{"id":4027,"date":"2021-06-02T13:54:15","date_gmt":"2021-06-02T04:54:15","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4020"},"modified":"2021-06-02T13:59:45","modified_gmt":"2021-06-02T04:59:45","slug":"urinary-biomarker-for-prostate-cancer-core-fucosylated-psa-could-be-a-candidate","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/urinary-biomarker-for-prostate-cancer-core-fucosylated-psa-could-be-a-candidate\/","title":{"rendered":"Urinary biomarker for prostate cancer: Core-fucosylated PSA could be a candidate\u00a0"},"content":{"rendered":"<p>A group from Hirosaki University Graduate School of Medicine, has reviewed current status of urinary biomarker for prostate cancer.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8100853\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8100853\/<\/a><\/p>\n<p>At this moment, FDA approved marker for prostate cancer (PC) is just one, i.e., Serum PSA. The ratio of complex biantennary glycans of \u03b1-2,3-sialic acid (S2,3PSA) and \u03b1-2,6-sialic acid (S2,6PSA) in serum is closely linked to aggressive PC.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28241428\/\">\u03b12,3-linked Sialyl N-Glycan-Carrying Prostate-Specific Antigen<\/a><br \/>\nHowever, this is not replicated in the urinary PSA.<\/p>\n<p>In the case of urinary PSA, it was thought that fucosylation of PSA could be a marker for PC. It has been found that Lewis-type or core-fucosylated PSA (detected by lectins such as AAL or PhoSL) was significantly decreased in PC. Also, core-fucosylated PSA was significantly associated with the Gleason scores of the biopsy specimens. The AUC for the prediction of prostate cancers of Gleason score \u22657 was 0.69 (P=0.0064) for urinary PSA-AAL and 0.72 (P=0.0014) for urinary PSA-PhoSL.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27494861\/\">Decreased fucosylated PSA as a urinary marker<\/a>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Hirosaki University Graduate School of Medicine, has reviewed current status of urinary biomarker<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/urinary-biomarker-for-prostate-cancer-core-fucosylated-psa-could-be-a-candidate\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-4027","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4027"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4027\/revisions"}],"predecessor-version":[{"id":4029,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4027\/revisions\/4029"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}