{"id":3901,"date":"2021-05-22T11:51:47","date_gmt":"2021-05-22T02:51:47","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3894"},"modified":"2021-05-22T11:56:36","modified_gmt":"2021-05-22T02:56:36","slug":"characteristics-of-cross-reactive-serum-and-memory-b-cells-between-sars-cov-2-and-endemic-hcovs","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/characteristics-of-cross-reactive-serum-and-memory-b-cells-between-sars-cov-2-and-endemic-hcovs\/","title":{"rendered":"Characteristics of cross-reactive serum and memory B-cells between SARS-CoV-2 and endemic HCoVs\u00a0"},"content":{"rendered":"<p>A group from Scripps Research Institute has reported about characteristics of cross-reactive serum and memory B-cells between SARS-CoV-2 and endemic HCoVs.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-23074-3\">https:\/\/www.nature.com\/articles\/s41467-021-23074-3<\/a><\/p>\n<p>COVID-19 convalescent sera from 36 donors showed strong reactivity to the SARS-CoV-2 spike in the vast majority of infected donors, somewhat lower reactivity with the SARS-CoV-1 spike and much lower reactivity with the MERS-CoV spike. COVID-19 sera also exhibited strong cross-reactivity with endemic HCoV spikes, especially with the HCoV-HKU1 and HCoV-OC43 \u03b2-HCoVs. The \u03b1-HCoV-derived HCoV-NL63 spike was least reactive among the four endemic HCoVs. From a cohort of 36 HIV seropositive but otherwise healthy human donors whose samples were collected SARS-CoV-2 pre-pandemic. The sera showed almost no reactivity to SARS-CoV-2\/CoV-1 and MERS-CoV spikes but showed strong binding to the endemic HCoV spikes, especially against the HCoV-HKU1 and HCoV-OC43 \u03b2-HCoVs (see a figure below). <\/p>\n<p>In sera from SARS-CoV-2 pre-pandemic cohort, there was no evidence of pre-existing SARS-CoV-2 S-protein reactive antibodies that resulted from endemic HCoV infections. A recent study has, however, reported the presence of SARS-CoV-2 S-protein reactive antibodies in a small fraction of pre-pandemic human sera from children and adolescents as explained in the following paper.<br \/>\n<a href=\"https:\/\/science.sciencemag.org\/content\/370\/6522\/1339.long\">Preexisting immunity to SARS-CoV-2 before the pandemic<\/a><\/p>\n<p>The SARS-CoV-2\/HKU1-CoV cross-reactive mAbs failed to bind any of the S1 subunit domains or subdomains, suggesting targeting to the more conserved S2 subunit<\/p>\n<p>Interestingly, SARS-CoV-2 infection boosted titers to endemic HCoV-HKU1 S protein, but not for other HCoVs, suggesting that SARS-CoV-2 infection activated cross-reactive endemic HCoV-HKU1 S-protein-specific B cells.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/crossreactivity_coronavirus.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/crossreactivity_coronavirus-300x211.png\" alt=\"\" width=\"300\" height=\"211\" class=\"alignleft size-medium wp-image-3896\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/crossreactivity_coronavirus-300x211.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/crossreactivity_coronavirus-600x422.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/crossreactivity_coronavirus-1024x721.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/crossreactivity_coronavirus-768x541.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/crossreactivity_coronavirus.png 1301w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Scripps Research Institute has reported about characteristics of cross-reactive serum and memory <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/characteristics-of-cross-reactive-serum-and-memory-b-cells-between-sars-cov-2-and-endemic-hcovs\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3901","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3901"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3901\/revisions"}],"predecessor-version":[{"id":3903,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3901\/revisions\/3903"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}