{"id":3508,"date":"2021-05-02T15:47:42","date_gmt":"2021-05-02T06:47:42","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3500"},"modified":"2021-06-28T07:04:19","modified_gmt":"2021-06-27T22:04:19","slug":"molecular-structures-at-the-binding-site-of-the-n501y-sars-cov-2-spike-protein-and-ace2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/molecular-structures-at-the-binding-site-of-the-n501y-sars-cov-2-spike-protein-and-ace2\/","title":{"rendered":"Molecular structures at the binding site of the SARS-CoV-2 spike protein of N501Y variant and ACE2\u00a0receptor"},"content":{"rendered":"<p>A group from University of British Columbia, etc. has reported studies on\u00a0 molecular structures at the binding site of the SARS-CoV-2 spike protein of N501Y variant and ACE2 receptor with using a cryo-electron microscopy.<br \/>\n<a href=\"https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.3001237\">https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.3001237<\/a><\/p>\n<p>The overall binding structure at the binding site of ACE2 and SARS-CoV-2 is almost identical to that of the unmutated version, with the exception of some local rearrangements. The aromatic ring of Y501 is sandwiched between Y41 and K353 of the ACE2 receptor, and\u00a0 Y501 in the SARS-CoV-2 spike protein and Y41 in the ACE2 receptor form a perpendicular y-shaped \u03c0\u2013\u03c0 stacking interaction. This could be a reason of the increased infectivity.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/Y501-mutationSARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-3501\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/Y501-mutationSARS-CoV-2-300x280.png\" alt=\"\" width=\"300\" height=\"280\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/Y501-mutationSARS-CoV-2-300x280.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/05\/Y501-mutationSARS-CoV-2.png 483w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>The same conclusion from other researchers as this was already blogged.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from University of British Columbia, etc. has reported studies on\u00a0 molecular structures at the binding<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/molecular-structures-at-the-binding-site-of-the-n501y-sars-cov-2-spike-protein-and-ace2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3508","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3508"}],"version-history":[{"count":12,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3508\/revisions"}],"predecessor-version":[{"id":4394,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3508\/revisions\/4394"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}