{"id":4208,"date":"2021-06-15T14:52:58","date_gmt":"2021-06-15T05:52:58","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4204"},"modified":"2021-06-15T14:55:25","modified_gmt":"2021-06-15T05:55:25","slug":"detailed-binding-characteristics-of-stl-pna-and-jacalin-to-o-galnac","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/detailed-binding-characteristics-of-stl-pna-and-jacalin-to-o-galnac\/","title":{"rendered":"Detailed binding characteristics of STL, PNA, and Jacalin to O-GalNAc"},"content":{"rendered":"<p>A group from Georgia State University, etc. has reported detailed binding characteristics of STL, PNA, and Jacalin to O-GalNAc with using chemoenzymatic modular assembly of O-GalNAc glycans.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-23428-x\">https:\/\/www.nature.com\/articles\/s41467-021-23428-x<\/a><\/p>\n<p>STL showed moderate binding to core 2 and 6 glycans presenting a terminal LacNAc motif (with\/without further modifications) but not to core 1 and 3 structures.<br \/>\nPNA selectively bound to T antigen and core 2 glycans with an unmodified \u03b21-3Gal branch.<br \/>\nJacalin bound strongly to all core 3 and nearly all core 1 glycans (devoid of \u03b12-6 sialylation) at the same level of the Tn antigen, but did not bind to any core 2, 4, or 6 structures.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc-300x202.png\" alt=\"\" width=\"300\" height=\"202\" class=\"alignleft size-medium wp-image-4205\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc-300x202.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc-600x404.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc-1024x689.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc-768x517.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc-1536x1033.png 1536w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc-272x182.png 272w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/STL_PNA_Jacalin_to_O-GalNAc.png 1976w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Georgia State University, etc. has reported detailed binding characteristics of STL, PNA, and Jac<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/detailed-binding-characteristics-of-stl-pna-and-jacalin-to-o-galnac\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-4208","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4208","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4208"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4208\/revisions"}],"predecessor-version":[{"id":4209,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4208\/revisions\/4209"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4208"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4208"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}