{"id":4145,"date":"2021-06-12T08:50:19","date_gmt":"2021-06-11T23:50:19","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4131"},"modified":"2021-06-12T08:54:37","modified_gmt":"2021-06-11T23:54:37","slug":"cell-to-cell-transmission-could-be-a-major-factor-in-sras-cov-2-spread%ef%bc%9aace2-is-not-so-important-in-this-case","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/cell-to-cell-transmission-could-be-a-major-factor-in-sras-cov-2-spread%ef%bc%9aace2-is-not-so-important-in-this-case\/","title":{"rendered":"Cell-to-cell transmission could be a major factor in SRAS-CoV-2 spread\uff1aACE2 is not so important in this case"},"content":{"rendered":"<p>A group from The Ohio State University, etc. has reported that cell-to-cell transmission could be a major factor in SRAS-CoV-2 infection spread.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8183005\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8183005\/<\/a><\/p>\n<p>ACE2 is the primary receptor of both SARS-CoV-2 and SARS-CoV, mediating viral entry into host cells. The virus infection through the binding between SARS-CoV-2 Spike and ACE2 increases linearly with increasing ACE2 expression on host cells as shown below for both SARS-CoV-2 and SARS-CoV. However, interestingly, with a relatively low dose of ACE2, SARS-CoV-2 cell-to-cell transmission reached ~70% of its maximal and started to decrease with increasing further as shown below. This pattern of SARS-CoV-2 cell-to-cell transmission was different from that of cell-free infection, suggesting that the cell-to-cell transmission happens independently from ACE2 mediated infection. <\/p>\n<p>Interestingly, it was shown that endosomal entry pathways were also involved in cell-to-cell transmission of SARS-CoV-2 and SARS-CoV. This is evidenced as shown below by the inhibitory effect of drugs that specifically target the endosomal entry pathway of these viruses, including the CatL inhibitor III, which blocks cleavage of the viral glycoprotein, as well as BafA1, which neutralizes endosomal pH.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/cell-to-cell_transmission.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/cell-to-cell_transmission-300x244.png\" alt=\"\" width=\"300\" height=\"244\" class=\"alignleft size-medium wp-image-4136\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/cell-to-cell_transmission-300x244.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/cell-to-cell_transmission-600x489.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/cell-to-cell_transmission-768x626.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/cell-to-cell_transmission.png 913w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from The Ohio State University, etc. has reported that cell-to-cell transmission could be a major fact<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/cell-to-cell-transmission-could-be-a-major-factor-in-sras-cov-2-spread%ef%bc%9aace2-is-not-so-important-in-this-case\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-4145","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4145"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4145\/revisions"}],"predecessor-version":[{"id":4147,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4145\/revisions\/4147"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}