{"id":4231,"date":"2021-06-17T11:37:43","date_gmt":"2021-06-17T02:37:43","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4225"},"modified":"2021-06-17T11:57:42","modified_gmt":"2021-06-17T02:57:42","slug":"p-cymene-could-be-an-antiviral-drug-for-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/p-cymene-could-be-an-antiviral-drug-for-sars-cov-2\/","title":{"rendered":"P-cymene could be an antiviral drug for SARS-CoV-2\u00a0"},"content":{"rendered":"<p>A group from University of Crete, Greece, has reported that p-cymene could be an antiviral drug for SARS-CoV-2.<br \/>\n<a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.798\">https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.798<\/a><\/p>\n<p>Treatment of SARS-CoV-2 infected Vero cells with variable concentrations of p-cymene resulted in a significant decrease of plaque formation and viral titer in the culture supernatants (up to 90%, verified by Q-PCR), at concentrations ranging from 0.0125 to 200 \u03bcg\/ml, after 2 days of incubation. Up to 95% reduced titer was also observed during pre-treatment of Vero cells, by Q-PCR, prior to infection with SARS-CoV-2. The IC<sub>50<\/sub> during co-treatment was 74.5 \u03bcg\/ml, while pre-treatment IC50 was reduced to 57 \u03bcg\/ml. Importantly, p-cymene at concentrations <100 \u03bcg\/ml does not impair cell viability.\n\nMolecular dynamics simulations of SARS-CoV-2 N protein complex with Importin A, in the absence or the presence of p-cymene, revealed that p-cymene is able to destabilize the nucleocapsid\u2013importin complex, resulting in inhibition of its nuclear translocation.\n\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/p-cymene_COVID-19.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/p-cymene_COVID-19-300x231.png\" alt=\"\" width=\"300\" height=\"231\" class=\"alignleft size-medium wp-image-4226\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/p-cymene_COVID-19-300x231.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/p-cymene_COVID-19.png 501w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from University of Crete, Greece, has reported that p-cymene could be an antiviral drug for SARS-CoV-2<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/p-cymene-could-be-an-antiviral-drug-for-sars-cov-2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-4231","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4231"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4231\/revisions"}],"predecessor-version":[{"id":4234,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4231\/revisions\/4234"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}