{"id":4079,"date":"2021-06-08T06:08:03","date_gmt":"2021-06-07T21:08:03","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4079"},"modified":"2021-07-21T23:06:14","modified_gmt":"2021-07-21T14:06:14","slug":"ace2%e3%81%a8sars-cov-2-rbd%e3%81%ae%e7%b5%90%e5%90%88%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%ef%bc%88oligomannose%e3%81%8a%e3%82%88%e3%81%b3bi-antennary-complex-n-gly","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/ace2%e3%81%a8sars-cov-2-rbd%e3%81%ae%e7%b5%90%e5%90%88%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%ef%bc%88oligomannose%e3%81%8a%e3%82%88%e3%81%b3bi-antennary-complex-n-gly\/","title":{"rendered":"ACE2\u3068SARS-CoV-2 RBD\u306e\u7d50\u5408\u306b\u5bfe\u3059\u308b\u7cd6\u9396\u4fee\u98fe\uff08Oligomannose\u304a\u3088\u3073bi-antennary complex N-glycan)\u306e\u5f71\u97ff"},"content":{"rendered":"<p>Los Alamos National Laboratory\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306eRBD\u3068ACE2\u3068\u306e\u7d50\u5408\u6027\u306b\u5bfe\u3059\u308b\u7cd6\u9396\u306e\u5f71\u97ff\u3092\u5206\u5b50\u52d5\u529b\u5b66\u3092\u7528\u3044\u3066\u691c\u8a0e\u3057\u305f\u7d50\u679c\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.mdpi.com\/1999-4915\/13\/5\/927\">https:\/\/www.mdpi.com\/1999-4915\/13\/5\/927<\/a><\/p>\n<p>ACE2\u306b6\u500b\u306eOligomannose (MAN9\uff09\u304c Asn53, Asn90, Asn103, Asn322, Asn432, Asn546\u306e\u4f4d\u7f6e\u306b\u4fee\u98fe\u3055\u308c\u3001SARS-CoV-2\u306eRBD\u306bbi-antennary complex N-glyucan\uff08FA2\uff09\u304cAsn343\u306e\u4f4d\u7f6e\u306b\u4fee\u98fe\u3055\u308c\u3066\u3044\u308b\u3068\u3057\u305f\u5834\u5408\u3068\u3001\u3053\u308c\u3089\u3059\u3079\u3066\u306e\u7cd6\u9396\u4fee\u98fe\u4f4d\u7f6e\u304cbi-antennary complex N-glycan\u3067\u3042\u308b\u3068\u3057\u305f\u5834\u5408\u3092\u30e2\u30c7\u30eb\u3068\u3057\u3066\u7d50\u5408\u529b\u3092\u8a08\u7b97\u3057\u3066\u3044\u307e\u3059\u3002\u4e0b\u56f3\u3067\u306f\u3001MAN9\u306f\u8d64\u8272\u3067\u3001FA2\u306f\u9752\u8272\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u7d50\u679c\u3001ACE2\u306e\u7cd6\u9396\u4fee\u98fe\u304cMAN9\u3067\u3042\u308b\u5834\u5408\u306b\u306f\u3001\u7d50\u5408\u529b\u304c14.7%\u6e1b\u5c11\u3057\u3001\u305d\u308c\u304cFA2\u3067\u3042\u308b\u5834\u5408\u306b\u306f\u30019.1%\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/ACE2-RBD-binding-with-two-types-of-glycans.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/ACE2-RBD-binding-with-two-types-of-glycans-300x126.png\" alt=\"\" width=\"300\" height=\"126\" class=\"alignleft size-medium wp-image-4080\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/ACE2-RBD-binding-with-two-types-of-glycans-300x126.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/ACE2-RBD-binding-with-two-types-of-glycans-600x252.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/ACE2-RBD-binding-with-two-types-of-glycans.png 732w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>ACE2\u306e\u4fee\u98fe\u3092high mannose\u578b\u306b\u3057\u305f\u5834\u5408\u306f\u3001\u611f\u67d3\u529b\u304c\u82e5\u5e72\u4e0b\u304c\u308b\u3068\u3044\u3046\u5b9f\u9a13\u7d50\u679c\u304c\u3042\u308a\u3001\u77db\u76fe\u306f\u3057\u3066\u3044\u306a\u3044\u3088\u3046\u3067\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001N501Y\u5909\u7570\u3067\u3001\u4f55\u6545\u611f\u67d3\u529b\u304c\u4e0a\u304c\u308b\u304b\u306b\u3064\u3044\u3066\u3082\u8a08\u7b97\u3055\u308c\u3066\u304a\u308a\u3001\u82b3\u9999\u74b0\u306e\u03c0\u30fc\u03c0\u76f8\u4e92\u4f5c\u7528\u306e\u5f71\u97ff\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u70b9\u306b\u3064\u3044\u3066\u306f\u3001\u65e2\u306b\u904e\u53bb\u306e\u30d6\u30ed\u30b0\u8a18\u4e8b\u3067\u540c\u69d8\u306a\u7814\u7a76\u4f8b\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Los Alamos National Laboratory\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306eRBD\u3068ACE2\u3068\u306e\u7d50\u5408\u6027\u306b\u5bfe\u3059\u308b\u7cd6\u9396\u306e\u5f71\u97ff\u3092\u5206\u5b50\u52d5\u529b\u5b66\u3092\u7528\u3044\u3066\u691c\u8a0e\u3057\u305f\u7d50\u679c\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.m<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/ace2%e3%81%a8sars-cov-2-rbd%e3%81%ae%e7%b5%90%e5%90%88%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%ef%bc%88oligomannose%e3%81%8a%e3%82%88%e3%81%b3bi-antennary-complex-n-gly\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-4079","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Los Alamos National Laboratory\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306eRBD\u3068AC\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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