{"id":3638,"date":"2021-05-11T06:53:03","date_gmt":"2021-05-10T21:53:03","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3625"},"modified":"2021-05-11T06:56:04","modified_gmt":"2021-05-10T21:56:04","slug":"what-relationship-is-there-among-the-expression-levels-of-ace2-tmprss2-and-severity-of-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/what-relationship-is-there-among-the-expression-levels-of-ace2-tmprss2-and-severity-of-covid-19\/","title":{"rendered":"What relationship is there among the expression levels of ACE2, TMPRSS2, and severity of COVID-19?"},"content":{"rendered":"<p>A group from Universidade Federal do Rio de Janeiro, etc. has reported the relationship among the expression levels of ACE2, TMPRSS2, and severity of COVID-19.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-88944-8\">https:\/\/www.nature.com\/articles\/s41598-021-88944-8<\/a><\/p>\n<p>ACE2 and TMPRSS2 are known to be key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. The angiotensin-converting enzyme 2 (ACE2) has been described as the entry receptor for SARS-CoV-2 and the transmembrane serine protease 2 (TMPRSS2) as an important priming enzyme required during this process.<\/p>\n<p>A case\u2013control study was carried out including 213 individuals with SARS-CoV-2 infection confirmed by RT-qPCR in nasopharyngeal samples.<br \/>\nExpression of both genes of ACE2 and TMPRSS2 was positively correlated to age (r\u2009=\u20090.20; p\u2009=\u20090.03 and r\u2009=\u20090.21; p\u2009=\u20090.01 for ACE2 and TMPRSS2, respectively), while no association with sex was observed.<br \/>\nTranscription levels of ACE2 were significantly lower among cases than in controls, while similar levels of TMPRSS2 were observed in both groups. However, TMPRSS2\/ACE2 ratios were significantly higher among cases than those of controls. From blog admin&#8217;s point of view, It is interesting but quite difficult to understand that the expression levels of ACE2 showed a protective effect for the infection, no significant association between the levels of TMPRSS2 and the infection, but TMPRSS2\/ACE2 ratio could be a risk factor on COVID-19 severity, suggesting that other infection paths would be behind the ACE2\/TMPRSS2 infection path.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-and-TMPRSS2-expression-in-COVIOD-19.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-and-TMPRSS2-expression-in-COVIOD-19-300x94.png\" alt=\"\" width=\"300\" height=\"94\" class=\"alignleft size-medium wp-image-3627\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-and-TMPRSS2-expression-in-COVIOD-19-300x94.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-and-TMPRSS2-expression-in-COVIOD-19-600x188.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-and-TMPRSS2-expression-in-COVIOD-19-1024x322.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-and-TMPRSS2-expression-in-COVIOD-19-768x241.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/ACE2-and-TMPRSS2-expression-in-COVIOD-19.png 1277w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Universidade Federal do Rio de Janeiro, etc. has reported the relationship among the expression l<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/what-relationship-is-there-among-the-expression-levels-of-ace2-tmprss2-and-severity-of-covid-19\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3638","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3638","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3638"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3638\/revisions"}],"predecessor-version":[{"id":3640,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3638\/revisions\/3640"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3638"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}