{"id":4380,"date":"2021-06-29T09:57:37","date_gmt":"2021-06-29T00:57:37","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4380"},"modified":"2021-07-21T22:59:18","modified_gmt":"2021-07-21T13:59:18","slug":"sars-cov-2-%e3%81%ae%e9%9d%9e%e6%a7%8b%e9%80%a0%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%a7%e3%81%82%e3%82%8b-nsp1-%e3%81%a8-nsp13-%e3%81%8c%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%95","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2-%e3%81%ae%e9%9d%9e%e6%a7%8b%e9%80%a0%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%a7%e3%81%82%e3%82%8b-nsp1-%e3%81%a8-nsp13-%e3%81%8c%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%95\/","title":{"rendered":"SARS-CoV-2 \u306e\u975e\u69cb\u9020\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b NSP1 \u3068 NSP13 \u304c\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u3001\u30d2\u30c8\u306e\u81ea\u7136\u514d\u75ab\u3092\u6291\u3048\u8fbc\u3093\u3067\u3044\u308b"},"content":{"rendered":"<p>University of Pennsylvania Perelman School of Medicine, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u975e\u69cb\u9020\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bNSP1\u3068NSP13\u304c\u305d\u308c\u305e\u308c\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u3001\u30d2\u30c8\u306e\u81ea\u7136\u514d\u75ab\u3092\u6291\u3048\u8fbc\u3093\u3067\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0253089\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0253089<\/a><\/p>\n<p>\u81ea\u7136\u514d\u75ab\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u4f5c\u7528\u306f\u30a6\u30a4\u30eb\u30b9\u6027\u75c5\u539f\u83cc\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u306e\u6700\u521d\u306e\u969c\u58c1\u3067\u3059\u3002RNA\u30a6\u30a4\u30eb\u30b9\u304c\u611f\u67d3\u3059\u308b\u3068\u3001\u30a6\u30a4\u30eb\u30b9RNA\u3084\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u8a00\u3063\u305f\u30a6\u30a4\u30eb\u30b9\u75c5\u539f\u4f53\u95a2\u9023\u5206\u5b50\u30d1\u30bf\u30fc\u30f3\uff08PAMP\uff09\u304c\u3001RIG-I\u3001MDA5\u3001TLR\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306a\u3069\u306e\u30b5\u30a4\u30c8\u30be\u30eb\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\u306b\u3088\u3063\u3066\u611f\u77e5\u3055\u308c\u307e\u3059\u3002RIG-I\u3068\u30a6\u30a4\u30eb\u30b9RNA\u306e\u7d50\u5408\u306f\u3001\u4e2d\u5fc3\u7684\u306a\u81ea\u7136\u514d\u75ab\u30a2\u30c0\u30d7\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bMitochondrial antiviral-signaling protein\uff08MAVS\uff09\u3092\u4ecb\u3057\u3066\u4e0b\u6d41\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u958b\u59cb\u3057\u307e\u3059\u3002\u4e00\u65e6MAVS\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u30ad\u30ca\u30fc\u30bc\u3067\u3042\u308b Tank-binding kinase 1\uff08TBK1\uff09\u3068 I-kappa-B epsilon kinase\uff08IKK\u03b5\uff09\u304c\u3001Interferon Regulatory Factor 3\uff08IRF3\uff09\u3092\u30ea\u30f3\u9178\u5316\u3057\u3001\u305d\u306e\u6838\u79fb\u884c\u304a\u3088\u3073IFN-\u03b2\u306e\u8ee2\u5199\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u5206\u6ccc\u3055\u308c\u305fIFN-\u03b2\u306f\u3001\u96a3\u63a5\u3059\u308b\u7d30\u80de\u306eIFN-\u0251\/\u03b2\u53d7\u5bb9\u4f53\uff08IFNAR\uff09\u306b\u7d50\u5408\u3057\u3001\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u5fdc\u7b54\u3092\u958b\u59cb\u3057\u3001JAK\/STAT\u53d7\u5bb9\u4f53\u30ad\u30ca\u30fc\u30bc\u3092\u4ecb\u3057\u3066\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3057\u3066\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u523a\u6fc0\u907a\u4f1d\u5b50\uff08ISG\uff09\u3092\u751f\u6210\u3057\u307e\u3059\u3002<\/p>\n<p>\u8457\u8005\u3089\u306f\u3001SARS-CoV-2 \u975e\u69cb\u9020\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bNSP1 \u3068 NSP13\u304c\u3001IFN\u5fdc\u7b54\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3068NF-kB\u6d3b\u6027\u5316\u3092\u5236\u9650\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u3001NSP1 \u306f\u3001\u767a\u751f\u671f\u306e\u5bbf\u4e3b\u7ffb\u8a33\u3092\u963b\u5bb3\u3057\u3001NSP13\u306fTBK1\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001TBK1\u3092\u4ecb\u3057\u305fIFN\u6d3b\u6027\u5316\u3092\u30d6\u30ed\u30c3\u30af\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/NF-kB-promoter_IFN-\u03b2-promoter_ISRE-promoter_NSP1_NSP13.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/NF-kB-promoter_IFN-\u03b2-promoter_ISRE-promoter_NSP1_NSP13-300x120.png\" alt=\"\" width=\"300\" height=\"120\" class=\"alignleft size-medium wp-image-4442\" 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href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2-%e3%81%ae%e9%9d%9e%e6%a7%8b%e9%80%a0%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%a7%e3%81%82%e3%82%8b-nsp1-%e3%81%a8-nsp13-%e3%81%8c%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%95\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-4380","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"University of Pennsylvania Perelman School of Medicine,\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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