{"id":3347,"date":"2021-04-21T14:35:11","date_gmt":"2021-04-21T05:35:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3341"},"modified":"2021-04-21T19:08:16","modified_gmt":"2021-04-21T10:08:16","slug":"maackia-amurensis-lectin-reduces-the-expression-levels-of-ace2-adam17-furin-etc","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/maackia-amurensis-lectin-reduces-the-expression-levels-of-ace2-adam17-furin-etc\/","title":{"rendered":"Maackia amurensis lectin reduces the expression levels of ACE2, ADAM17, Furin, etc.\u00a0: A new finding in suppressing SARS-CoV-2 infection"},"content":{"rendered":"<p>A group from Rowan University, Stratford, USA, etc. has suggested that Maackia amurensis lectin (MAL, MAA, MASL as abbreviated names) could be effctive in inhibiting SARS-CoV-2 infection.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8019238\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8019238\/<\/a><\/p>\n<p>Oral squamous cells were used as a model cell in this study. Transcriptome analysis was done to investigate effects of MAL onto ACE2, ADAM17, Furin, and Glycosyltransferases (GalNAc-T, ST6GalNAc-1, and ST6GalNAc-2\uff09.<br \/>\nInterestingly, it was shown that those decreased in a MAL dose dependent manner. For instance, at a dose of 1925nM of MAL, ACE2 mRNA level decreased by 60\uff05, ADAM17 by 40\uff05, and ST6GalNAc-1 by 60%. As a result of these events, MAL decreases inflammatory signaling events that would otherwise lead to activation of the IL6 amplifier implicated in COVID-19 induced ARDS<\/p>\n<p>MAL is known to have binding specificity to \u03b12-3Sia.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL-300x102.png\" alt=\"\" width=\"300\" height=\"102\" class=\"alignleft size-medium wp-image-3342\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL-300x102.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL-600x204.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL.png 623w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Rowan University, Stratford, USA, etc. has suggested that Maackia amurensis lectin (MAL, MAA, MAS<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/maackia-amurensis-lectin-reduces-the-expression-levels-of-ace2-adam17-furin-etc\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3347","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3347"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3347\/revisions"}],"predecessor-version":[{"id":3349,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3347\/revisions\/3349"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}