{"id":4329,"date":"2021-06-26T15:19:47","date_gmt":"2021-06-26T06:19:47","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4329"},"modified":"2021-07-21T23:01:20","modified_gmt":"2021-07-21T14:01:20","slug":"fc%ce%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%82%92%e4%bb%8b%e3%81%97%e3%81%9f%e3%82%a8%e3%83%95%e3%82%a7%e3%82%af%e3%82%bf%e3%83%bc%e5%8a%b9%e6%9e%9c%e3%81%a8%e6%8a%97%e4%bd%93%e4%be%9d%e5%ad%98%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/fc%ce%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%82%92%e4%bb%8b%e3%81%97%e3%81%9f%e3%82%a8%e3%83%95%e3%82%a7%e3%82%af%e3%82%bf%e3%83%bc%e5%8a%b9%e6%9e%9c%e3%81%a8%e6%8a%97%e4%bd%93%e4%be%9d%e5%ad%98%e6%80%a7\/","title":{"rendered":"Fc\u03b3\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u52b9\u679c\u3068\u6297\u4f53\u4f9d\u5b58\u6027\u611f\u67d3\u5897\u5f37 (ADE)\uff1aSARS-CoV-2\u306e\u6cbb\u7642\u7528\u6297\u4f53\u306b\u95a2\u3057\u3066"},"content":{"rendered":"<p>Biological Defense Program, DSO National Laboratories, Singapore\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u4e2d\u548c\u6297\u4f53\u306eFc\u3092\u4ecb\u3057\u305f\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0253487\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0253487<\/a><\/p>\n<p>\u6297\u4f53\u4f9d\u5b58\u6027\u611f\u67d3\u5897\u5f37 (ADE)\u306f\u3001\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6297SARS-CoV-2\u6297\u4f53\u3092\u4f7f\u7528\u3059\u308b\u5834\u5408\u306e\u5927\u304d\u306a\u61f8\u5ff5\u3068\u3057\u3066\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002ADE\u306f\u3001Fc\u03b3\u53d7\u5bb9\u4f53\u304c\u95a2\u4e0e\u3057\u3066\u3001\u98df\u7d30\u80de\u306b\u304a\u3051\u308b\u611f\u67d3\u3092\u5897\u5f37\u3057\u305f\u5834\u5408\u306b\u8d77\u3053\u308a\u307e\u3059\u3002ADE\u306e\u53ef\u80fd\u6027\u3092\u6392\u9664\u3059\u308b\u305f\u3081\u306b\u3001Fc\u03b3\u53d7\u5bb9\u4f53\u304c\u95a2\u4fc2\u3057\u306a\u3044\u4f8b\u3048\u3070IgG4\u30a2\u30a4\u30bd\u30bf\u30a4\u30d7\u3092\u4f7f\u7528\u3057\u305f\u308a\u3001Fc\u03b3R-null LALA \u5909\u7570\u3092\u4eba\u5de5\u7684\u306b\u5c0e\u5165\u3059\u308b\u3068\u3044\u3046\u3088\u3046\u306a\u624b\u6cd5\u304c\u3068\u3089\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u308c\u3089\u306e\u624b\u6cd5\u306f\u9006\u52b9\u679c\u3092\u3082\u305f\u3089\u3057\u3001\u6297\u4f53\u306e\u6301\u3064\u80fd\u529b\u3092\u4e0b\u652f\u3048\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u30d1\u30b9\u3001\u4f8b\u3048\u3070Fc\u03b3\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305fADCC\u52b9\u679c\u3001\u3092\u6bba\u3057\u3066\u3057\u307e\u3046\u306f\u305a\u3067\u3059\u3002\u3053\u306e\u554f\u984c\u306b\u7b54\u3048\u308b\u305f\u3081\u306b\u3001\u8457\u8005\u3089\u306fSARS-CoV-2\u56de\u5fa9\u671f\u60a3\u8005\u304b\u3089RBD\u306b\u7d50\u5408\u3059\u308b\u4e2d\u548c\u6297\u4f53IgG1\u3092\u62bd\u51fa\u3057\uff08SC31\u3068\u547d\u540d\uff09\u3001\u305d\u306e\u6cbb\u7642\u52b9\u679c\u3092\u305d\u306eLALA\u5909\u7570\u4f53\u3068\u6bd4\u8f03\u3059\u308b\u5b9f\u9a13\u3092\u884c\u3044\u3001SC31\u306fADE\u3092\u8d77\u3053\u3059\u3053\u3068\u306a\u304f\u3001Fc\u03b3\u53d7\u5bb9\u4f53\u304c\u304b\u304b\u308f\u308bINF-\u03b3\u3089\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u5fdc\u7b54\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Fc-mediated-effector-functions.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Fc-mediated-effector-functions-300x81.png\" alt=\"\" width=\"600\" height=\"161\" class=\"alignleft size-medium wp-image-4334\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Fc-mediated-effector-functions-300x81.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Fc-mediated-effector-functions-600x161.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Fc-mediated-effector-functions-768x207.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Fc-mediated-effector-functions.png 903w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p>SC31\u306e\u6cbb\u7642\u52b9\u679c\u306b\u304a\u3051\u308bFc\u03b3\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u52b9\u679c\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001SC31\u3068\u305d\u306eLALA\u5909\u7570\u4f53\u306e\u6bd4\u8f03\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002 Fc\u03b3RIIIa ADCC\u30b7\u30b0\u30ca\u30eb\u30d1\u30b9\u306e\u4e0a\u6d41\u306e\u6d3b\u6027\u5316\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001ADCC reporter assay\u3092\u7d44\u307f\u8fbc\u3093\u3060Fc\u03b3RIIIa\u3092\u767a\u73fe\u3059\u308bJurkat reporter \u7d30\u80de\u682a\u3092\u4f7f\u7528\u3057\u3001SARS-CoV-2 Spike\u3092\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u3057\u305fHEK293T\u682a\u3092\u5171\u57f9\u990a\u3057\u3066\u3001\u86cd\u5149\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002SC31\u306eLALA \u5909\u7570\u4f53\u3068\u306f\u7570\u306a\u308a\u3001SC31\u306b\u304a\u3044\u3066\u306f\u3001\u30c9\u30fc\u30ba\u4f9d\u5b58\u6027\u3092\u6301\u3061\u306a\u304c\u3089ADCC\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/SC31-induces-ADCC.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/SC31-induces-ADCC-292x300.png\" alt=\"\" width=\"292\" height=\"300\" class=\"alignleft size-medium wp-image-4333\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/SC31-induces-ADCC-292x300.png 292w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/SC31-induces-ADCC.png 493w\" sizes=\"auto, (max-width: 292px) 100vw, 292px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biological Defense Program, DSO National Laboratories, Singapore\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u4e2d\u548c\u6297\u4f53\u306eFc\u3092\u4ecb\u3057\u305f\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/fc%ce%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%82%92%e4%bb%8b%e3%81%97%e3%81%9f%e3%82%a8%e3%83%95%e3%82%a7%e3%82%af%e3%82%bf%e3%83%bc%e5%8a%b9%e6%9e%9c%e3%81%a8%e6%8a%97%e4%bd%93%e4%be%9d%e5%ad%98%e6%80%a7\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-4329","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4329","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4329"}],"version-history":[{"count":12,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4329\/revisions"}],"predecessor-version":[{"id":5067,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4329\/revisions\/5067"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4329"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4329"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}