{"id":4376,"date":"2021-06-27T13:25:03","date_gmt":"2021-06-27T04:25:03","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4367"},"modified":"2021-06-27T13:28:01","modified_gmt":"2021-06-27T04:28:01","slug":"roles-of-%ce%b4h69-v70-mutation-seen-in-multiple-independent-lineages-of-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/roles-of-%ce%b4h69-v70-mutation-seen-in-multiple-independent-lineages-of-sars-cov-2\/","title":{"rendered":"Roles of \u0394H69\/V70 mutation seen in multiple independent lineages of SARS-CoV-2\u00a0"},"content":{"rendered":"<p>A group from University of Cambridge, UK, etc. has reported on roles of \u0394H69\/V70 mutation seen in multiple independent lineages of SARS-CoV-2.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34166617\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34166617\/<\/a><\/p>\n<p>There was no overall change in susceptibility to serum neutralization for \u0394H69\/V70 relative to the WT, suggesting that \u0394H69\/V70 does not represent an important antibody escape mechanism. <\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/\u0394H69-V70_neutralisation-titer.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/\u0394H69-V70_neutralisation-titer.png\" alt=\"\" width=\"265\" height=\"259\" class=\"alignleft size-full wp-image-4368\" \/><\/a><\/p>\n<p>Western blotting for S2 spike indicated a higher amount of cleaved spike in \u0394H69\/V70 bearing virions and in the HEK293T producer cell lysates.\u3000<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/\u039469-V70_cleavage-rate.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/\u039469-V70_cleavage-rate-300x198.png\" alt=\"\" width=\"300\" height=\"198\" class=\"alignleft size-medium wp-image-4370\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/\u039469-V70_cleavage-rate-300x198.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/\u039469-V70_cleavage-rate.png 451w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>As a conclusion, it was found that \u0394H69\/V70 itself is not an antibody evasion mechanism, but increases infectivity associated with enhanced incorporation of cleaved spike into virions.<br \/>\n\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from University of Cambridge, UK, etc. has reported on roles of \u0394H69\/V70 mutation seen in multiple ind<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/roles-of-%ce%b4h69-v70-mutation-seen-in-multiple-independent-lineages-of-sars-cov-2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-4376","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4376"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4376\/revisions"}],"predecessor-version":[{"id":4377,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4376\/revisions\/4377"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}