{"id":4060,"date":"2021-06-06T15:36:01","date_gmt":"2021-06-06T06:36:01","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4051"},"modified":"2021-06-06T15:40:00","modified_gmt":"2021-06-06T06:40:00","slug":"characteristics-of-cytokine-storms-caused-by-highly-pathogenic-virus-infections-including-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/characteristics-of-cytokine-storms-caused-by-highly-pathogenic-virus-infections-including-sars-cov-2\/","title":{"rendered":"Characteristics of cytokine storms caused by\u00a0highly pathogenic virus infections including SARS-CoV-2"},"content":{"rendered":"

Highly pathogenic virus infections usually trigger cytokine storms, which may have adverse effects on vital organs and result in high mortalities.
\nSichuan Agricultural University, China has investigated characteristics of cytokine storms caused by the following viruses: three coronaviruses (SARS-CoV, MERS-CoV, and SARS-CoV-2), three influenza viruses (2009H1N1, H5N1 and H7N9), Ebola virus, HIV, dengue virus, Zika virus, West Nile virus, HBV, HCV, and enterovirus, and has found three characteristics in the cytokine storms.
\nhttps:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.659419\/full<\/a><\/p>\n

IP-10, L-6, IL-8, and IL-17 Are the Most Increased Cytokines<\/strong><\/p>\n

Variations of IFN-\u03b3 and IL-4 Determine the Maximum Amplitude of All Cytokines<\/strong>
\nThe two cytokines IL-4 and IFN-\u03b3 play major roles in the generation and regulation of immune responses. Central in this respect are their mutually antagonistic functions. IFN-\u03b3 plays a key role in the inhibition of Th2-cell differentiation and Th1-cell stabilization; IL-4 promotes Th2-cell differentiation and stability and inhibits Th1-cell differentiation. The amplification factor should be the ratio of IFN-\u03b3 FC\/IL-4 FC (if IFN-\u03b3 FC\/IL-4 FC < 1, the amplification factor should be the ratio of IL-4 FC\/IFN-\u03b3 FC). Correlation between [IFN-\u03b3 FC \u00d7 (IFN-\u03b3 FC\/IL-4 FC) (if IFN-\u03b3 FC\/IL-4 FC > 1)] or [IFN-\u03b3 FC \u00d7 (IL-4 FC\/IFN-\u03b3 FC) (if IFN-\u03b3 FC\/IL-4 FC < 1)] and the max FC was calculated and a very high correlation coefficient R2 = 0.988 was obtained.\n\n\"\"<\/a><\/p>\n

viral load is weakly positive-correlated with IFN-\u03b3 FC, and virus clearance rate is negatively correlated with IFN-\u03b3 FC<\/strong><\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Highly pathogenic virus infections usually trigger cytokine storms, which may have adverse effects on vital or<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-4060","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t