{"id":4150,"date":"2021-06-13T10:46:41","date_gmt":"2021-06-13T01:46:41","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4150"},"modified":"2021-06-13T10:57:42","modified_gmt":"2021-06-13T01:57:42","slug":"%e3%82%a2%e3%83%97%e3%82%bf%e3%83%9e%e3%83%bc%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6%e7%b3%96%e9%8e%96%e3%81%a8%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e6%a7%8b%e9%80%a0%e3%82%92%e4%b8%a1%e6%96%b9%e5%90%8c","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%82%a2%e3%83%97%e3%82%bf%e3%83%9e%e3%83%bc%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6%e7%b3%96%e9%8e%96%e3%81%a8%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e6%a7%8b%e9%80%a0%e3%82%92%e4%b8%a1%e6%96%b9%e5%90%8c\/","title":{"rendered":"\u30a2\u30d7\u30bf\u30de\u30fc\u3092\u7528\u3044\u3066\u7cd6\u9396\u3068\u30da\u30d7\u30c1\u30c9\u69cb\u9020\u3092\u4e21\u65b9\u540c\u6642\u306b\u8a8d\u8b58\u3055\u305b\u308b\uff1a\u524d\u7acb\u817a\u764c\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bPSA\u3092\u30e2\u30c7\u30eb\u3068\u3057\u3066"},"content":{"rendered":"<p>Universidad de Oviedo, Spain\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001human prostate specific antigen (hPSA)\u306e\u7cd6\u9396\u3068\u305d\u306e\u30da\u30d7\u30c1\u30c9\u69cb\u9020\u3092\u4e21\u65b9\u540c\u6642\u306b\u8a8d\u8b58\u3067\u304d\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u3092SELEX\u306b\u3066\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34094206\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34094206\/<\/a><\/p>\n<p>hPSA\u306e\u7cd6\u9396\u3068\u30da\u30d7\u30c1\u30c9\u69cb\u9020\u3092\u4e21\u65b9\u8a8d\u8b58\u3055\u305b\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306b\u3001\u03b11-6 core-fucose\u306b\u7279\u7570\u6027\u3092\u6709\u3059\u308bPhoSL\u30ec\u30af\u30c1\u30f3\u3092\u7cd6\u9396\u4fee\u98fe\u30b5\u30a4\u30c8\u306b\u7279\u7570\u7684\u306a\u30a2\u30d7\u30bf\u30de\u30fc\u3092\u5f15\u3063\u304b\u3051\u308b\u78ba\u7387\u3092\u4e0a\u3052\u308b\u70ba\u306b\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>SELEX\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u78c1\u6c17\u30d3\u30fc\u30ba\uff08MPs\uff09\u306bhPSA\u6216\u3044\u306f\u7cd6\u9396\u3092\u6301\u305f\u306a\u3044recombinant PSA\u3092\u56fa\u5b9a\u5316\u3059\u308b\u3053\u3068\u304b\u3089\u59cb\u307e\u308a\u307e\u3059\u3002BSA\u3092\u30d6\u30ed\u30c3\u30ad\u30f3\u30b0\u6750\u3068\u3057\u3066\u4f7f\u7528\u3057\u3001BSA\u306b\u7d50\u5408\u3059\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u3092BSA-MPs\u3092\u7528\u3044\u3066\u9664\u53bb\u3057\u307e\u3059\u3002rPSA-MPs\u3092\u7528\u3044\u3066\u7cd6\u9396\u4fee\u98fe\u4f4d\u7f6e\u3068\u306f\u7570\u306a\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u9818\u57df\u306b\u7d50\u5408\u3059\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u3092\u9664\u53bb\u3057\u307e\u3059\u3002\u305d\u3057\u3066hPSA-MPs\u3092\u7528\u3044\u3066PSA\u306e\u7cd6\u9396\u306b\u7d50\u5408\u3059\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u30a8\u30f3\u30ea\u30c3\u30c1\u3057\u307e\u3059\u3002 <\/p>\n<p>\u3053\u306e\u5f8c\u3001\u3075\u305f\u3064\u306e\u30eb\u30fc\u30c8\u306b\u5206\u3051\u307e\u3059\u304c\u3001\u6226\u7565\uff21\u3067\u306f\u3001PhoSL\u3067\u30d6\u30ed\u30c3\u30ad\u30f3\u30b0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30d6\u30ed\u30c3\u30ad\u30f3\u30b0\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u5206\u5b50\u3092\u3088\u308a\u53b3\u683c\u306b\u9664\u53bb\u3059\u308b\u9078\u629e\u3092\u884c\u3044\u3001\u6226\u7565B\u3067\u306fPhoSL\u7d50\u5408\u30b5\u30a4\u30c8\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u5206\u5b50\u3092\u7af6\u5408\u7684\u306b\u30a8\u30eb\u30fc\u30b7\u30e7\u30f3\u3055\u305b\u307e\u3059\u3002\u6226\u7565A\u3067\u306f\u3001hPSA\u306b\u7d50\u5408\u3059\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u6e1b\u5c11\u3057\u307e\u3059\u304c\u3001PhoSL\u3092\u7528\u3044\u305f\u7af6\u5408\u7684\u306a\u30a8\u30eb\u30fc\u30b7\u30e7\u30f3\u306f\u3001hPSA\u306b\u7d50\u5408\u3059\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u3092\u5897\u3084\u3059\u3068\u3068\u3082\u306b\u305d\u306e\u7d50\u5408\u529b\u3092\u4e0a\u3052\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p>\u4e0b\u56f3\u306f\u3001\u5f97\u3089\u308c\u305f\u30a2\u30d7\u30bf\u30de\u30fc\uff08PSAG-1\uff09\u306e\u7d50\u5408\u7279\u7570\u6027\u3092\u793a\u3059\u3082\u306e\u3067\u3059\u304c\u3001\u3075\u305f\u3064\u306eCure fucose\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u3001lipocalin-2 (NGAL) \u3068 \u03b1-fetoprotein (AFP)\u304c\u53c2\u7167\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u524d\u7acb\u817a\u764c\u306b\u7279\u7570\u7684\u306a\u7cd6\u9396\u69cb\u9020\u3092\u3088\u308a\u7cbe\u5bc6\u306b\u8a8d\u8b58\u3067\u304d\u308b\u3053\u306e\u3088\u3046\u306a\u30a2\u30d7\u30bf\u30de\u30fc\u304c\u958b\u767a\u3067\u304d\u308c\u3070\u3001\u3053\u306e\u65b9\u6cd5\u306b\u671f\u5f85\u304c\u6301\u3066\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/aptomer_PSAG-1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/aptomer_PSAG-1-300x262.png\" alt=\"\" width=\"300\" height=\"262\" class=\"alignleft size-medium wp-image-4152\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/aptomer_PSAG-1-300x262.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/aptomer_PSAG-1.png 384w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Universidad de Oviedo, Spain\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001human prostate specific antigen (hPSA)\u306e\u7cd6\u9396\u3068\u305d\u306e\u30da\u30d7\u30c1\u30c9\u69cb\u9020\u3092\u4e21\u65b9\u540c\u6642\u306b\u8a8d\u8b58\u3067\u304d\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u3092SELEX\u306b\u3066\u958b<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%82%a2%e3%83%97%e3%82%bf%e3%83%9e%e3%83%bc%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6%e7%b3%96%e9%8e%96%e3%81%a8%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e6%a7%8b%e9%80%a0%e3%82%92%e4%b8%a1%e6%96%b9%e5%90%8c\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-4150","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Universidad de Oviedo, Spain\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001human prostate speci\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/%e3%82%a2%e3%83%97%e3%82%bf%e3%83%9e%e3%83%bc%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6%e7%b3%96%e9%8e%96%e3%81%a8%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e6%a7%8b%e9%80%a0%e3%82%92%e4%b8%a1%e6%96%b9%e5%90%8c\/\" \/>\n\t<meta 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