{"id":4283,"date":"2021-06-21T14:58:12","date_gmt":"2021-06-21T05:58:12","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4279"},"modified":"2021-06-21T15:01:34","modified_gmt":"2021-06-21T06:01:34","slug":"as-a-therapeutic-drug-for-covid-19-a-novel-class-of-small-molecule-ketobenzothiazole-tmprss2-inhibitor-was-discovered","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/as-a-therapeutic-drug-for-covid-19-a-novel-class-of-small-molecule-ketobenzothiazole-tmprss2-inhibitor-was-discovered\/","title":{"rendered":"As a therapeutic drug for COVID-19, \u00a0a novel class of small molecule ketobenzothiazole TMPRSS2 inhibitor was discovered"},"content":{"rendered":"<p>A group from Washington University School of Medicine, Saint Louis, Missouri, United States has discovered a novel class of small molecule ketobenzothiazole TMPRSS2 inhibitors with significantly improved activity over existing irreversible inhibitors Camostat and Nafamostat. Lead compound MM3122 has an IC<sub>50<\/sub> of 340 pM against recombinant full-length TMPRSS2 protein, an EC<sub>50<\/sub> of 430 pM in blocking host cell entry into Calu-3 human lung epithelial cells.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8204910\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8204910\/<\/a><\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor-300x197.png\" alt=\"\" width=\"300\" height=\"197\" class=\"alignleft size-medium wp-image-4280\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor-300x197.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor-600x395.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor.png 655w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Washington University School of Medicine, Saint Louis, Missouri, United States has discovered a n<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/as-a-therapeutic-drug-for-covid-19-a-novel-class-of-small-molecule-ketobenzothiazole-tmprss2-inhibitor-was-discovered\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-4283","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"A group from Washington University School of Medicine,\" \/>\n\t<meta name=\"robots\" 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