{"id":4256,"date":"2021-06-19T11:59:31","date_gmt":"2021-06-19T02:59:31","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4248"},"modified":"2021-06-19T12:01:54","modified_gmt":"2021-06-19T03:01:54","slug":"whether-hiv-antibodies-could-neutralize-sars-cov-2-or-not","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/whether-hiv-antibodies-could-neutralize-sars-cov-2-or-not\/","title":{"rendered":"Whether HIV antibodies could neutralize SARS-CoV-2 or not\u00a0"},"content":{"rendered":"

A group from University of British Columbia, Canada has reported whether HIV antibodies could neutralize SARS-CoV-2 or not.
\nhttps:\/\/www.nature.com\/articles\/s41598-021-91746-7<\/a><\/p>\n

Cross-reactive interactions of three HIV antibodies (2G12, PGT128, PGT126) in the presence of methyl \u03b1-d-mannopyranoside, a stabilized mannose analogue, were evaluated using an ELISA assay. Disruption of cross-reactivity was observed for all these antibodies with increasing concentrations of methyl \u03b1-d-mannopyranoside, demonstrating that the binding of these antibodies to SARS-CoV-2 were via glycan sensitivity of these interactions.<\/p>\n

\"\"<\/a><\/p>\n

HEK293-T cells stably overexpressing ACE-2 were incubated with SARS-CoV-2 S pseudo-typed virus harbouring a luciferase reporter gene, in the presence of serial dilutions of three HIV antibodies. Luciferase activities in cellular lysates were determined 48 h post-infection (RLU: relative luciferase units). However, no neutralization capabilities were detected for these antibodies over a wide range of concentrations, while VH-FC ab8 demonstrated potent neutralization, a positive control antibody VH-FC ab8 which targets the SARS-CoV-2 RBD.<\/p>\n

\"\"<\/a><\/p>\n

But, the blog admin thinks that the infection to immune cells (i.e., macrophages) expressing C-type lectins might be neutralized by these HIV antibodies?\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from University of British Columbia, Canada has reported whether HIV antibodies could neutralize SARS-<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-4256","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4256"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4256\/revisions"}],"predecessor-version":[{"id":4257,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4256\/revisions\/4257"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4256"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}