{"id":3853,"date":"2021-05-20T19:02:09","date_gmt":"2021-05-20T10:02:09","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3847"},"modified":"2021-05-20T19:14:51","modified_gmt":"2021-05-20T10:14:51","slug":"sars-cov-2-has-a-ganglioside-binding-domain-in-its-ntd","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/sars-cov-2-has-a-ganglioside-binding-domain-in-its-ntd\/","title":{"rendered":"SARS-CoV-2 has a Ganglioside binding domain in its NTD\u00a0"},"content":{"rendered":"<p>A group from Aix-Marseille Universit\u00e9, France has reported that there is a ganglioside binding domain in SARS-CoV-2 NTD.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7547605\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7547605\/<\/a><\/p>\n<p>Residues 111-162 would be a ganglioside binding domain, and the binding could be inhibited by azithromycin which is a sugar-containing macrolide antibiotic which has some ganglioside mimicry properties, and also by 4A8 antibody that has been characterized in convalescent Covid-19 patients recognizes a discontinuous epitope of the NTD.<\/p>\n<p>The figure blow shows an idea that the NTD binding to gangliosides induces the coalescence of lipid rafts together with a local modulation of membrane curvature that may facilitate the recruitment of the ACE-2 receptor. <\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ganglioside_SARS-CoV-2-NTD.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ganglioside_SARS-CoV-2-NTD-300x190.png\" alt=\"\" width=\"300\" height=\"190\" class=\"alignleft size-medium wp-image-3849\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ganglioside_SARS-CoV-2-NTD-300x190.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ganglioside_SARS-CoV-2-NTD-600x379.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ganglioside_SARS-CoV-2-NTD-768x485.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ganglioside_SARS-CoV-2-NTD.png 995w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Aix-Marseille Universit\u00e9, France has reported that there is a ganglioside binding domain in SARS-<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/sars-cov-2-has-a-ganglioside-binding-domain-in-its-ntd\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3853","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3853","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3853"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3853\/revisions"}],"predecessor-version":[{"id":3854,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3853\/revisions\/3854"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3853"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}