{"id":3565,"date":"2021-05-07T08:15:18","date_gmt":"2021-05-06T23:15:18","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3565"},"modified":"2021-06-28T06:52:13","modified_gmt":"2021-06-27T21:52:13","slug":"sars-cov-2%e3%81%aentd%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%a8%e3%81%99%e3%82%8b%e4%b8%ad%e5%92%8c%e6%8a%97%e4%bd%93%e3%81%ae%e7%89%b9%e6%80%a7%e3%81%ab%e3%81%a4%e3%81%84","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%aentd%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%a8%e3%81%99%e3%82%8b%e4%b8%ad%e5%92%8c%e6%8a%97%e4%bd%93%e3%81%ae%e7%89%b9%e6%80%a7%e3%81%ab%e3%81%a4%e3%81%84\/","title":{"rendered":"SARS-CoV-2\u306eNTD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u4e2d\u548c\u6297\u4f53\u306e\u7279\u6027\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>Israel Institute for Biological Research\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306eNTD\u306b\u5bfe\u3059\u308b12\u7a2e\u985e\u306e\u4e2d\u548c\u6297\u4f53\u306e\u7279\u6027\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33937725\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33937725\/<\/a><\/p>\n<p>12\u7a2e\u985e\u306eSARS-CoV-2 NTD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u6297\u4f53 (BLN1 \uff5e BLN14) \u306f\u52b9\u679c\u7684\u306bSARS-CoV-2\u3092\u4e2d\u548c\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u305d\u306eIC<sub>50<\/sub>\u306f\u3001\u6700\u3082\u4f4e\u3044\u4e2d\u548c\u6d3b\u6027\u306eBLN8\u306754.9 \u00b5g\/ml\u3001\u6700\u3082\u9ad8\u3044\u4e2d\u548c\u6d3b\u6027\u3092\u793a\u3059BNL1\u3084BLN12\u30670.008 \u00b5g\/ml\u3001\u306b\u5206\u5e03\u3057\u307e\u3057\u305f\u3002\u3000\u3053\u308c\u3089\u3059\u3079\u3066\u306e\u6297\u4f53\u306e\u7279\u7570\u6027\u306f\u3001NTD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308bELISA\u306b\u3066\u691c\u8a3c\u3055\u308c\u3001\u3088\u308a\u8a73\u7d30\u306b\u306f\u3001S1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u914d\u5217\u304b\u3089\u4f5c\u3089\u308c\u305f\u30da\u30d7\u30c1\u30c9\u30a2\u30ec\u30a4\u306b\u3088\u308b\u30a8\u30d4\u30c8\u30fc\u30d7\u30de\u30c3\u30d4\u30f3\u30b0\u306b\u3066\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002 \u305d\u3057\u3066\u307e\u305f\u3001NTD\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u6297\u4f53\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u3001\u7cd6\u9396\u30a2\u30ec\u30a4\u3001\u53ca\u3073\u7cd6\u9396\u3092\u963b\u5bb3\u5264\u3068\u3057\u3066\u7528\u3044\u308b\u7af6\u5408\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u7cd6\u9396\u30a2\u30ec\u30a4\u306e\u5b9f\u9a13\u3067\u306f\u3001\u3053\u308c\u3089\u6297\u4f53\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u7cd6\u9396\u306b\u5bfe\u3057\u3066\u975e\u5e38\u306b\u5f31\u3044\u7d50\u5408\u3057\u304b\u793a\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001LacNAc\u3068\u305d\u306e\u03b12-3Sia\u4fee\u98fe\u306b\u3064\u3044\u3066\u306f\u5f37\u304f\u7d50\u5408\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001BLN4\u3068BLN12\u306f\u3001NTD\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u307f\u3067\u306a\u304f\u3001N-\u578b\u7cd6\u9396\u3082\u305d\u306e\u7d50\u5408\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>SARS-CoV-2\u306b\u304a\u3044\u3066\u306f\u3001ACE2\u304c\u4e3b\u305f\u308b\u611f\u67d3\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001C\u578b\u30ec\u30af\u30c1\u30f3\uff08L-SIGN, DC-SIGN\u306a\u3069\uff09\u3082\u611f\u67d3\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u4ee3\u8868\u7684\u306a\u6297\u4f53\u304cSARS-CoV-2\u3068L-SIGN\u306e\u7d50\u5408\u3092\u963b\u5bb3\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306e\u5b9f\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002 \u963b\u5bb3\u52b9\u7387\u306f\u3001BLN14\u306e25\uff05\u304b\u3089BLN4\u306e50\uff05\u306b\u5206\u5e03\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u963b\u5bb3\u52b9\u679c\u306f\u3001\u6297\u4f53\u306eNTD\u306e\u7cd6\u9396\u306b\u5bfe\u3059\u308b\u76f4\u63a5\u7684\u306a\u7d50\u5408\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001L-SIGN\u3068\u306e\u7acb\u4f53\u969c\u5bb3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>ACE2\u306e\u767a\u73fe\u304c\u4f4e\u3044\u7d44\u7e54\u306e\u7d30\u80de\u306e\u5834\u5408\u306b\u3001L-SIGN\u3084DC-SIGN\u304cSARS-CoV-2\u306b\u5bfe\u3059\u308b\u7b2c\u4e8c\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u3068\u306a\u308b\u306e\u3067\u3042\u308c\u3070\u3001NTD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u6297\u4f53\u304cSARS-CoV-2\u306e\u611f\u67d3\u3092\u6291\u3048\u8fbc\u3080\u305f\u3081\u306b\u6709\u52b9\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3001\u7d50\u679c\u3068\u3057\u3066\u3001RBD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u6297\u4f53\u3068NTD\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3059\u308b\u30ab\u30af\u30c6\u30eb\u6297\u4f53\u304cSARS-CoV-2\u306e\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308b\u306f\u305a\u3001\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Israel Institute for Biological Research\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306eNTD\u306b\u5bfe\u3059\u308b12\u7a2e\u985e\u306e\u4e2d\u548c\u6297\u4f53\u306e\u7279\u6027\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%aentd%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%a8%e3%81%99%e3%82%8b%e4%b8%ad%e5%92%8c%e6%8a%97%e4%bd%93%e3%81%ae%e7%89%b9%e6%80%a7%e3%81%ab%e3%81%a4%e3%81%84\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-3565","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3565"}],"version-history":[{"count":14,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3565\/revisions"}],"predecessor-version":[{"id":4388,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3565\/revisions\/4388"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}