{"id":4349,"date":"2021-06-27T08:42:49","date_gmt":"2021-06-26T23:42:49","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4349"},"modified":"2021-07-21T23:00:57","modified_gmt":"2021-07-21T14:00:57","slug":"hla-i%e3%81%a8hla-ii%e3%81%ab%e6%8a%97%e5%8e%9f%e6%8f%90%e7%a4%ba%e3%81%95%e3%82%8c%e3%82%8bsars-cov-2%e3%81%ae%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/hla-i%e3%81%a8hla-ii%e3%81%ab%e6%8a%97%e5%8e%9f%e6%8f%90%e7%a4%ba%e3%81%95%e3%82%8c%e3%82%8bsars-cov-2%e3%81%ae%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3\/","title":{"rendered":"HLA-I\u3068HLA-II\u306b\u6297\u539f\u63d0\u793a\u3055\u308c\u308bSARS-CoV-2\u306e\u30da\u30d7\u30c1\u30c9\u30c9\u30e1\u30a4\u30f3"},"content":{"rendered":"<p>Weizmann Institute of Science, Rehovot, Israel\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u611f\u67d3\u306b\u7531\u6765\u3059\u308bHLA-I \u3068 HLA-II \u6297\u539f\u63d0\u793a\u30da\u30d7\u30c1\u30c9\u306b\u95a2\u3057\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34166618\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34166618\/<\/a><\/p>\n<p>ACE2\u3092\u767a\u73fe\u3059\u308bHEK293T\u7d30\u80de\u3001IHW01070\u7d30\u80de\u3001\u304a\u3088\u3073Calu-3\u7d30\u80de\u3092SARS-CoV-2\u3067\u611f\u67d3\u3055\u305b\u307e\u3057\u305f\u3002HLA-I\u3068HLA-II\u306b\u6297\u539f\u63d0\u793a\u3055\u308c\u308b\u6297\u539f\u3092\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3059\u308b\u305f\u3081\u306b\u3001HLA peptidomics\u3092\u4f7f\u7528\u3057\u3001\u5b9f\u9a13\u306f\u4e09\u56de\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u56e0\u307f\u306b\u3001\u3054\u5b58\u3058\u306e\u3088\u3046\u306b\u3001HLA-I\u306f\u5185\u56e0\u6027\u30da\u30d7\u30c1\u30c9\u6297\u539f\u3092\u3001HLA-II\u306f\u5916\u56e0\u6027\u30da\u30d7\u30c1\u30c9\u6297\u539f\u3092\u63d0\u793a\u3057\u307e\u3059\u3002<\/p>\n<p><strong>10\u500b\u306eHLA-I\u30da\u30d7\u30c1\u30c9<\/strong>\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n<strong>2\u500b\u306fspike protein\u304b\u3089<\/strong>, NEVAKNLNESL and TGSNVFQTR\u3001<br \/>\n<strong>2\u500b\u306fnsp3\u304b\u3089<\/strong>, STTTNIVTR and YYTSNPTTF\u3001<br \/>\n<strong>1\u500b\u304cORF3\u304b\u3089<\/strong>, FTIGTVTLK\u3001<br \/>\n<strong>1\u500b\u304cnsp1\u304b\u3089<\/strong>, HSSGVTREL\u3001<br \/>\n<strong>4\u500b\u304cnucleocapsid\u304b\u3089<\/strong>, APRITFGGP, RITFGGPSD, NAPRITFGGP &amp; ITFGGPSDSTGSNQNGER\u3002<\/p>\n<p><strong>25\u500b\u306e\u7573\u307f\u8fbc\u307e\u308c\u305f\u30da\u30d7\u30c1\u30c9\u30bb\u30c3\u30c8\u304cHLA-II\u6297\u539f\u3068\u3057\u3066membrane\u304b\u3089 <\/strong>\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u60c5\u5831\u306f\u30ef\u30af\u30c1\u30f3\u958b\u767a\u306b\u5f79\u306b\u305f\u3061\u305d\u3046\u3067\u3059\u306d\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HLA-II_membrane.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HLA-II_membrane-300x205.png\" alt=\"\" width=\"300\" height=\"205\" class=\"alignleft size-medium wp-image-4351\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HLA-II_membrane-300x205.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HLA-II_membrane.png 600w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Weizmann Institute of Science, Rehovot, Israel\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u611f\u67d3\u306b\u7531\u6765\u3059\u308bHLA-I \u3068 HLA-II \u6297\u539f\u63d0\u793a\u30da\u30d7\u30c1\u30c9\u306b\u95a2\u3057\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 htt<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/hla-i%e3%81%a8hla-ii%e3%81%ab%e6%8a%97%e5%8e%9f%e6%8f%90%e7%a4%ba%e3%81%95%e3%82%8c%e3%82%8bsars-cov-2%e3%81%ae%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-4349","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Weizmann Institute of Science, Rehovot, Israel\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001S\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/hla-i%e3%81%a8hla-ii%e3%81%ab%e6%8a%97%e5%8e%9f%e6%8f%90%e7%a4%ba%e3%81%95%e3%82%8c%e3%82%8bsars-cov-2%e3%81%ae%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3\/\" \/>\n\t<meta name=\"generator\" 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