{"id":3668,"date":"2021-05-13T10:22:31","date_gmt":"2021-05-13T01:22:31","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3656"},"modified":"2021-05-13T10:27:03","modified_gmt":"2021-05-13T01:27:03","slug":"a-positive-result-from-a-phase-3-clinical-trial-of-lenzilumab-against-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-positive-result-from-a-phase-3-clinical-trial-of-lenzilumab-against-covid-19\/","title":{"rendered":"A positive result from a Phase 3 clinical trial of Lenzilumab against COVID-19\u00a0"},"content":{"rendered":"<p>A group from Mayo Clinic, etc. has reported a promising result of a phase 3 clinical trial of Lenzilumab against COVID-19.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33972949\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33972949\/<\/a><\/p>\n<p>In COVID-19, it has been known that high levels of granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting T-cells are associated with disease severity, myeloid cell trafficking to the lungs, and ICU admission. GM-CSF is a kind of cytokine which activates differentiation of myeloid cells, leading to elevations of downstream inflammatory chemokines (MCP-1, IL-8, IP-10) and cytokines (IL-6, IL-1).<\/p>\n<p>Lenzilumab is a novel anti-human GM-CSF monoclonal antibody that directly binds GM-CSF and prevents signaling through its receptor. It has high binding affinity (25 pM) for glycosylated human GM-CSF and a slow off-rate. A phase 3 randomized, double-blind, placebo-controlled clinical trial was designed to demonstrate the effectiveness of lenzilumab. The dose of lenzilumab was 600mg and administered 8hours apart for 28 days. <\/p>\n<p>Lenzilumab could improve the likelihood of survival without ventilation (SWOV) through Day 28 by 54%. It should be noted that the improvement in SWOV was most evident in patients with CRP<150 mg\/L who are less than 85 years of age.\n\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/lenzilumab_COVID-19.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/lenzilumab_COVID-19-300x159.png\" alt=\"\" width=\"300\" height=\"159\" class=\"alignleft size-medium wp-image-3657\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/lenzilumab_COVID-19-300x159.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/lenzilumab_COVID-19-600x319.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/lenzilumab_COVID-19.png 744w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Mayo Clinic, etc. has reported a promising result of a phase 3 clinical trial of Lenzilumab again<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-positive-result-from-a-phase-3-clinical-trial-of-lenzilumab-against-covid-19\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3668","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3668","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3668"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3668\/revisions"}],"predecessor-version":[{"id":3670,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3668\/revisions\/3670"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}