{"id":3926,"date":"2021-05-24T12:25:30","date_gmt":"2021-05-24T03:25:30","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3926"},"modified":"2021-07-21T23:08:48","modified_gmt":"2021-07-21T14:08:48","slug":"sars-cov-2%e6%84%9f%e6%9f%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bc%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%ae%e5%bd%b9%e5%89%b2%e3%81%af%e3%83%88%e3%83%a9%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e6%84%9f%e6%9f%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bc%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%ae%e5%bd%b9%e5%89%b2%e3%81%af%e3%83%88%e3%83%a9%e3%83%b3\/","title":{"rendered":"SARS-CoV-2\u611f\u67d3\u306b\u304a\u3051\u308bC\u578b\u30ec\u30af\u30c1\u30f3\u53d7\u5bb9\u4f53\u306e\u5f79\u5272\u306f\u30c8\u30e9\u30f3\u30b9\u611f\u67d3\u3068\u8003\u3048\u3089\u308c\u308b"},"content":{"rendered":"<p>Univ. Grenoble Alpes, France\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001C\u578b\u30ec\u30af\u30c1\u30f3\u3092\u4ecb\u3057\u305fSARS-CoV-2\u611f\u67d3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/journals.plos.org\/plospathogens\/article\/authors?id=10.1371\/journal.ppat.1009576\">https:\/\/journals.plos.org\/plospathogens\/article\/authors?id=10.1371\/journal.ppat.1009576<\/a><\/p>\n<p>\u5404\u7a2eC\u578b\u30ec\u30af\u30c1\u30f3\uff08DC-SIGN\u3001L-SIGN\u3001MGL\u3001Langerin\uff09\u3068SARS-CoV-2 spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u3092SPR\u3092\u7528\u3044\u3066\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002DC-SIGN\u3001L-SIGN\u3001MGL\u306f\u3001Kd\u5024\u3068\u3057\u3066 \u03bcM\u30ec\u30f3\u30b8\u306e\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\uff082 \uff5e 10 \u03bcM\uff09\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001Langerin\u306f\u5c11\u306a\u304f\u3068\u3082\uff11\u6841\u4ee5\u4e0a\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u304c\u4f4e\u3044\u3068\u5224\u65ad\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>C\u578b\u30ec\u30af\u30c1\u30f3\u306eSARS-CoV-2\u611f\u67d3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7406\u89e3\u3059\u308b\u70ba\u306b\u3001\u5358\u7403\u7531\u6765\u6a39\u72b6\u7d30\u80de\uff08MDDC)\u3001\u5358\u7403\u7531\u6765\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08M2-MDM\uff09\u304a\u3088\u3073Vero E6\u7d30\u80de\u3092\u4f7f\u7528\u3057\u305f\u611f\u67d3\u5b9f\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002 \u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001VSV\/SARS-CoV-2 \u7591\u4f3c\u30a6\u30a4\u30eb\u30b9\u306f\u3001MDDC\u3084M2-MDM\u304cDC-SIGN\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u76f4\u63a5\u7684\u306b\u306f\u307e\u3063\u305f\u304f\u611f\u67d3\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001VSV\/EBOV-GP\u7591\u4f3c\u30a6\u30a4\u30eb\u30b9\u306e\u5834\u5408\u306b\u306f\u3001\u305d\u306e\u76f4\u63a5\u611f\u67d3\u304c\u8a8d\u3081\u3089\u308c\u3001DC-SIGN\u3092\u4ecb\u3057\u305f\u30b7\u30b9\u611f\u67d3\u304c\u6297DC\/L-SIGN\u6297\u4f53\u306b\u3088\u3063\u3066\u963b\u5bb3\u3055\u308c\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f\uff08MDDC\u306e\u5834\u5408\u306792.5%\u306e\u963b\u5bb3\u3001M2-MDM\u306e\u5834\u5408\u306768.4%\u306e\u963b\u5bb3\u3067\u3057\u305f\uff09\u3002\u4e00\u65b9\u3001VSV\/VSV-G\u7591\u4f3c\u30a6\u30a4\u30eb\u30b9\u306f\u3001MDDC\u306b\u3082M2-MDM\u306b\u3082\u5f37\u304f\u611f\u67d3\u3057\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u611f\u67d3\u306fDC-SIGN\u3068\u306f\u7121\u95a2\u4fc2\u3067\u3042\u308a\u307e\u3059\u3002\u5b9f\u969b\u3001\u6297DC-SIGN\u6297\u4f53\u306fEbola Virus\u306e\u611f\u67d3\u306b\u5bfe\u3057\u3066\u4f55\u306e\u5f71\u97ff\u3082\u4e0e\u3048\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>SARS-CoV-2\u611f\u67d3\u306b\u304a\u3051\u308bDC\/L-SIGN\u306e\u57fa\u672c\u7684\u306a\u5f79\u5272\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001MDDC\u3092SARS-CoV-2\u3068\u5171\u57f9\u990a\u3057\u3001\u305d\u306eMDDC\u3092Vero E6\u7d30\u80de\u306e\u57f9\u990a\u30d7\u30ec\u30fc\u30c8\u306b\u52a0\u3048\u3066\u307f\u307e\u3057\u305f\u3002\u56e0\u307f\u306b\u3001Vero E6\u7d30\u80de\u306fACE2\u3092\u767a\u73fe\u3059\u308b\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9\u7d30\u80de\u3068\u3057\u3066\u826f\u304f\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001DC-SIGN\u306f\u3001MDDC\u304b\u3089Vero E6\u3078\u306e SARS-CoV-2\u306e\u611f\u67d3\u3092\u4fc3\u9032\u3057\u307e\u3057\u305f\u3002\u6297DC-SIGN \u6297\u4f53\u3092\u30a2\u30d7\u30e9\u30a4\u3059\u308b\u3053\u3068\u3067\u3001\u611f\u67d3\u304c98\uff05\u3082\u963b\u5bb3\u3055\u308c\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5b9f\u9a13\u7d50\u679c\u306f\u3001DC\/L-SIGN\u306eSARS-CoV-2\u611f\u67d3\u306b\u304a\u3051\u308b\u5f79\u5272\u304c\u3001\u30c8\u30e9\u30f3\u30b9\u611f\u67d3\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u304f\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/MDDC-trans-infection_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/MDDC-trans-infection_SARS-CoV-2-300x164.png\" alt=\"\" width=\"300\" height=\"164\" class=\"alignleft size-medium wp-image-3932\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/MDDC-trans-infection_SARS-CoV-2-300x164.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/MDDC-trans-infection_SARS-CoV-2-600x329.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/MDDC-trans-infection_SARS-CoV-2-1024x561.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/MDDC-trans-infection_SARS-CoV-2-768x421.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/MDDC-trans-infection_SARS-CoV-2.png 1052w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Univ. Grenoble Alpes, France\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001C\u578b\u30ec\u30af\u30c1\u30f3\u3092\u4ecb\u3057\u305fSARS-CoV-2\u611f\u67d3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/journals.plos.org\/plospat<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2%e6%84%9f%e6%9f%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bc%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%ae%e5%bd%b9%e5%89%b2%e3%81%af%e3%83%88%e3%83%a9%e3%83%b3\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-3926","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3926"}],"version-history":[{"count":10,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3926\/revisions"}],"predecessor-version":[{"id":5083,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3926\/revisions\/5083"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}