{"id":3443,"date":"2021-04-26T16:43:38","date_gmt":"2021-04-26T07:43:38","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3431"},"modified":"2021-04-27T16:44:49","modified_gmt":"2021-04-27T07:44:49","slug":"in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/","title":{"rendered":"In order to improve productivity of mAbs with CHO controlling those glycan structures\u00a0"},"content":{"rendered":"<p>A group from Daiichi Sankyo Co., Ltd. has reported about a new chemical which is added into CHO culture media and thereby is able to improve productivity of mAbs as therapeutic drugs.<br \/>\n<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0250416\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0250416<\/a><\/p>\n<p>Authors intended to improve productivity of mAbs with controlling those glycan modification by adding a chemical into CHO culture media.<br \/>\nThey started screening from 23,277 chemicals, and through the following 2nd screening condition; over 120% for relative mAb concentration, 105% for relative cell-specific productivity, and 80% for viability, a few candidates were selected. From the final selectins, 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide (MPPB) was selected as a most suitable chemical to meet the intended requirement. MPPB concentrations of 0.32 to 0.64 mM were used, and with this addition, the productivity of mAbs increased by 1.5times.<br \/>\nG0F was the major N-linked glycan, and G1F was decreased from 24.5 to 14.8% under the MPPB-added condition, although others were not changed<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/N-glycan-ratio_CHO.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/N-glycan-ratio_CHO-300x180.png\" alt=\"\" width=\"300\" height=\"180\" class=\"alignleft size-medium wp-image-3440\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/N-glycan-ratio_CHO-300x180.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/N-glycan-ratio_CHO-600x361.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/N-glycan-ratio_CHO.png 750w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Daiichi Sankyo Co., Ltd. has reported about a new chemical which is added into CHO culture media <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3443","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"A group from Daiichi Sankyo Co., Ltd. has reported abou\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"ja_JP\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09 - for the coming new age\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09\" \/>\n\t\t<meta property=\"og:description\" content=\"A group from Daiichi Sankyo Co., Ltd. has reported abou\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/10\/cropped-cropped-Mx-logo.png\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/10\/cropped-cropped-Mx-logo.png\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2021-04-26T07:43:38+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2021-04-27T07:44:49+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary\" \/>\n\t\t<meta name=\"twitter:title\" content=\"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09\" \/>\n\t\t<meta name=\"twitter:description\" content=\"A group from Daiichi Sankyo Co., Ltd. has reported abou\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/10\/cropped-cropped-Mx-logo.png\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#blogposting\",\"name\":\"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\\uff08(\\u540c)\\u30a8\\u30e0\\u30c3\\u30af, emukk LLC\\uff09\",\"headline\":\"In order to improve productivity of mAbs with CHO controlling those glycan structures\\u00a0\",\"author\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/author\\\/mx\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/wp-content\\\/uploads\\\/2021\\\/04\\\/N-glycan-ratio_CHO.png\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#articleImage\",\"width\":750,\"height\":451},\"datePublished\":\"2021-04-26T16:43:38+09:00\",\"dateModified\":\"2021-04-27T16:44:49+09:00\",\"inLanguage\":\"ja\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#webpage\"},\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#webpage\"},\"articleSection\":\"Technology, English, 2fea7d79-fb7d-4817-bb74-00cd61eb155b\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP#listItem\",\"position\":1,\"name\":\"\\u30db\\u30fc\\u30e0\",\"item\":\"https:\\\/\\\/www.emukk.com\\\/WP\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/category\\\/technology-en\\\/#listItem\",\"name\":\"Technology\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/category\\\/technology-en\\\/#listItem\",\"position\":2,\"name\":\"Technology\",\"item\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/category\\\/technology-en\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#listItem\",\"name\":\"In order to improve productivity of mAbs with CHO controlling those glycan structures\\u00a0\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP#listItem\",\"name\":\"\\u30db\\u30fc\\u30e0\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#listItem\",\"position\":3,\"name\":\"In order to improve productivity of mAbs with CHO controlling those glycan structures\\u00a0\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/category\\\/technology-en\\\/#listItem\",\"name\":\"Technology\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/#organization\",\"name\":\"\\u30a8\\u30e0\\u30c3\\u30af\",\"description\":\"for the coming new age\",\"url\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/wp-content\\\/uploads\\\/2020\\\/07\\\/Mx_512.png\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#organizationLogo\",\"width\":512,\"height\":512},\"image\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#organizationLogo\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/author\\\/mx\\\/#author\",\"url\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/author\\\/mx\\\/\",\"name\":\"Mx\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#authorImage\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/448196ac7ce48021a03dc87996f697247fa04352e0ce6309f336b34bb11ef44a?s=96&d=mm&r=g\",\"width\":96,\"height\":96,\"caption\":\"Mx\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#webpage\",\"url\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/\",\"name\":\"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\\uff08(\\u540c)\\u30a8\\u30e0\\u30c3\\u30af, emukk LLC\\uff09\",\"description\":\"A group from Daiichi Sankyo Co., Ltd. has reported abou\",\"inLanguage\":\"ja\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/en\\\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\\\/#breadcrumblist\"},\"author\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/author\\\/mx\\\/#author\"},\"creator\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/author\\\/mx\\\/#author\"},\"datePublished\":\"2021-04-26T16:43:38+09:00\",\"dateModified\":\"2021-04-27T16:44:49+09:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/#website\",\"url\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/\",\"name\":\"Mx (\\u30a8\\u30e0\\u30c3\\u30af, emukk)\",\"description\":\"for the coming new age\",\"inLanguage\":\"ja\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.emukk.com\\\/WP\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t<!-- All in One SEO -->\n\n","aioseo_head_json":{"title":"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09","description":"A group from Daiichi Sankyo Co., Ltd. has reported abou","canonical_url":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BlogPosting","@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#blogposting","name":"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09","headline":"In order to improve productivity of mAbs with CHO controlling those glycan structures\u00a0","author":{"@id":"https:\/\/www.emukk.com\/WP\/author\/mx\/#author"},"publisher":{"@id":"https:\/\/www.emukk.com\/WP\/#organization"},"image":{"@type":"ImageObject","url":"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/N-glycan-ratio_CHO.png","@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#articleImage","width":750,"height":451},"datePublished":"2021-04-26T16:43:38+09:00","dateModified":"2021-04-27T16:44:49+09:00","inLanguage":"ja","mainEntityOfPage":{"@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#webpage"},"isPartOf":{"@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#webpage"},"articleSection":"Technology, English, 2fea7d79-fb7d-4817-bb74-00cd61eb155b"},{"@type":"BreadcrumbList","@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/www.emukk.com\/WP#listItem","position":1,"name":"\u30db\u30fc\u30e0","item":"https:\/\/www.emukk.com\/WP","nextItem":{"@type":"ListItem","@id":"https:\/\/www.emukk.com\/WP\/en\/category\/technology-en\/#listItem","name":"Technology"}},{"@type":"ListItem","@id":"https:\/\/www.emukk.com\/WP\/en\/category\/technology-en\/#listItem","position":2,"name":"Technology","item":"https:\/\/www.emukk.com\/WP\/en\/category\/technology-en\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#listItem","name":"In order to improve productivity of mAbs with CHO controlling those glycan structures\u00a0"},"previousItem":{"@type":"ListItem","@id":"https:\/\/www.emukk.com\/WP#listItem","name":"\u30db\u30fc\u30e0"}},{"@type":"ListItem","@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#listItem","position":3,"name":"In order to improve productivity of mAbs with CHO controlling those glycan structures\u00a0","previousItem":{"@type":"ListItem","@id":"https:\/\/www.emukk.com\/WP\/en\/category\/technology-en\/#listItem","name":"Technology"}}]},{"@type":"Organization","@id":"https:\/\/www.emukk.com\/WP\/#organization","name":"\u30a8\u30e0\u30c3\u30af","description":"for the coming new age","url":"https:\/\/www.emukk.com\/WP\/","logo":{"@type":"ImageObject","url":"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/07\/Mx_512.png","@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#organizationLogo","width":512,"height":512},"image":{"@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#organizationLogo"}},{"@type":"Person","@id":"https:\/\/www.emukk.com\/WP\/author\/mx\/#author","url":"https:\/\/www.emukk.com\/WP\/author\/mx\/","name":"Mx","image":{"@type":"ImageObject","@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#authorImage","url":"https:\/\/secure.gravatar.com\/avatar\/448196ac7ce48021a03dc87996f697247fa04352e0ce6309f336b34bb11ef44a?s=96&d=mm&r=g","width":96,"height":96,"caption":"Mx"}},{"@type":"WebPage","@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#webpage","url":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/","name":"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09","description":"A group from Daiichi Sankyo Co., Ltd. has reported abou","inLanguage":"ja","isPartOf":{"@id":"https:\/\/www.emukk.com\/WP\/#website"},"breadcrumb":{"@id":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/#breadcrumblist"},"author":{"@id":"https:\/\/www.emukk.com\/WP\/author\/mx\/#author"},"creator":{"@id":"https:\/\/www.emukk.com\/WP\/author\/mx\/#author"},"datePublished":"2021-04-26T16:43:38+09:00","dateModified":"2021-04-27T16:44:49+09:00"},{"@type":"WebSite","@id":"https:\/\/www.emukk.com\/WP\/#website","url":"https:\/\/www.emukk.com\/WP\/","name":"Mx (\u30a8\u30e0\u30c3\u30af, emukk)","description":"for the coming new age","inLanguage":"ja","publisher":{"@id":"https:\/\/www.emukk.com\/WP\/#organization"}}]},"og:locale":"ja_JP","og:site_name":"Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09 - for the coming new age","og:type":"article","og:title":"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09","og:description":"A group from Daiichi Sankyo Co., Ltd. has reported abou","og:url":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/","og:image":"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/10\/cropped-cropped-Mx-logo.png","og:image:secure_url":"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/10\/cropped-cropped-Mx-logo.png","article:published_time":"2021-04-26T07:43:38+00:00","article:modified_time":"2021-04-27T07:44:49+00:00","twitter:card":"summary","twitter:title":"In order to improve productivity of mAbs with CHO controlling those glycan structures - Mx\uff08(\u540c)\u30a8\u30e0\u30c3\u30af, emukk LLC\uff09","twitter:description":"A group from Daiichi Sankyo Co., Ltd. has reported abou","twitter:image":"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/10\/cropped-cropped-Mx-logo.png"},"aioseo_meta_data":{"post_id":"3443","title":null,"description":null,"keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":null,"schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"breadcrumb_settings":null,"limit_modified_date":false,"ai":null,"created":"2021-06-27 07:43:01","updated":"2025-06-07 01:18:42","seo_analyzer_scan_date":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.emukk.com\/WP\" title=\"\u30db\u30fc\u30e0\">\u30db\u30fc\u30e0<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.emukk.com\/WP\/en\/category\/technology-en\/\" title=\"Technology\">Technology<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tIn order to improve productivity of mAbs with CHO controlling those glycan structures \n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"\u30db\u30fc\u30e0","link":"https:\/\/www.emukk.com\/WP"},{"label":"Technology","link":"https:\/\/www.emukk.com\/WP\/en\/category\/technology-en\/"},{"label":"In order to improve productivity of mAbs with CHO controlling those glycan structures\u00a0","link":"https:\/\/www.emukk.com\/WP\/en\/in-order-to-improve-productivity-of-mabs-with-cho-controlling-those-glycan-structures\/"}],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3443"}],"version-history":[{"count":5,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3443\/revisions"}],"predecessor-version":[{"id":3454,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3443\/revisions\/3454"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}