{"id":4017,"date":"2021-06-02T09:29:30","date_gmt":"2021-06-02T00:29:30","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3994"},"modified":"2021-06-02T09:32:22","modified_gmt":"2021-06-02T00:32:22","slug":"mirna-profiles-could-be-good-markers-for-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/mirna-profiles-could-be-good-markers-for-covid-19\/","title":{"rendered":"miRNA profiles could be good markers for COVID-19\u00a0"},"content":{"rendered":"<p>A group from University Hospital Arnau de Vilanova and Santa Maria, Spain, etc. has reported that miRNA profiles could be good markers for COVID-19<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8149473\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8149473\/<\/a><\/p>\n<p>The expression levels of circulating miRNAs were compared between ward and ICU patients. Ten of 41 miRNAs were differentially detected.<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/miRNA_COVID-19.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/miRNA_COVID-19-300x176.png\" alt=\"\" width=\"300\" height=\"176\" class=\"alignleft size-medium wp-image-3995\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/miRNA_COVID-19-300x176.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/miRNA_COVID-19-600x351.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/miRNA_COVID-19-768x450.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/miRNA_COVID-19.png 857w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Multivariate predictive models were constructed to discriminate ward patients from ICU patients, and the obtained AUC reached 0.89 (95% CI: 0.81-0.97) which was comparable to, or even higher than, that observed for the contemporaneous test proposed as biomarkers of COVID-19 severity, such as leukocyte counts (AUC=0.72), D-dimer (AUC=0.87) or CRP AUC=0.72).<\/p>\n<p>Additionally, it was studied whether the circulating miRNA signature constitutes a predictor of mortality in critically ill patients or not. Six miRNAs (miR-16-5p (FC=0.69), miR-92a-3p (FC=0.78), miR-98-5p (FC=0.56), miR-132-3p (FC=0.69), miR-192-5p (FC=0.66) and miR-323a-3p (FC=0.66)) showed significant suppression in patients who did not survive the ICU stay. The multivariable analysis selected a signature based on two miRNAs (miR-192-5p and miR-323a-3p) that was could be a predictor of mortality during the ICU stay [AUC\u202f=\u202f0.80 (0.64-0.96)].\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from University Hospital Arnau de Vilanova and Santa Maria, Spain, etc. has reported that miRNA profil<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/mirna-profiles-could-be-good-markers-for-covid-19\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-4017","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4017","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4017"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4017\/revisions"}],"predecessor-version":[{"id":4019,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4017\/revisions\/4019"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4017"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4017"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}