{"id":3785,"date":"2021-05-18T13:58:54","date_gmt":"2021-05-18T04:58:54","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3767"},"modified":"2021-05-18T14:02:17","modified_gmt":"2021-05-18T05:02:17","slug":"effects-of-b-1-427-b-1-429-sars-cov-2-variants-onto-infectivity-and-neutralization","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/effects-of-b-1-427-b-1-429-sars-cov-2-variants-onto-infectivity-and-neutralization\/","title":{"rendered":"Effects of B.1.427\/B.1.429 SARS-CoV-2 variants onto infectivity and neutralization\u00a0"},"content":{"rendered":"<p>A group from University of California, San Francisco has reported effects of B.1.427\/B.1.429 SARS-CoV-2 variants onto infectivity and neutralization.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33991487\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33991487\/<\/a><\/p>\n<p>Famous SARS-CoV-2 variants are B.1.1.7(originally detected in UK), B.1.351(South Africa), and P.1(Brazil) variants. The B.1.1.7 variant is characterized by N501Y mutation, and the B.1.351 and P.1 carry E484K, K417N\/K417T in addition to N501Y mutations.<br \/>\nB.1.427\/B.1.429 variants appeared in California from September, 2020 are characterized by S13I, W152C, L452R mutations in the spike protein coding domain, and L452R is in RBD.<\/p>\n<p>These variants showed 18.6%\u201324% increased transmissibility relative to wild-type circulating strains, and antibody neutralization assays revealed 4.0- to 6.7-fold decrease in neutralizing titer from convalescent patients and 2.0-fold decreases in neutralizing titers from vaccine recipients, respectively<\/p>\n<p>The reason of this change could be due to structural changes in the RBD which are caused by formation of a hydrophobic patch on the surface of spike RBD by L452 together with F490 and L492.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/L452-mutation_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/L452-mutation_SARS-CoV-2-257x300.png\" alt=\"\" width=\"257\" height=\"300\" class=\"alignleft size-medium wp-image-3778\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/L452-mutation_SARS-CoV-2-257x300.png 257w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/L452-mutation_SARS-CoV-2.png 432w\" sizes=\"auto, (max-width: 257px) 100vw, 257px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from University of California, San Francisco has reported effects of B.1.427\/B.1.429 SARS-CoV-2 varian<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/effects-of-b-1-427-b-1-429-sars-cov-2-variants-onto-infectivity-and-neutralization\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3785","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3785"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3785\/revisions"}],"predecessor-version":[{"id":3787,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3785\/revisions\/3787"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}