{"id":3999,"date":"2021-06-01T16:20:10","date_gmt":"2021-06-01T07:20:10","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3999"},"modified":"2021-07-21T23:07:52","modified_gmt":"2021-07-21T14:07:52","slug":"%e9%aa%a8%e9%ab%84%e7%b3%bb%e7%b4%b0%e8%83%9e%e4%b8%8a%e3%81%aec%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3-dc-sign-l-sign-lsectin-asgr1-clec10a-%e3%81%8c%e3%80%81covid-19%e3%81%ae%e9%81%8e","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e9%aa%a8%e9%ab%84%e7%b3%bb%e7%b4%b0%e8%83%9e%e4%b8%8a%e3%81%aec%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3-dc-sign-l-sign-lsectin-asgr1-clec10a-%e3%81%8c%e3%80%81covid-19%e3%81%ae%e9%81%8e\/","title":{"rendered":"\u9aa8\u9ac4\u7cfb\u7d30\u80de\u4e0a\u306eC\u578b\u30ec\u30af\u30c1\u30f3 (DC-SIGN, L-SIGN, LSECtin, ASGR1, CLEC10A) \u304c\u3001COVID-19\u306e\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u8a98\u8d77\u3059\u308b"},"content":{"rendered":"<p>New York University Grossman School of Medicine\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u9aa8\u9ac4\u7cfb\u7d30\u80de\uff08\u5358\u7403\u3001\u6a39\u72b6\u7d30\u80de\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3089\u306b\u5206\u5316\uff09\u306eC\u578b\u30ec\u30af\u30c1\u30f3\u304c\u3001COVID-19\u306e\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u8a98\u8d77\u3059\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8106883\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8106883\/<\/a><\/p>\n<p>\u9aa8\u9ac4\u7cfb\u7d30\u80de\u306b\u767a\u73fe\u3059\u308b5\u3064\u306eC\u578b\u30ec\u30af\u30c1\u30f3\u53d7\u5bb9\u4f53\uff08DC-SIGN\u3001L-SIGN\u3001LSECtin\u3001ASGR1\u3001CLEC10A\uff09\u304a\u3088\u3073Tweety family member 2 (TTYH2)\u306ecDNA\u3092\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30c8\u3057\u305fHEK293T\u7d30\u80de\u3068\u3001\u30d2\u30c8\u306eIgG\u306eFc\u90e8\u3092\u878d\u5408\u3055\u305b\u305fSARS-CoV-2 Spike\u3001S1\u3001RBD\u3068\u306e\u7d50\u5408\u6027\u3092\u8abf\u3079\u307e\u3057\u305f\u3002HEK293T\u306b\u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u3088\u3063\u3066\u767a\u73fe\u3055\u305b\u305f\u9aa8\u9ac4\u7cfb\u7d30\u80de\u306e\u305d\u308c\u3089\u53d7\u5bb9\u4f53\u304c\u3001SARS-CoV-2\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u3068\u3055\u308c\u308bACE2\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001SARS-CoV-2\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u660e\u78ba\u306b\u793a\u3055\u308c\u307e\u3057\u305f\u3002DC-SIGN\u3001L-SIGN\u3001ASGR1\u3001CLEC10A\u306f\u3001His\u30bf\u30b0\u4ed8\u304d\u306e\u53ef\u6eb6\u6027ACE2\u3092\u52a0\u3048\u3066\u3082\u3001\u305d\u306e\u7d50\u5408\u306f\u5168\u304f\u963b\u5bb3\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001ACE2\u81ea\u8eab\u3068LSECtin\u306fHis\u30bf\u30b0\u4ed8\u304d\u306e\u53ef\u6eb6\u6027ACE2\u3088\u3063\u3066\u898b\u4e8b\u306b\u963b\u5bb3\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001DC-SIGN\u3068L-SIGN\u306e\u7d50\u5408\u306f\u3001Mannan\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u3067\u5b8c\u5168\u306b\u963b\u5bb3\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/C-type-lectins_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4001\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/C-type-lectins_SARS-CoV-2-300x231.png\" alt=\"\" width=\"300\" height=\"231\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/C-type-lectins_SARS-CoV-2-300x231.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/C-type-lectins_SARS-CoV-2-600x463.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/C-type-lectins_SARS-CoV-2.png 686w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u66f4\u306b\u3001SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u3057\u305fGFP\u3092\u30a8\u30f3\u30b3\u30fc\u30c9\u3057\u305fHIV\u30d9\u30fc\u30b9\u306e\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2 \u507d\u30a6\u30a4\u30eb\u30b9\uff09\u3092\u7528\u3044\u3066\u3082\u540c\u69d8\u306a\u5b9f\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u4e0a\u8a18\u306e\u3088\u3046\u306b\u3057\u3066\u4f5c\u3089\u308c\u305fHEK293T\u3068SARS-CoV-2 \u507d\u30a6\u30a4\u30eb\u30b9\u3092\u5171\u57f9\u990a\u3059\u308b\u3068\u3001ACE2\u3092\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u3057\u305fHEK293T\u3068\u540c\u3058\u3088\u3046\u306b\u3001\u5f37\u3044GFP\u306e\u4fe1\u53f7\u304cDC-SIGN\u3068L-SIGN\u306e\u305d\u308c\u3089\u304b\u3089\u3082\u89b3\u6e2c\u3055\u308c\u307e\u3057\u305f\u3002 LSECtin\u3001ASGR1\u3001CLEC10A\u304a\u3088\u3073TTYH2\u304b\u3089\u306eGFP\u306e\u4fe1\u53f7\u306f\u975e\u5e38\u306b\u5f31\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001furin \u3084 TMPRSS2 \u3092\u5171\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u3057\u305f\u3082\u306e\u3067\u306f\u3001\u305d\u306e\u4fe1\u53f7\u304c\u5f37\u8abf\u3055\u308c\u307e\u3057\u305f\u3002Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b9f\u9a13\u3067\u3001Mannan\u3067\u7d50\u5408\u304c\u963b\u5bb3\u3055\u308c\u305f\u3088\u3046\u306b\u3001\u3053\u306e\u5834\u5408\u3067\u3082\u3001DC-SIGN\u3001L-SIGN\u306eSARS-CoV-2\u507d\u30a6\u30a4\u30eb\u30b9\u306b\u3088\u3063\u3066\u8a98\u8d77\u3055\u308c\u305fGFP\u306e\u4fe1\u53f7\u306f\u3001Mannan\u306b\u3088\u3063\u3066\u898b\u4e8b\u306b\u963b\u5bb3\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001SARS-CoV-2 \u507d\u30a6\u30a4\u30eb\u30b9\u3067\u3082\u9aa8\u9ac4\u7cfb\u7d30\u80de\u306e\u53d7\u5bb9\u4f53\u304cSARS-CoV-2\u306eSpike\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5909\u308f\u3089\u306c\u95a2\u4fc2\u6027\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/SARS-CoV-2-pseudovirus_C-type-lectin.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4007\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/SARS-CoV-2-pseudovirus_C-type-lectin-300x190.png\" alt=\"\" width=\"300\" height=\"190\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/SARS-CoV-2-pseudovirus_C-type-lectin-300x190.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/06\/SARS-CoV-2-pseudovirus_C-type-lectin.png 482w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>New York University Grossman School of Medicine\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u9aa8\u9ac4\u7cfb\u7d30\u80de\uff08\u5358\u7403\u3001\u6a39\u72b6\u7d30\u80de\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3089\u306b\u5206\u5316\uff09\u306eC\u578b\u30ec\u30af\u30c1\u30f3\u304c\u3001COVID-19\u306e\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u8a98\u8d77\u3059<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e9%aa%a8%e9%ab%84%e7%b3%bb%e7%b4%b0%e8%83%9e%e4%b8%8a%e3%81%aec%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3-dc-sign-l-sign-lsectin-asgr1-clec10a-%e3%81%8c%e3%80%81covid-19%e3%81%ae%e9%81%8e\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-3999","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3999"}],"version-history":[{"count":10,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3999\/revisions"}],"predecessor-version":[{"id":5081,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3999\/revisions\/5081"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}