{"id":3418,"date":"2021-04-25T19:11:29","date_gmt":"2021-04-25T10:11:29","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3418"},"modified":"2021-07-21T23:15:29","modified_gmt":"2021-07-21T14:15:29","slug":"%e9%96%a2%e7%af%80%e3%83%aa%e3%83%a5%e3%83%bc%e3%83%9e%e3%83%81%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%bb%91%e8%86%9c%e7%b7%9a%e7%b6%ad%e8%8a%bd%e7%b4%b0%e8%83%9e%e3%81%ae%ce%b12-6%e3%82%b7%e3%82%a2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e9%96%a2%e7%af%80%e3%83%aa%e3%83%a5%e3%83%bc%e3%83%9e%e3%83%81%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%bb%91%e8%86%9c%e7%b7%9a%e7%b6%ad%e8%8a%bd%e7%b4%b0%e8%83%9e%e3%81%ae%ce%b12-6%e3%82%b7%e3%82%a2\/","title":{"rendered":"\u95a2\u7bc0\u30ea\u30e5\u30fc\u30de\u30c1\u306b\u304a\u3051\u308b\u6ed1\u819c\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u03b12-6\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u306e\u5909\u5316\u3068\u95a2\u7bc0\u306e\u708e\u75c7\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>University of Glasgow, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u95a2\u7bc0\u30ea\u30e5\u30fc\u30de\u30c1\u306b\u304a\u3051\u308b\u6ed1\u819c\u7dda\u7dad\u82bd\u7d30\u80de\uff08Synovial fibroblasts\uff1aSFs\uff09\u306e\u03b12-6\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u306e\u5909\u5316\u3068\u95a2\u7bc0\u306e\u708e\u75c7\u306b\u3064\u3044\u3066\u3001\u8e0f\u307f\u8fbc\u3093\u3060\u7814\u7a76\u3092\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-22365-z\">https:\/\/www.nature.com\/articles\/s41467-021-22365-z<\/a><\/p>\n<p>\u95a2\u7bc0\u30ea\u30e5\u30fc\u30de\u30c1\u3092\u767a\u75c7\u3059\u308b\u3068\u3001IgG\u306e\u7cd6\u9396\u4fee\u98fe\u304c\u30a2\u30ac\u30e9\u30af\u30c8\u578b\u306b\u5909\u5316\u3059\u308b\u3001TNF\u03b1\u304c\u5897\u52a0\u3059\u308b\u3068\u3044\u3046\u3088\u3046\u306a\u4e8b\u8c61\u306f\u826f\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u8457\u8005\u3089\u306f\u3001\u6ed1\u819c\u7e4a\u7dad\u82bd\u7d30\u80de\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u5909\u5316\u3092\u30ec\u30af\u30c1\u30f3\u3068MS\u3092\u7528\u3044\u3066\u8a73\u7d30\u306b\u8a55\u4fa1\u3057\u3066\u304a\u308a\u3001N\u578b\u7cd6\u9396\u3001O\u578b\u7cd6\u9396\u3068\u3082\u306b\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30b7\u30a2\u30eb\u9178\u306e\u6e1b\u5c11\u306f\u3001\u03b12-3Sia\u3067\u306f\u306a\u304f\u3001\u03b12-6Sia\u3067\u9855\u8457\u306b\u767a\u751f\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u66f4\u306b\u3001\u03b12-6Sia\u306e\u6e1b\u5c11\u306e\u5ea6\u5408\u3044\u306f\u3001\u75c5\u614b\u306e\u9032\u884c\u5ea6\u3068\u3082\u76f8\u95a2\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u03b12-6Sia\u306e\u6e1b\u5c11\u306f\u3001TNF\u03b1\u306b\u3088\u3063\u3066\u76f4\u63a5\u7684\u306b\u8a98\u8d77\u3055\u308c\u3066\u304a\u308a\u3001\u4ed6\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-1, IL-17\u3089\uff09\u306f\u95a2\u4e0e\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u8208\u5473\u6df1\u3044\u306e\u306f\u3001\u03b12-6Sia\u306e\u6e1b\u5c11\u304c\u6ed1\u819c\u7e4a\u7dad\u82bd\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u4e3b\u4f53\u7684\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u304b\uff1f\u9032\u884c\u3059\u308b\u708e\u75c7\u306e\u9593\u63a5\u7684\u306a\u7d50\u679c\u306a\u306e\u304b\uff1f\u3068\u3044\u3046\u7591\u554f\u3067\u3042\u308a\u307e\u3059\u3002\u8457\u8005\u3089\u306f\u3001\u03b1-6Sia\u3092siRNA\u3092\u7528\u3044\u3066\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3055\u305b\u308b\u3068\u3001IL-6\u3084CcL2\u306e\u7523\u751f\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u6cbb\u7642\u65b9\u91dd\u306b\u3082\u95a2\u308f\u308b\u3068\u3066\u3082\u610f\u7fa9\u6df1\u3044\u3053\u3068\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u4e0b\u56f3\u306b\u304a\u3044\u3066\u3001CIA\u3068\u306f\u3001Collagen-induced arthritis\u306e\u3053\u3068\u3002<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Collagen-induced-arthritis.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Collagen-induced-arthritis-300x112.png\" alt=\"\" width=\"300\" height=\"112\" class=\"alignleft size-medium wp-image-3420\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Collagen-induced-arthritis-300x112.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Collagen-induced-arthritis-600x225.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Collagen-induced-arthritis-768x288.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Collagen-induced-arthritis.png 892w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Glasgow, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u95a2\u7bc0\u30ea\u30e5\u30fc\u30de\u30c1\u306b\u304a\u3051\u308b\u6ed1\u819c\u7dda\u7dad\u82bd\u7d30\u80de\uff08Synovial fibroblasts\uff1aSFs\uff09\u306e\u03b12-6\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u306e\u5909\u5316\u3068\u95a2\u7bc0\u306e\u708e\u75c7\u306b\u3064\u3044\u3066\u3001\u8e0f\u307f\u8fbc\u3093\u3060\u7814\u7a76\u3092<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e9%96%a2%e7%af%80%e3%83%aa%e3%83%a5%e3%83%bc%e3%83%9e%e3%83%81%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%bb%91%e8%86%9c%e7%b7%9a%e7%b6%ad%e8%8a%bd%e7%b4%b0%e8%83%9e%e3%81%ae%ce%b12-6%e3%82%b7%e3%82%a2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-3418","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"University of Glasgow, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u95a2\u7bc0\u30ea\u30e5\u30fc\u30de\u30c1\u306b\u304a\u3051\u308b\u6ed1\u819c\u7dda\u7dad\u82bd\u7d30\u80de\uff08Syn\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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