\u306b\u3001\u5bbf\u4e3b\u7d30\u80de\u306b\u767a\u73fe\u3059\u308bC-\u578b\u30ec\u30af\u30c1\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3084\u3001SARS-CoV-2\u306eNTD\u3068\u5bbf\u4e3b\u7d30\u80de\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u03b1GalNAc\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u5f15\u304d\u91d1\u3068\u3057\u3066\u611f\u67d3\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3068\u3044\u3046\u30e2\u30c7\u30eb\u306e\u5b58\u5728\u3092\u5f37\u304f\u793a\u5506\u3057\u3001\u66f4\u306b\u306f\u3001\u6a39\u72b6\u7d30\u80de\u3084\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3089\u306b\u9ad8\u767a\u73fe\u3059\u308bC-\u578b\u30ec\u30af\u30c1\u30f3\u3092\u4ecb\u3057\u305fSARS-CoV-2\u306e\u76f4\u63a5\u611f\u67d3\u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u3092\u5f15\u304d\u8d77\u3053\u3059\u5207\u3063\u639b\u3051\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u4e8b\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/p>\n

\u6b21\u306bSARS-CoV-2\u306b\u5bfe\u3059\u308b\u4e2d\u548c\u6297\u4f53\u306e\u8a71\u306b\u8ad6\u70b9\u3092\u79fb\u3057\u307e\u3057\u3087\u3046\u3002COVID-19\u306e\u56de\u5fa9\u671f\u60a3\u8005\u304b\u3089\u5f97\u3089\u308c\u308b\u6297\u4f53\u306f\u3001RBD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u30c9\u30e1\u30a4\u30f3\u3068\u3057\u3066\u3044\u308b\u3082\u306e\u304c\u7d0435%\u3001NTD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u30c9\u30e1\u30a4\u30f3\u3068\u3057\u3066\u3044\u308b\u3082\u306e\u304c\u7d0433\uff05\u3001\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306eNTD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u6297\u4f53\u306e\u5185\u3001\u5c11\u306a\u3044\u3067\u3059\u304c\u3001\u30da\u30d7\u30c1\u30c9\u90e8\u5206\u306e\u307f\u3067\u306a\u304f\u7cd6\u9396\u4fee\u98fe\uff08LacNAc\u3068\u305d\u306e\u03b12-3Sia\u4fee\u98fe\uff09\u3082\u540c\u6642\u306b\u8a8d\u8b58\u3057\u3066\u3044\u308b\u6297\u4f53\u304c\u5b58\u5728\u3057\u3066\u3044\u308b<\/strong>\u3068\u306e\u3053\u3068\u3067\u3059\u3001\u8208\u5473\u6df1\u3044\u3067\u3059\u3002<\/p>\n

IgG\u306e\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u8131\u4fee\u98fe\u304cCOVID-19\u306e\u91cd\u75c7\u5316\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b<\/strong>\u3068\u3044\u3046\u8a71\u306f\u3001\u66f4\u306b\u9762\u767d\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002IgG\u306ecore fucose\u4fee\u98fe\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3001effector\u52b9\u679c\uff08ADCC\u3084ADP\uff09\u304c\u5897\u5f37\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u826f\u3044\u65b9\u5411\u306b\u50cd\u3051\u3070\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u6392\u9664\u3092\u52a0\u901f\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u5834\u5408\u306b\u306f\u3001IgG\u306ecore fucose\u306e\u6e1b\u5c11\u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u306e\u5f15\u304d\u91d1\u3092\u5f15\u304d\u3001\u7d44\u7e54\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u3066\u3057\u307e\u3046\u5834\u5408\u304c\u3042\u308b\u3088\u3046\u306a\u306e\u3067\u3059\u3002\u3053\u308c\u306fIgG\u3068SARS-CoV-2\u306e\u8907\u5408\u4f53\u304cFc\u03b3\u53d7\u5bb9\u4f53\u3068\u7d50\u5408\u3057\u3001\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u3067\u98df\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u30a6\u30a4\u30eb\u30b9\u304c\u9006\u306b\u98df\u7d30\u80de\u306b\u611f\u67d3\u3057\u305f\u3068\u3044\u3046\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u7cd6\u9396\u3068\u30ec\u30af\u30c1\u30f3\u3068\u306e\u963b\u5bb3\u5264\uff08\u591a\u7cd6\u985e\u3084Fc\u878d\u5408\u30ec\u30af\u30c1\u30f3\uff09\u3001\u6216\u3044\u306f\u7cd6\u8ee2\u79fb\u9175\u7d20\u3092\u72d9\u3063\u305f\u7cd6\u9396\u4fee\u98fe\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3082COVID-19\u306e\u6cbb\u7642\u306b\u5bfe\u3057\u3066\u6709\u52b9\u306a\u624b\u6bb5\u306b\u306a\u308a\u5f97\u308b\u306e\u3067\u306f\u306a\u3044\u304b\uff1f\u3068\u3044\u3046\u3053\u3068\u3092\u6559\u3048\u3066\u304f\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u672c\u30d6\u30ed\u30b0\u7b46\u8005\u304c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306b\u95a2\u3059\u308b\u8ad6\u6587\u6982\u8aac\u8a18\u4e8b\u3092\u66f8\u304d\u59cb\u3081\u3066\u304b\u3089\u3001\u3082\u3046\u76f4\u30501\u5e74\u306b\u306a\u308d\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u8a18\u4e8b\u3092\u66f8\u304d\u59cb\u3081\u305f\u306e\u306f2020\u5e74\u306e7\u6708\u3067\u3001GlycoTechnica\u306eOfficial blo<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-4409","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4409"}],"version-history":[{"count":19,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4409\/revisions"}],"predecessor-version":[{"id":4892,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4409\/revisions\/4892"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4409"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4409"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}