{"id":4097,"date":"2021-06-09T10:42:02","date_gmt":"2021-06-09T01:42:02","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4097"},"modified":"2021-07-21T23:05:53","modified_gmt":"2021-07-21T14:05:53","slug":"human-surfactant-protein-d%e3%81%8c%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e5%ae%b3%e3%81%99","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/human-surfactant-protein-d%e3%81%8c%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e5%ae%b3%e3%81%99\/","title":{"rendered":"Human Surfactant Protein D\u304c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u611f\u67d3\u3092\u963b\u5bb3\u3059\u308b\u3089\u3057\u3044"},"content":{"rendered":"

National Cheng Kung University, Taiwan\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001human surfactant protein D \u304c\u3001SARS-CoV-2\u611f\u67d3\u306b\u5bfe\u3057\u3066\u611f\u67d3\u963b\u5bb3\u3068\u3044\u3046\u89b3\u70b9\u3067\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u52b9\u679c\u3092\u6709\u3059\u308b\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8161545\/<\/a><\/p>\n

Human surfactant protein D (SP-D) \u306f\u3001\u30b3\u30ec\u30af\u30c1\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308a\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u542b\u3093\u3060C-\u578b\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308a\u3001\u80ba\u306e\u6052\u5e38\u6027\u3084\u514d\u75ab\u306b\u304b\u304b\u308f\u308b\u80ba\u30b5\u30fc\u30d5\u30a1\u30af\u30bf\u30f3\u30c8\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002 \u3053\u306eSP-D\u306e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3067\u3042\u308b(rfhSP-D)\u304cSARS-CoV-2\u306b\u5bfe\u3059\u308b\u611f\u67d3\u963b\u5bb3\u52b9\u679c\u3092\u6301\u3064\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3059\u308b\u507d\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\u3092\u4f7f\u7528\u3057\u3066\u611f\u67d3\u5b9f\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002rfhSP-D \u306f\u3001SARS-CoV-2 S1 \u306b\u5bfe\u3057\u3066\u30c9\u30fc\u30ba\u4f9d\u5b58\u7684\u306b\u7d50\u5408\u3057\u3001\u3053\u306e\u7d50\u5408\u306fmaltose\u3084EDTA\u3067\u963b\u5bb3\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u306e\u5b9f\u9a13\u3067\u306f\u3001SARS-CoV-2 RBD\u304c\u306a\u3044\u5834\u5408\u306b\u306f\u3001rfhSP-D\u306f\u5168\u304f\u7d50\u5408\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

rfhSP-D \u3068 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d50\u5408\u304cEDTA \u3084 maltose \u306b\u3088\u3063\u3066\u963b\u5bb3\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001rfhSP-D \u304cSARS-CoV2 Spike\u306e\u7cd6\u9396\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u507d\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\u306e\u611f\u67d3\u52b9\u7387\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u30eb\u30b7\u30d5\u30a7\u30e9\u30fc\u30bc\u30fb\u30ec\u30dd\u30fc\u30bf\u30fc\u30fb\u30a2\u30c3\u30bb\u30a4\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002ACE2\u3092\u904e\u5270\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u907a\u4f1d\u5b50\u5c0e\u5165\u3055\u308c\u305fHEK293T\u306b\u5bfe\u3057\u3066SARS-CoV-2\u3092\u672a\u51e6\u7406\u3067\u611f\u67d3\u3055\u305b\u305f\u3068\u304d\u306e\u306b\u6bd4\u8f03\u3057\u3066\uff08\u3053\u308c\u30921 RLU\u3068\u3059\u308b\uff09\u3001rfhSP-D (5 or 10 \u00b5g\/ml) \u306e\u51e6\u7406\u3067\u30010.5 RLU\u306b\u86cd\u5149\u304c\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u9855\u8457\u306a\u86cd\u5149\u306e\u6e1b\u5c11\u306f\u3001rfhSP-D\u306e\u51e6\u7406\u304cSARS-CoV-2\u306e\u611f\u67d3\u3092\u963b\u5bb3\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u308c\u3089\u306e\u5b9f\u9a13\u7d50\u679c\u306f\u3001rfhSP-D \u306e SARS-CoV-2 \u611f\u67d3\u306b\u5bfe\u3059\u308b\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u52b9\u679c\u3092\u793a\u3059\u3082\u306e\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

National Cheng Kung University, Taiwan\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001human surfactant protein D \u304c\u3001SARS-CoV-2\u611f\u67d3\u306b\u5bfe\u3057\u3066\u611f\u67d3\u963b\u5bb3\u3068\u3044\u3046\u89b3\u70b9\u3067\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u52b9\u679c\u3092<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-4097","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4097"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4097\/revisions"}],"predecessor-version":[{"id":4101,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4097\/revisions\/4101"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}