{"id":4279,"date":"2021-06-21T14:58:12","date_gmt":"2021-06-21T05:58:12","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4279"},"modified":"2021-06-21T14:58:12","modified_gmt":"2021-06-21T05:58:12","slug":"covid-19%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a8%e3%81%97%e3%81%a6%e3%80%81tmprss2%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e4%bd%8e%e5%88%86%e5%ad%90%e5%8c%96%e5%90%88%e7%89%a9-keto","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/covid-19%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a8%e3%81%97%e3%81%a6%e3%80%81tmprss2%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e4%bd%8e%e5%88%86%e5%ad%90%e5%8c%96%e5%90%88%e7%89%a9-keto\/","title":{"rendered":"COVID-19\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3001TMPRSS2\u963b\u5bb3\u5264\u3068\u3057\u3066\u306e\u4f4e\u5206\u5b50\u5316\u5408\u7269 ketobenzothiazole \u304c\u6709\u529b\u306a\u5019\u88dc\u306b\u6319\u304c\u308b"},"content":{"rendered":"<p>Washington University School of Medicine, Saint Louis, United States\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u65e2\u5b58\u306eCamostat and Nafamostat\u306b\u5bfe\u3057\u3066\u3082\u975e\u5e38\u306b\u512a\u308c\u305f\u6d3b\u6027\u3092\u793a\u3059\u77e5\u5206\u5b50\u306eTMPRSS2\u963b\u5bb3\u5264 ketobenzothiazole\u3092\u767a\u898b\u3057\u305f\u3002\u305d\u306e\u30ea\u30fc\u30c9\u304c\u8c6a\u7269\u3067\u3042\u308b MM3122 \u306f\u3001recombinant full-length TMPRSS2\u306b\u5bfe\u3057\u3066\u3001IC<sub>50<\/sub> = 340 pM \u3068\u3044\u3046\u963b\u5bb3\u52b9\u679c\u3092\u793a\u3057\u3001\u30d2\u30c8\u306eCalu-3\u80ba\u4e0a\u76ae\u7d30\u80de\u3078\u306eSARS-CoV-2\u611f\u67d3\u306b\u5bfe\u3057\u3066\u3082EC<sub>50<\/sub> = 430 pM \u3068\u3044\u3046\u963b\u5bb3\u52b9\u679c\u3092\u793a\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8204910\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8204910\/<\/a><\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor-300x197.png\" alt=\"\" width=\"300\" height=\"197\" class=\"alignleft size-medium wp-image-4280\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor-300x197.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor-600x395.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/TMPRSS2-inhibitor.png 655w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Washington University School of Medicine, Saint Louis, United States\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u65e2\u5b58\u306eCamostat and Nafamostat\u306b\u5bfe\u3057\u3066\u3082\u975e\u5e38\u306b<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/covid-19%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a8%e3%81%97%e3%81%a6%e3%80%81tmprss2%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e4%bd%8e%e5%88%86%e5%ad%90%e5%8c%96%e5%90%88%e7%89%a9-keto\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-4279","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4279"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4279\/revisions"}],"predecessor-version":[{"id":4282,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4279\/revisions\/4282"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}