{"id":3656,"date":"2021-05-13T10:22:31","date_gmt":"2021-05-13T01:22:31","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3656"},"modified":"2021-05-13T10:22:31","modified_gmt":"2021-05-13T01:22:31","slug":"lenzilumab%e3%80%81%e7%ac%ac3%e7%9b%b8%e6%b2%bb%e9%a8%93%e3%81%ab%e3%81%a6%e3%80%81covid-19%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%8c%e7%a4%ba","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/lenzilumab%e3%80%81%e7%ac%ac3%e7%9b%b8%e6%b2%bb%e9%a8%93%e3%81%ab%e3%81%a6%e3%80%81covid-19%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%8c%e7%a4%ba\/","title":{"rendered":"Lenzilumab\u3001\u7b2c3\u76f8\u6cbb\u9a13\u306b\u3066\u3001COVID-19\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u305f"},"content":{"rendered":"

Mayo Clinic\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306b\u5bfe\u3059\u308bLenzilumab\u306e\u7b2c3\u76f8\u6cbb\u9a13\u304b\u3089\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6709\u671b\u306a\u7d50\u679c\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/33972949\/<\/a><\/p>\n

COVID-19\u306b\u304a\u3044\u3066\u306f\u3001\u9846\u7c92\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u30fb\u30b3\u30ed\u30cb\u30fc\u523a\u6fc0\u56e0\u5b50\uff08GM-CSF\uff09\u304c\u75c5\u614b\u306e\u91cd\u75c7\u5ea6\u3001\u80ba\u7d44\u7e54\u3078\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u904a\u8d70\u3001ICU\u5165\u9662\u3089\u3068\u76f8\u95a2\u304c\u3042\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002GM-CSF\u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308a\u3001\u591a\u80fd\u6027\u9020\u8840\u5e79\u7d30\u80de\u306b\u5206\u5316\u3092\u4fc3\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u305d\u306e\u30c0\u30a6\u30f3\u30b9\u30c8\u30ea\u30fc\u30e0\u306b\u3042\u308b\u30b1\u30e2\u30ab\u30a4\u30f3 (MCP-1, IL-8, IP-10) \u3084\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3 (IL-6, IL-1)\u306e\u7523\u751f\u3092\u52a0\u901f\u3057\u307e\u3059\u3002<\/p>\n

Lenzilumab\u306f\u3001GM-CSF\u306b\u76f4\u63a5\u7684\u306b\u7d50\u5408\u3059\u308b\u6297\u4f53\u3067\u3042\u308a\u3001GS-CFS\u306e\u53d7\u5bb9\u4f53\u3078\u306e\u7d50\u5408\u3092\u963b\u5bb3\u3057\u3001\u305d\u306e\u30c0\u30a6\u30f3\u30b9\u30c8\u30ea\u30fc\u30e0\u3092\u906e\u65ad\u3057\u307e\u3059\u3002Lenzilumab\u306eGM-CSF\u3078\u306e\u7d50\u5408\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u306f25pM\u3067\u3042\u308a\u3001\u4f53\u5185\u3067\u306e\u6d88\u5931\u901f\u5ea6\u3082\u9045\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002 Lenzilumab\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u3001\u30c0\u30d6\u30eb\u30fb\u30d6\u30e9\u30a4\u30f3\u3001\u30d7\u30e9\u30bb\u30dc\u30fb\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u7528\u3044\u305f\u7b2c3\u76f8\u6cbb\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002Lenzilumab\u306e\u30c9\u30fc\u30ba\u306f600mg\u3067\u3042\u308a\u30018\u6642\u9593\u306e\u9593\u3092\u3042\u3051\u300128\u65e5\u9593\u306b\u308f\u305f\u3063\u3066\u9759\u8108\u6ce8\u5c04\u306b\u3066\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002 <\/p>\n

Lenzilumab\u306f\u3001survival without ventilation (SWOV) \u3092\u6307\u6a19\u3068\u3057\u3066\u300128\u65e5\u9593\u3092\u901a\u3057\u306654%\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u52b9\u679c\u306f\u3001CRP<150 mg\/L\u300185\u6b73\u4ee5\u4e0b\u3068\u3044\u3046\u6761\u4ef6\u306b\u9650\u3089\u308c\u308b\u3053\u3068\u306b\u6ce8\u610f\u3057\u307e\u3057\u3087\u3046\u3002 \n\n\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Mayo Clinic\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306b\u5bfe\u3059\u308bLenzilumab\u306e\u7b2c3\u76f8\u6cbb\u9a13\u304b\u3089\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6709\u671b\u306a\u7d50\u679c\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/pubmed.ncbi.nlm.nih.gov\/33972949<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-3656","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3656"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3656\/revisions"}],"predecessor-version":[{"id":3667,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3656\/revisions\/3667"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}