{"id":3536,"date":"2021-05-05T14:37:27","date_gmt":"2021-05-05T05:37:27","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3536"},"modified":"2021-05-05T18:20:48","modified_gmt":"2021-05-05T09:20:48","slug":"%e6%bd%b0%e7%98%8d%e6%80%a7%e5%a4%a7%e8%85%b8%e7%82%8e%e3%81%ae%e6%8a%97tnf%e6%8a%97%e4%bd%93%e6%b2%bb%e7%99%82%e5%8a%b9%e6%9e%9c%e3%82%92%e4%ba%88%e6%b8%ac%e3%81%99%e3%82%8b%e6%96%b0%e8%a6%8f","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%bd%b0%e7%98%8d%e6%80%a7%e5%a4%a7%e8%85%b8%e7%82%8e%e3%81%ae%e6%8a%97tnf%e6%8a%97%e4%bd%93%e6%b2%bb%e7%99%82%e5%8a%b9%e6%9e%9c%e3%82%92%e4%ba%88%e6%b8%ac%e3%81%99%e3%82%8b%e6%96%b0%e8%a6%8f\/","title":{"rendered":"\u6f70\u760d\u6027\u5927\u8178\u708e\u306e\u6297TNF\u6297\u4f53\u6cbb\u7642\u52b9\u679c\u3092\u4e88\u6e2c\u3059\u308b\u65b0\u898f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u3064\u3044\u3066\uff1aIgG\u306eJacalin\u7d50\u5408\u6027\u7cd6\u9396\u4fee\u98fe\u69cb\u9020\u306e\u5909\u5316"},"content":{"rendered":"<p>University of Pisa, Italy\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6f70\u760d\u6027\u5927\u8178\u708e\u306b\u304a\u3051\u308b\u65b0\u3057\u3044\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.654319\/full\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.654319\/full\/<\/a><\/p>\n<p>\u6f70\u760d\u6027\u5927\u8178\u708e\uff08Ulcerative colitis: UC\uff09\u306f\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308a\u3001\u5927\u8178\u4e0a\u76ae\u7d30\u80de\u306b\u708e\u75c7\u304c\u767a\u751f\u3057\u3001\u51fa\u8840\u3001\u4e0b\u75e2\u3001\u8179\u75db\u304c\u8d77\u3053\u308a\u307e\u3059\u3002 \u816b\u760d\u58ca\u6b7b\u56e0\u5b50\uff08Tumor necrosis factor: TNF\uff09\u306e\u767a\u73fe\u304c\u6f70\u760d\u6027\u5927\u8178\u708e\u3067\u306f\u4e0a\u6607\u3057\u3066\u304a\u308a\u3001 \u5927\u8178\u7c98\u819c\u306b\u708e\u75c7\u3092\u8d77\u3053\u3057\u3001\u5927\u8178\u4e0a\u76ae\u7d30\u80de\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u3053\u3068\u304b\u3089\u3001\u6297TNF\u6297\u4f53, infliximab (IFX) \u3084 adalimumab (ADA), \u304c\u6f70\u760d\u6027\u5927\u8178\u708e\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002.<\/p>\n<p>\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u6f70\u760d\u6027\u5927\u8178\u708e\u306e\u60a3\u8005\u306e30\uff05\u306f\u3001\u3053\u306e\u6297TNF\u6297\u4f53\u304c\u52b9\u304b\u306a\u3044\uff08non-responder\uff09\u3068\u3044\u3046\u3053\u3068\u3082\u3042\u308a\u3001\u6cbb\u7642\u52b9\u679c\u306b\u5bfe\u3057\u3066\u65e9\u671f\u306b\u4e88\u6e2c\u304c\u3067\u304d\u308b\u3053\u3068\u304c\u975e\u5e38\u306b\u91cd\u8981\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8457\u8005\u3089\u306e\u7814\u7a76\u306f\u3001\u6297TNF\u6297\u4f53\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u3092\u4e88\u6e2c\u3059\u308b\u4e0a\u3067\u3001IgG\u306eJacalin\uff08JAC\uff09\u7d50\u5408\u6027\u7cd6\u9396\u304c\u975e\u5e38\u306b\u826f\u3044\u30de\u30fc\u30ab\u30fc\u306b\u306a\u308b\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u4e0b\u56f3\u306b\u304a\u3044\u3066\u3001A\u306f\u6cbb\u7642\u524d\u306eJAC-IgG\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3092\u793a\u3057\uff08NHS = \u5065\u5e38\u8005, R = \u30ec\u30b9\u30dd\u30f3\u30c0\u30fc, NR = \u30ce\u30f3\u30ec\u30b9\u30dd\u30f3\u30c0\u30fc\uff09\u3001B\u306f\u6297TNF\u6297\u4f53\u6cbb\u7642\u5f8c\u306e\u305d\u308c\u3092\u793a\u3057\u307e\u3059\u3002<br \/>\nJacalin\u306f\u3001O\u578b\u7cd6\u9396\u3092\u8a8d\u8b58\u3059\u308b\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308a\u3001IgG\u306e\u3053\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u9055\u3044\u304c\u3069\u306e\u3088\u3046\u306b\u6297TNF\u6297\u4f53\u306e\u6cbb\u7642\u52b9\u679c\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u306e\u304b\uff1f\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u3067\u3059\u304c\u3001\u6cbb\u7642\u52b9\u679c\u306b\u5bfe\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u306f\u6210\u308a\u5f97\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u591a\u304f\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u306f\u3001IgG\u306e\u7cd6\u9396\u4fee\u98fe\u304c\u30a2\u30ac\u30e9\u30af\u30c8\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001Fc\u03b3RIIa\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u4ecb\u3057\u3066\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6d3b\u6027\u5316\u3084\u3001TNF\u03b1\u3001IL-6\u3089\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u3092\u4fc3\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30ea\u30e5\u30fc\u30de\u30c1\u3067\u306f\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u3084\u6297TNF\u6297\u4f53\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001IgG\u306e\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u304c\u5897\u52a0\u3059\u308b\u3068\u3044\u3046\u73fe\u8c61\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/UC_Biomarker_Jacalin-IgG.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/UC_Biomarker_Jacalin-IgG-300x101.png\" alt=\"\" width=\"300\" height=\"101\" class=\"alignleft size-medium wp-image-3543\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/UC_Biomarker_Jacalin-IgG-300x101.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/UC_Biomarker_Jacalin-IgG-600x202.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/UC_Biomarker_Jacalin-IgG.png 749w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Pisa, Italy\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6f70\u760d\u6027\u5927\u8178\u708e\u306b\u304a\u3051\u308b\u65b0\u3057\u3044\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.frontiersin.org\/articles\/10.3389<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e6%bd%b0%e7%98%8d%e6%80%a7%e5%a4%a7%e8%85%b8%e7%82%8e%e3%81%ae%e6%8a%97tnf%e6%8a%97%e4%bd%93%e6%b2%bb%e7%99%82%e5%8a%b9%e6%9e%9c%e3%82%92%e4%ba%88%e6%b8%ac%e3%81%99%e3%82%8b%e6%96%b0%e8%a6%8f\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-3536","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All 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