{"id":4248,"date":"2021-06-19T11:59:31","date_gmt":"2021-06-19T02:59:31","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4248"},"modified":"2021-07-21T23:03:05","modified_gmt":"2021-07-21T14:03:05","slug":"hiv%e3%81%ae%e6%8a%97%e4%bd%93%e3%81%afsars-cov-2%e3%81%ae%e7%b3%96%e9%8e%96%e6%8a%97%e5%8e%9f%e3%81%ab%e7%b5%90%e5%90%88%e3%81%99%e3%82%8b%e3%81%8c%e3%80%81%e4%b8%ad%e5%92%8c%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/hiv%e3%81%ae%e6%8a%97%e4%bd%93%e3%81%afsars-cov-2%e3%81%ae%e7%b3%96%e9%8e%96%e6%8a%97%e5%8e%9f%e3%81%ab%e7%b5%90%e5%90%88%e3%81%99%e3%82%8b%e3%81%8c%e3%80%81%e4%b8%ad%e5%92%8c%e3%81%99%e3%82%8b\/","title":{"rendered":"HIV\u306e\u6297\u4f53\u306fSARS-CoV-2\u306e\u7cd6\u9396\u6297\u539f\u306b\u7d50\u5408\u3059\u308b\u304c\u3001\u4e2d\u548c\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044"},"content":{"rendered":"<p>University of British Columbia, Canada\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001HIV\u306e\u6297\u4f53\u304cSARS-CoV-2\u3092\u4e2d\u548c\u5316\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-91746-7\">https:\/\/www.nature.com\/articles\/s41598-021-91746-7<\/a><\/p>\n<p>HIV\u306e\u6297\u4f533\u7a2e\uff082G12, PGT128, PGT126\uff09\u306eSARS-CoV-2\u3078\u306e\u7d50\u5408\u6027\u3092methyl \u03b1-d-mannopyranoside\uff08\u5b89\u5b9a\u5316\u3055\u308c\u305fmannose\u30a2\u30ca\u30ed\u30b0\uff09\u5b58\u5728\u4e0b\u3067ELISA\u30a2\u30c3\u30bb\u30a4\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002methyl \u03b1-d-mannopyranoside\u3000\u306e\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u3053\u308c\u3089\u6297\u4f53\u306e\u4ea4\u5dee\u53cd\u5fdc\u6027\u304c\u963b\u5bb3\u3055\u308c\u3001\u3053\u308c\u30893\u7a2e\u306eHIV\u6297\u4f53\u306fSARS-CoV-2\u306b\u5bfe\u3057\u3066\u7cd6\u9396\u3092\u4ecb\u3057\u3066\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2-300x181.png\" alt=\"\" width=\"300\" height=\"181\" class=\"alignleft size-medium wp-image-4250\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2-300x181.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2-600x361.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2.png 714w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>luciferase reporter gene\u3092\u5c0e\u5165\u3057\u305fSARS-CoV-2\u7591\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u3001ACE-2\u3092\u904e\u5270\u767a\u73fe\u3057\u305fHEK293-T \u7d30\u80de\u3078\u306e\u611f\u67d3\u963b\u5bb3\u5b9f\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u611f\u67d348\u6642\u9593\u5f8c\u306b\u3001\u7d30\u80de\u30e9\u30a4\u30bb\u30fc\u30c8\u4e2d\u306eLuciferase\u767a\u5149\u3092\u6e2c\u5b9a\u3057\u3066\u3044\u307e\u3059\uff08RLU: relative luciferase units\uff09\u3002 \u3053\u308c\u30893\u7a2e\u306eHIV\u6297\u4f53\u306e\u5834\u5408\u306b\u306f\u3001\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5e83\u3044\u6fc3\u5ea6\u7bc4\u56f2\u306b\u6e21\u3063\u3066\u4e2d\u548c\u6d3b\u6027\u306f\u5168\u304f\u898b\u53d7\u3051\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001SARS-CoV-2 RBD\u3092\u30a8\u30d4\u30c8\u30fc\u30d7\u3068\u3059\u308bVH-FC ab8\u6297\u4f53\u306e\u5834\u5408\u306b\u306f\u3001\u4e2d\u548c\u6d3b\u6027\u3092\u793a\u3059\u304d\u308c\u3044\u306a\u963b\u5bb3\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2_neutralization.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2_neutralization-300x119.png\" alt=\"\" width=\"300\" height=\"119\" class=\"alignleft size-medium wp-image-4251\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2_neutralization-300x119.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2_neutralization-600x238.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/HIV-antibodies_SARS-CoV-2_neutralization.png 710w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u3057\u304b\u3057\u3001\u30d6\u30ed\u30b0\u8457\u8005\u304c\u601d\u3046\u306b\u3001C-\u578b\u30ec\u30af\u30c1\u30f3\u3092\u767a\u73fe\u3059\u308b\u514d\u75ab\u7d30\u80de\uff08\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\uff09\u3078\u306e\u611f\u67d3\u306b\u5bfe\u3057\u3066\u306f\u3001\u3053\u308c\u3089\u306eHIV\u6297\u4f53\u3067\u3082\u4e2d\u548c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of British Columbia, Canada\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001HIV\u306e\u6297\u4f53\u304cSARS-CoV-2\u3092\u4e2d\u548c\u5316\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.nature.com\/a<\/p><\/div>\n<div class=\"blog-btn\"><a 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