{"id":3695,"date":"2021-05-16T09:13:05","date_gmt":"2021-05-16T00:13:05","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3695"},"modified":"2021-07-21T23:11:38","modified_gmt":"2021-07-21T14:11:38","slug":"sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%a7%e3%81%82%e3%82%8bace2%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%8c%e3%80%81%e8%87%aa%e7%84%b6%e5%85%8d%e7%96%ab%e3%82%b7%e3%82%b0","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%a7%e3%81%82%e3%82%8bace2%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%8c%e3%80%81%e8%87%aa%e7%84%b6%e5%85%8d%e7%96%ab%e3%82%b7%e3%82%b0\/","title":{"rendered":"SARS-CoV-2\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u3067\u3042\u308bACE2\u306e\u767a\u73fe\u304c\u3001\u81ea\u7136\u514d\u75ab\u30b7\u30b0\u30ca\u30eb\u30d1\u30b9\uff08Toll\u69d8\u53d7\u5bb9\u4f53\uff09\u306e\u6d3b\u6027\u5316\u3067\u4e0a\u6607\u3059\u308b\u3089\u3057\u3044"},"content":{"rendered":"<p>\u5317\u6d77\u9053\u5927\u5b66\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001ACE2\u3068TMPRSS2\u306e\u767a\u73fe\u306b\u5bfe\u3057\u3066\u3001\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff09\u306e\u30a2\u30b4\u30cb\u30b9\u30c8\u3001\u53ca\u3073\u30d5\u30eb\u30c1\u30ab\u30be\u30f3\u70b9\u9f3b\u85ac\uff08FP\uff09\u304c\u5982\u4f55\u306a\u308b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8107375\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8107375\/<\/a><\/p>\n<p>SARS-CoV-2\u306e\u611f\u67d3\u306b\u3064\u3044\u3066\u306f\u3001\u5bbf\u4e3b\u7d30\u80de\u8868\u9762\u306b\u5b58\u5728\u3059\u308b\u4e8c\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3001angiotensin-converting enzyme 2\uff08ACE2\uff09\u3001\u53ca\u3073transmembrane protease serine 2\uff08TMPRSS2\uff09\u304c\u4e3b\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8457\u8005\u3089\u306f\u3001\u81ea\u7136\u514d\u75ab\u306e\u30b7\u30b0\u30ca\u30eb\u30d1\u30b9\u306e\u6d3b\u6027\u5316\u304cACE2\u3084TMPRSS2\u306e\u767a\u73fe\u306b\u5982\u4f55\u306a\u308b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\uff1f\u305d\u3057\u3066\u307e\u305fFP\u306e\u6295\u4e0e\u304c\u3069\u3093\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\uff1f\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5b9f\u9a13\u7d30\u80de\u3068\u3057\u3066\u3001\u9f3b\u8154\u7c98\u819c\u304b\u3089\u53d6\u5f97\u3055\u308c\u305f\u30d2\u30c8\u9f3b\u8154\u4e0a\u76ae\u7d30\u80de\uff08HNECs\uff09\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002HNECs\u3092Poly(I:C) \u3067\u523a\u6fc0\u3057\u307e\u3057\u305f\u3002Poly(I:C) \u306fdouble-stranded RNA (dsRNA) \u3067\u3042\u308a\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306e\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u3057\u3070\u3057\u3070TLRs\u306e\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>ACE2\u3068TMPRSS2\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u306f\u3001\u514d\u75ab\u67d3\u8272\u3089\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002ACE2\u306e\u767a\u73fe\u91cf\u306f\u3001\u9855\u8457\u306bPoly(I:C) \u306e\u523a\u6fc0\u306b\u3088\u3063\u3066\u4e0a\u6607\u3057\u307e\u3057\u305f\u304c (2.884\u00b10.505-fold change vs. untreated cells, p=0.003)\u3001TMPRSS2\u306b\u95a2\u3057\u3066\u306f\u7d71\u8a08\u7684\u306a\u8aa4\u5dee\u306e\u7bc4\u56f2\u3067\u9855\u8457\u306a\u5dee\u306f\u307f\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306ePoly(I:C) \u523a\u6fc0\u306b\u3088\u3063\u3066\u767a\u73fe\u4e0a\u6607\u3057\u305fACE2\u306f\u3001FP\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (0.405\u00b10.312-fold change vs. Poly(I:C)-treated cells, p=0.044)\u3002<\/p>\n<p>FP\u304cSARS-CoV-2\u306e\u611f\u67d3\u3092\u62bc\u3055\u3048\u308b\u52b9\u679c\u304c\u3042\u308b\u306e\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u66f4\u306bin vivo\u3067\u306e\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-TLR-agonist-FP.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-TLR-agonist-FP-300x135.png\" alt=\"\" width=\"300\" height=\"135\" class=\"alignleft size-medium wp-image-3696\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-TLR-agonist-FP-300x135.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-TLR-agonist-FP-600x269.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-TLR-agonist-FP-768x344.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-TLR-agonist-FP.png 836w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u6d77\u9053\u5927\u5b66\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001ACE2\u3068TMPRSS2\u306e\u767a\u73fe\u306b\u5bfe\u3057\u3066\u3001\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff09\u306e\u30a2\u30b4\u30cb\u30b9\u30c8\u3001\u53ca\u3073\u30d5\u30eb\u30c1\u30ab\u30be\u30f3\u70b9\u9f3b\u85ac\uff08FP\uff09\u304c\u5982\u4f55\u306a\u308b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.ncbi.n<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%a7%e3%81%82%e3%82%8bace2%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%8c%e3%80%81%e8%87%aa%e7%84%b6%e5%85%8d%e7%96%ab%e3%82%b7%e3%82%b0\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-3695","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3695"}],"version-history":[{"count":6,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3695\/revisions"}],"predecessor-version":[{"id":5090,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3695\/revisions\/5090"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}