{"id":4071,"date":"2021-06-06T19:17:44","date_gmt":"2021-06-06T10:17:44","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4064"},"modified":"2021-06-07T06:31:33","modified_gmt":"2021-06-06T21:31:33","slug":"binding-specificity-of-siglecs-from-a-study-using-glycan-arrays","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/binding-specificity-of-siglecs-from-a-study-using-glycan-arrays\/","title":{"rendered":"N-glycan Binding specificity of Siglecs:  from a study using glycan arrays\u00a0"},"content":{"rendered":"<p>A group from Georgia State University, etc. has reported N-glycan binding specificity of siglecs using glycan arrays.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8116747\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8116747\/<\/a><\/p>\n<p>Siglec-3, -9, and -10 prefer the \u03b11-3 branching structure when Sia\u03b12-6Gal\u03b21-4GlcNAc terminal epitope serves as the binding ligand but prefer the opposite \u03b11-6 branching structure when Sia\u03b12-3Gal\u03b21-4GlcNAc epitope serves as the ligand. Interestingly, Siglec-10 exhibited strong affinity to Neu5Gc-containing N-glycans<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Siglec-binding-preference.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Siglec-binding-preference-300x206.png\" alt=\"\" width=\"300\" height=\"206\" class=\"alignleft size-medium wp-image-4075\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Siglec-binding-preference-300x206.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/Siglec-binding-preference.png 308w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Georgia State University, etc. has reported N-glycan binding specificity of siglecs using glycan <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/binding-specificity-of-siglecs-from-a-study-using-glycan-arrays\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-4071","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4071","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4071"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4071\/revisions"}],"predecessor-version":[{"id":4078,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4071\/revisions\/4078"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4071"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4071"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4071"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}