{"id":3476,"date":"2021-05-01T06:26:49","date_gmt":"2021-04-30T21:26:49","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3476"},"modified":"2021-07-21T23:14:48","modified_gmt":"2021-07-21T14:14:48","slug":"ace2%e3%81%aen90%e3%81%ae%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%81%afsars-cov-2%e3%81%a8%e3%81%ae%e7%b5%90%e5%90%88%e3%82%92%e5%bc%b1%e3%82%81%e3%80%81n322%e3%81%ae%e7%b3%96%e9%8e%96%e4%bf%ae","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/ace2%e3%81%aen90%e3%81%ae%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%81%afsars-cov-2%e3%81%a8%e3%81%ae%e7%b5%90%e5%90%88%e3%82%92%e5%bc%b1%e3%82%81%e3%80%81n322%e3%81%ae%e7%b3%96%e9%8e%96%e4%bf%ae\/","title":{"rendered":"ACE2\u306eN90\u306e\u7cd6\u9396\u4fee\u98fe\u306fSARS-CoV-2\u3068\u306e\u7d50\u5408\u3092\u5f31\u3081\u3001N322\u306e\u7cd6\u9396\u4fee\u98fe\u306f\u7d50\u5408\u3092\u5f37\u3081\u308b"},"content":{"rendered":"

Max Planck Institute of Biophysics\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001ACE2\u306e\u7cd6\u9396\u4fee\u98fe\u304cSARS-CoV-2\u306eRBD\u3068\u306e\u7d50\u5408\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u5206\u5b50\u52d5\u529b\u5b66\u3092\u7528\u3044\u3066\u30b7\u30e5\u30df\u30ec\u30fc\u30b7\u30e7\u30f3\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.pnas.org\/content\/118\/19\/e2100425118.long<\/a><\/p>\n

\u69cb\u9020\u7684\u306b\u898b\u3066\u3001ACE2\u306b\u3042\u308b\u56db\u3064\u306e\u7cd6\u9396\u4fee\u98fe\u4f4d\u7f6e\uff08N53, N90, N103, and N322\uff09\u304cSARS-CoV-2\u306eRBD\u3068\u7d50\u5408\u306b\u95a2\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u5185\u3001N90\u3068N322\u306e\u7cd6\u9396\u304c\u6700\u3082RBD\u3068\u306e\u7d50\u5408\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u7cd6\u9396\u306e\u69cb\u9020\u306e\u9055\u3044\u3082\u3082\u3061\u308d\u3093RBD\u3068\u306e\u7d50\u5408\u306b\u306f\u5f71\u97ff\u3057\u3001\u30a2\u30b7\u30a2\u30ed\u578b\u3068\u30cf\u30a4\u30de\u30f3\u30ce\u30fc\u30b9\u578b\u304c\u3088\u308a\u5f37\u304fRBD\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3088\u3046\u3067\u3059\u3002N90\u306b\u304a\u3044\u3066\u306f\u3001\u30de\u30f3\u30ce\u30fc\u30b9\u306e\u65b9\u304c\u30a2\u30b7\u30a2\u30ed\u3088\u308a\u3082\u3088\u308a\u5f37\u304f\u76f8\u4e92\u4f5c\u7528\u3057\u3001N322\u306b\u304a\u3044\u3066\u306f\u3001\u305d\u306e\u9006\u3067\u3042\u308a\u307e\u3059\u3002<\/p>\n

N90\u3068N322\u306e\u7cd6\u9396\u304cRBD\u3068\u306e\u7d50\u5408\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306f\u7570\u306a\u3063\u3066\u304a\u308a\u3001N90\u306e\u7cd6\u9396\u306fACE2\u3068RBD\u306e\u7d50\u5408\u3092\u963b\u5bb3\u3059\u308b\u65b9\u5411\u306b\u4f5c\u7528\u3057\u3001N322\u306e\u7cd6\u9396\u306f\u9006\u306bACE2\u3068RBD\u3068\u306e\u7d50\u5408\u3092\u5f37\u3081\u308b\u65b9\u5411\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002N322\u306e\u7cd6\u9396\u4fee\u98fe\u3092\u9664\u304f\u3088\u3046\u306a\u5909\u7570\u304cACE2\u306b\u767a\u751f\u3057\u305f\u5834\u5408\u306b\u306f\u3001ACE2\u3068RBD\u306e\u7d50\u5408\u306f\u975e\u5e38\u306b\u5f31\u304f\u306a\u308a\u307e\u3059\u3002N322\u306e\u7cd6\u9396\u306f\u4e3b\u306b\u3001RBD\u306eY369\u2013K378, R408, N437, N439, V503\u9818\u57df\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001V503\u306fN501Y\u5909\u7570\u306e\u8fd1\u508d\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u304b\u3089\u3001ACE2\u3068RBD\u306e\u7d50\u5408\u3092\u5f37\u3081\u3001\u611f\u67d3\u529b\u30a2\u30c3\u30d7\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u306a\u304a\u3001ACE2\u306e\u7cd6\u9396\u4fee\u98fe\u304cSARS-CoV-2\u306e\u7d50\u5408\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u5b9f\u9a13\u7684\u306b\u8abf\u3079\u305f\u8ad6\u6587\u306f\u5e7e\u3064\u304b\u5b58\u5728\u3057\u3001\u65e2\u306b\u4e0b\u8a18\u3092\u672c\u30d6\u30ed\u30b0\u3067\u3082\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002
\n\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u3068\u30cf\u30a4\u30de\u30f3\u30ce\u30fc\u30b9\u4fee\u98fe\u304cSARS-CoV-2\u306e\u7d50\u5408\u3092\u6291\u3048\u308b\u65b9\u5411\u306b\u50cd\u304f\u306e\u306f\u3001\u5b9f\u9a13\u7684\u306b\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u306d\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Max Planck Institute of Biophysics\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001ACE2\u306e\u7cd6\u9396\u4fee\u98fe\u304cSARS-CoV-2\u306eRBD\u3068\u306e\u7d50\u5408\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u5206\u5b50\u52d5\u529b\u5b66\u3092\u7528\u3044\u3066\u30b7\u30e5\u30df\u30ec\u30fc\u30b7\u30e7\u30f3\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/w<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-3476","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3476","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3476"}],"version-history":[{"count":7,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3476\/revisions"}],"predecessor-version":[{"id":4390,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3476\/revisions\/4390"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}